Abstract
Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the ql5–q2l region of human chromosom e15 and to the E5-G region of murine chromosome 2. These localizations strengthen a syntenic group conserved between human chromosome 15 and mouse chromosome 2. The localization of the HDC gene on the human chromosome 15 map shows that it is not included within the Prader-Willi Syndrome region (PWCR).
Similar content being viewed by others
References
Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J (1992) Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum Genet 90:235–238
Donlon TA, Malcolm S (1991) Report of the committee on the genetic constitution of chromosome 15. Human gene mapping. Cytogenet Cell Genet 58:624–642
Ericson H, Watanabe T, Köhler C (1987) Morphological analysis of the tuberomammillary nucleus in the rat brain: delineation of subgroups with antibody against L-histidine decarboxylase as a marker. J Comp Neurol 263:1–24
Joseph DR, Sullivan PM, Wang YM, Kozak C, Fenstermacher DA, Behrendsen ME, Zahnow CA (1990) Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. Proc Natl Acad Sci USA 87:733–737
Leff SE, Brannan CI, Reed ML, Özçelik T, Francke U, Copeland NG, Jenkins NA (1992) Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi Syndrome region. Nature Genet 2: 259–264
Malcolm S, Donlon TA (1994) Report of the second international workshop on human chromosome 15 mapping, 1994. Cytogenet Cell Genet 67: 1–14
Martin SAM, Bulfield G (1984) A structural gene (Hdc-s) for mouse kidney histidine decarboxylase. Biochem Genet 22:645–656
Mattei MG, Philip N, Passage E, Mandel JL, Mattei JF (1985) DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet 69:268–271
McGeer PL, Eccles JC, McGeer EG (1987) Molecular neurobiology of the mammalian brain, 2nd edn. Plenum Press, New York
Schwartz JC, Garbarg M, Pollard H (1986) Histaminergic transmission in the brain. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Handbook of physiology. The nervous system IV. American Physiological Society, Bethesda, Maryland, pp 257–316
Siracusa LD, Abbott CM (1992) Mouse chromosome 2. Sixth international mouse genome mapping workshop. Mamm Genome (suppl) 3: S20-S43
Steinbusch HWM (1991) Distribution of histaminergic neurons and fibers in rat brain. Acta Otolaryngol Suppl (Stockh) 479: 12–23
Touraine P, Mbikay M, Seidah NG, Chretien M (1990) Le syndrome de Prader-Willi-Labhart: relations avec l'hypothalamus et le chromosome 15. Ann Endocrinol (Paris) 51:202–208
Wada J, Inagaki N, Yamatodani A, Watanabe T (1991) Is the histaminergic neuron system a regulatory center for whole-brain activity? Trends Neurosci 14:415–417
Yatsunami K, Ohtsu H, Tsuchikawa M, Higuchi T, Ishibashi K, Shida A, Shima Y, Nakagawa S, Yamauchi K, Yamamoto M, Hayashi N, Watanabe T, Ichikawa A (1994) Structure of the Lhistidine decarboxylase gene. J Biol Chem 269:1554–1559
Zahnow CA, Yi HF, McBride W, Joseph DR (1991) Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. DNA Seq 1: 395–400
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Malzac, P., Mattei, MG., Thibault, J. et al. Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region. Hum Genet 97, 359–361 (1996). https://doi.org/10.1007/BF02185772
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02185772