Abstract
The uptake-index method was used to study the transport of amino acids through the blood-retinal and blood-brain barriers in rats. The results indicate the existence of at least two different, similar carriers in both barriers, i.e., one each for neutral and basic amino acids. A third separate transport system for taurine was found in the blood-retinal barrier. All of the carrier systems studied transported amino acids from blood to nervous tissue.
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Aim A, Törnquist P (1981) The uptake index method applied to studies on the blood-retinal barrier. I. A methodological study. Acta Physiol Scand 113: 73–79
Alm A, Törnquist P, Mäepea O (1981) The uptake index method applied to studies on the blood-retinal barrier. II. Transport of several hexoses by a common carrier. Acta Physiol Scand 113: 81–84
Awapara J, Landua AJ, Fuerst R (1950) Distribution of free amino acids and related substances in organs of rat. Biochim Biophys Acta 5: 457–462
Berson EL, Hayes KC, Rabin AR, Schmidt SY, Watson G (1976) Retinal degeneration in cats fed casein. II. Supplementation with methionine, cysteine, or taurine. Invest Ophthalmol Vis Sci 15: 52–58
Christensen HN (1975) In: Biological transport. W. A. Benjamin, Reading, Massachusetts, pp 18–19 and 90–92
Crocket ME, Daniel PM, Pratt OE (1978) A comparison of the transport systems which carryl-methionine across the blood-retinal and blood-brain barriers. J Physiol (Lond) 280: 39P
Grayson MC, Laties AM (1971) Ocular localization of sodium florescein: Effects of administration in rabbit and monkey. Arch Ophthalmol 85: 600–609
Jacobsen JG, Smith Jr LH (1968) Biochemistry and physiology of taurine and taurine derivates. Physiol Rev 48: 424–511
Miller S, Steinberg RH (1976) Transport of taurine,l-methionine and 3-O-methyl-D-glucose across the frog retinal pigment epithelium. Exp Eye Res 23: 177–189
Oja SS, Kontro P (1978) Neurotransmitter actions of taurine in the central nervous system. In: Barbeau A, Huxtable RJ (eds) Taurine and neurological disorders. Raven Press, New York, pp 181–200
Oldendorf WH (1970) Measurement of brain uptake of radiolabeled substances using tritiated water as internal standard. Brain Res 24: 372–376
Oldendorf WH, Szabo J (1976) Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol 230: 94–98
Pardridge WM, Oldendorf WH (1977) Transport of metabolic substrates through the blood-brain barrier. J Neurochem 28: 5–12
Pasantes-Morales H, Klethi J, Ledig M, Mandel P (1972a) Free amino acids in chicken and rat retina. Brain Res 41: 494–497
Pasantes-Morales H, Klethi J, Urban PF, Mandel P (1972b) The physiological role of taurine in retina: Uptake and effect on electroretinogram (ERG). Physiol Chem Phys 4: 339–348
Pasantes-Morales H, Urban PF, Klethi J, Mandel P (1973) Light stimulated release of taurine from chicken retina. Brain Res 51: 375–378
Reddy VN, Chakrapani B, Lim CP (1977) Blood-vitrous barrier to amino acids. Exp Eye Res 25: 543–554
Schmidt SY, Berson EL, Hayes KC (1976) Retinal degeneration in cats fed casein. I. Taurine deficiency. Invest Ophthalmol Vis Sci 15: 47–52
Tornquist P (1979) Capillary permeability in the cat choroid, studies with the single injection technique (II). Acta Physiol Scand 106: 425–430
Törnquist P, Aim A (1982) Amino acid transport through the blood-retinal barrier. Invest Ophthalmol Vis Sci (suppl) 22: 179
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Presented at the 1984 meeting of the Club Jules Gonin in Lausanne, Switzerland
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Törnquist, P., Alm, A. Carrier-mediated transport of amino acids through the blood-retinal and the blood-brain barriers. Graefe's Arch Clin Exp Ophthalmol 224, 21–25 (1986). https://doi.org/10.1007/BF02144127
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DOI: https://doi.org/10.1007/BF02144127