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The role of glycine in the biosynthesis of a terpene

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  • Chimica, Biochimica, Biophysica
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Zusammenfassung

Mit doppelt markiertem Glycin konnte gezeigt werden, dass das Kohlenstoffatom der Methylgruppe viel besser als das Kohlenstoffatom der Karboxylgruppe in die Isoprengruppe des Ophiobolins B ausCochiobolus miyabeanus eingebaut wird. Die Radioaktivität wird in Ophiobolin B eingebaut, wenn die folgenden Verbindungen verwendet werden: [3-14C]-Serin, [14C-Methyl]-Sarcosin, [14C-Methyl]-Methionin, und [14C] Formate.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, 07030, Hoboken, New Jersey, USA

    A. K. Bose, K. S. Khanchandani & B. L. Hungund

Authors
  1. A. K. Bose
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  2. K. S. Khanchandani
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  3. B. L. Hungund
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Additional information

a)Studies on Biosynthesis. Part V. for Part IV, seeM. Anchel, A. K. Bose, K. S. Khanchandani andP. T. Funke, Phytochem.9, 2135 (1970). b) Presented in part at the 3rd Natural Products Symposium, University of West Indies, Jamaica, January 1970.

The support of this research by Stevens Institute of Technology is gratefully acknowledged. We wish to thank Dr.J. H. Davis and Prof.L. Z. Pollara for their interest and encouragement and Drs.H. Levy, P. T. Funke, M. S. Manhas, P. K. Bhattacharyya andM. Anchel for valuable discussions and help with some of the experiments. We are particularly thankful to Dr.L. Canonica for providing us with cultures ofCochiobolus miyabeanus that made our work on ophiobolin B possible.

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Bose, A.K., Khanchandani, K.S. & Hungund, B.L. The role of glycine in the biosynthesis of a terpene. Experientia 27, 1403–1404 (1971). https://doi.org/10.1007/BF02154255

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