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Effect of vagotomy and pyloroplasty on pancreatic dose-response curves to secretin in man

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Abstract

Pancreatic dose-response curves to secretin were obtained in 6 patients with duodenal ulcer before and after vagotomy and pyloroplasty. Pancreatic secretion was determined by a stepwise increase in secretin infused intravenously in progressively increasing doses, ranging from 0.1 to 3.6 units/kg/hr. Vagotomy and pyloroplasty did not cause significant changes in pancreatic dose-response curves for the volume flow and bicarbonate output, suggesting that the integrity of vagal nerves is of no major importance in the response of the pancreas to exogenous secretin.

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Authors and Affiliations

  1. From the Institute of Physiology, and the III Surgical Clinic, Medical Academy, Krakow, Poland

    S. J. Konturek MD, T. Popiela MD & P. Thor MD

Authors
  1. S. J. Konturek MD
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  2. T. Popiela MD
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  3. P. Thor MD
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Konturek, S.J., Popiela, T. & Thor, P. Effect of vagotomy and pyloroplasty on pancreatic dose-response curves to secretin in man. Digest Dis Sci 16, 1087–1090 (1971). https://doi.org/10.1007/BF02235165

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  • DOI: https://doi.org/10.1007/BF02235165

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