Abstract
Escherichia coli was found attached to and envacuolated within colonic columnar epithelial cells from 24 to 144 hr after monocontamination of neonatal pigs. Cellular changes were minimal until edema of the lamina propria developed 144 hr after monocontamination. Intracellular lipid was increased after bacterial penetration, but lipid was also present in the colonic epithelium of neonatal germfree pigs. Cellular degeneration did not appear to result directly from bacterial invasion of the cell, but rather, from subsequent edema of the subepithelial lamina and impaired circulation, perhaps as the result of intravascular endotoxin.
The experimental condition described may provide a basis for elucidating the pathogenesis of ulcerative colitis and/or regional enteritis of the colon.
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Supported in part by US Public Health Service Research Grant AI-06461 from the National Institute of Allergy and Infectious Diseases, and General Medical Research Grant FR-05567.
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Staley, T.E., Corley, L.D. & Jones, E.W. Early pathogenesis of colitis in neonatal pigs monocontaminated withEscherichia coli . Digest Dis Sci 15, 923–935 (1970). https://doi.org/10.1007/BF02236060
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DOI: https://doi.org/10.1007/BF02236060