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On the action of sulfanilamide

XIV. Growth of a para-aminobenzoic acid requiringE. coli without para-aminobenzoic acid

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Summary

Methionine, xanthine and thymine replace para-aminobenzoic acid as a growth factor for the para-aminobenzoic-lessE.coli mutant strain 273.

The same substances were able to antagonize non competitively the bacteriostatical activity of 2000 mg/l sulfanilamide completely. It was further shown that the observed differences in sensitivity of the reaction chains leading to methionine, xanthine and thymine are not due to a difference in sensitivity to sulfanilamide but a difference in sensitivity to para-aminobenzoic acid. This seems to indicate that there exists only one reaction which is inhibited by sulfanilamide.

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Authors and Affiliations

  1. Laboratory of Hygiene of the University, Utrecht

    P. G. de Haan & K. C. Winkler

Authors
  1. P. G. de Haan
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  2. K. C. Winkler
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XIII: Antonie van Leeuwenhoek15, 136, 1949.

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de Haan, P.G., Winkler, K.C. On the action of sulfanilamide. Antonie van Leeuwenhoek 17, 107–118 (1951). https://doi.org/10.1007/BF02062254

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  • DOI: https://doi.org/10.1007/BF02062254

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