Skip to main content
SpringerLink
Log in

On the67Ga-binding acid mucopolysaccharide in malignant tumor

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The present study was undertaken to determine the structure of67Ga-binding acid mucopolysaccharide in tumor tissues. It was determined from measuring neutral saccharide in the structure that the principal67Ga-binding acid mucopolysaccharide in the tumor was keratan sulfate and/or keratan polysulfate. On the other hand, it was clarified from the results of mucopolysaccharase treatment that the main67Ga-binding acid mucopolysaccharide in tumor was not keratan sulfate, heparan sulfate, heparin, nor chondroitin sulfate A, B, or C. Based on the present results, it was deduced that the main67Ga-binding acid mucopolysaccharide in tumor is keratan polysulfate and that this acid mucopolysaccharide plays the most important role in tumor accumuation of67Ga.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. L. EDWARDS, R. L. HAYES, J. Nucl. Med., 10 (1969) 103.

    PubMed  Google Scholar 

  2. A. ANDO, Studies on the Tumor Affinity of169Yb,167Tm,67Ga and111In, PhD Thesis, Kyushu University (in Japanese), 1979, p. 82.

  3. A. ANDO, I. ANDO, T. HIRAKI, M. TAKESHITA, S. TANABE, R. YAMAZAKI, K. HISADA, Radioisotopes, 29 (1980) 250.

    PubMed  Google Scholar 

  4. A. ANDO, I. ANDO, T. HIRAKI, M. TAKESHITA, K. HISADA, Proc. 3rd World Congress of Nuclear Medicine and Biology II, Paris, France, 1982, p. 1772.

    Google Scholar 

  5. A. ANDO, I. ANDO, T. HIRAKI, M. TAKESHITA, K. HISADA, Int. J. Nucl. Med. Biol., 10 (1983) 1.

    PubMed  Google Scholar 

  6. A. ANDO, I. ANDO, T. HIRAKI, M. TAKESHITA, K. HISADA, Eur. J. Nucl. Med., 7 (1982) 298.

    PubMed  Google Scholar 

  7. A. ANDO, I. ANDO, K. SAKAMOTO, T. HIRAKI, K. HISADA, M. TAKESHITA, Eur. J. Nucl. Med., 8 (1983) 440.

    PubMed  Google Scholar 

  8. S. KOJIMA, Y. HAMA, K. MIYASHITA, A. KUBODERA, Jpn. J. Nucl. Med., 19 (1982) 67.

    Google Scholar 

  9. T. SASAKI, S. KOJIMA, A. KUBODERA, Eur. J. Nucl. Med., 7 (1982) 545.

    PubMed  Google Scholar 

  10. S. KOJIMA, Y. HAMA, T. SASAKI, A. KUBODERA, Eur. J. Nucl. Med., 8 (1983) 52.

    PubMed  Google Scholar 

  11. Y. HAMA, T. SASAKI, S. KOJIMA, A. KUBODERA, Eur. J. Nucl. Med., 9 (1984) 51.

    PubMed  Google Scholar 

  12. A. ANDO, I. ANDO, T. HIRAKI, K. HISADA, K. NITTA, H. OGAWA, Eur. J. Nucl. Med., 9 (1984) 300.

    PubMed  Google Scholar 

  13. A. ANDO, I. ANDO, Abstracts of 7th Japanese Carbohydrate Symposium, Osaka, Japan, 1984, p. 96.

  14. O. H. LOWRY, N. J. ROSEBROUGH, A. L. FARR, R. J. RANDALL, J. Biol. Chem., 193 (1951) 265.

    PubMed  Google Scholar 

  15. A. H. BROWN, Arch. Biochem., 11 (1946) 269.

    Google Scholar 

  16. D. AMINOFF, Biochem. J., 81 (1961) 384.

    PubMed  Google Scholar 

  17. W. E. TREVELYAM, J. S. HARRISON, Biochem. J., 50 (1952) 298.

    PubMed  Google Scholar 

  18. A. SCHILLER, G. A. SLOVER, A. DORFMAN, J. Biol. Chem., 236 (1961) 983.

    PubMed  Google Scholar 

  19. M. B. MATHEWS, J. A. CIFONELLI, J. Biol. Chem., 240 (1965) 4140.

    PubMed  Google Scholar 

  20. A. ANDO, H. HISADA, T. HIRAKI, I. ANDO, S. SANADA, Radioisotopes, 23 (1974) 161.

    Google Scholar 

  21. A. ANDO, K. DOISHITA, I. ANDO, S. SANADA, T. HIRAKI, M. MIDSUKAMI, K. HISADA, Radioisotopes, 26 (1977) 421.

    PubMed  Google Scholar 

  22. L. ALPERT, R. FRIEDMAN, Clin. Nucl. Med., 6 (1981) 378.

    PubMed  Google Scholar 

  23. L. J. ANGHILERI, M. HEIDBREDER, Oncology, 34 (1977) 74.

    PubMed  Google Scholar 

  24. A. ANDO, K. HISADA, T. HIRAKI, I. ANDO, S. SANADA, Radioisotopes, 23 (1974) 52.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Allied Medical Professions, Kanazawa University, 5-11-80, Kodatsuno, 920, Kanazawa City, Japan

    A. Ando & I. Ando

Authors
  1. A. Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Ando
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ando, A., Ando, I. On the67Ga-binding acid mucopolysaccharide in malignant tumor. Journal of Radioanalytical and Nuclear Chemistry, Articles 99, 97–107 (1986). https://doi.org/10.1007/BF02060830

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02060830

Keywords

Search

Navigation