Skip to main content
SpringerLink
Log in

Characteristics of the inflammatory process in murine lymphocytic choriomeningitis

  • Published:
Medical Microbiology and Immunology Aims and scope Submit manuscript

Conclusions

At this stage, the only cell population that is directly implicated in the induction of fatal lymphocytic choriomeningitis is the class I MHC-restricted immune T cell. However, it is not clear that cell-mediated lysis is central to the development of neurological symptoms or that the T cells act alone to cause immunopathology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allan JE, Doherty PC (1985) Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. Cell Immunol 90:401–407

    Article  PubMed  Google Scholar 

  2. Allan JE, Doherty PC (1985) Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis. Immunogenetics 21:581–590

    Article  PubMed  Google Scholar 

  3. Allan JE, Doherty PC (1985) Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replicationin vivo. Scand J Immunol 22:367–379

    PubMed  Google Scholar 

  4. Austyn JM, Gordon S (1981) F4/80: a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 11:805–815

    PubMed  Google Scholar 

  5. Bowern NA, Ramshaw IA, Clark IA, Doherty PC (1984) Inhibition of autoimmune neuropathological process by treatment with an iron chelating agent. J Exp Med 160:1532–1543

    Article  PubMed  Google Scholar 

  6. Doherty PC (1986) Virus-immune T cells and the major histocompatibility complex: evolution of some basic concepts over the past two years. Experientia (in press)

  7. Doherty PC, Allen JE (1985) Participation of cyclophosphamide-resistant T cells in murine lymphocytic choriomeningitis. Scand J Immunol 21:127–132

    PubMed  Google Scholar 

  8. Halliwell B (1982) Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease? Cell Biol Int Rep 6:529–542

    Article  PubMed  Google Scholar 

  9. Pfau CJ, Saron MF, Pevear DC (1985) Lack of correlation between cytotoxic T lymphocytes and lethal murine lymphocytic choriomeningitis. J Immunol 13:597–602

    Google Scholar 

  10. Thomsen AR, Bro-JØrgensen K, Volkert M (1983) Fatal meningitis following lymphocytic choriomeningitis virus infection reflects delayed-type hypersensitivity rather than cytotoxicity. Scand J Immunol 17:139–145

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Pathology, The John Curtin School of Medical Research, 2601, Canberra, ACT, Australia

    P. C. Doherty, N. A. Bowern, J. E. Dixon & J. E. Allan

Authors
  1. P. C. Doherty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Bowern
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Dixon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. E. Allan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Doherty, P.C., Bowern, N.A., Dixon, J.E. et al. Characteristics of the inflammatory process in murine lymphocytic choriomeningitis. Med Microbiol Immunol 175, 193–195 (1986). https://doi.org/10.1007/BF02122449

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02122449

Keywords

Search

Navigation