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Mitochondrial encephalomyopathy — two years follow-up by MRI

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Abstract

A case of mitochondrial encephalomyopathy (MEM) followed-up by MRI for 2 1/2y is presented. MRI showed gross, diffusely distributed white matter lesions in both hemispheres predominantly in frontal, parietal, temporal and occipital locations a marked ventriculomegaly indicative of cerebral atrophy. Except a slight increase of the cerebral atrophy there were no changes in the follow-up examinations. There are no specific MRI findings in MEM, the diagnosis is established by the synopsis of MRI, laboratory data and muscle biopsy.

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References

  1. Valk J, van der Knapp MS (1989) Magnetic Resonance of Myelin, Myelination and Myelin Disorders Springer, Berlin Heidelberg New York

    Google Scholar 

  2. Sengers RCA, Stadhouders AM, Trijbels JMF (1984) Mitochondrial myopathies. Eur J Pediatr 141: 192

    PubMed  Google Scholar 

  3. Di Mauro S, Bonilla E, Zeviani M, Nakagawa M, De Vivo DC (1985) Mitochondrial myopathies. Ann Neurol 17: 521

    Article  PubMed  Google Scholar 

  4. Morgan-Hughes JA, Hayes DJ, Clark JB, Landdon DN, Swash M, Stark RJ, Rudge P (1982) Mitochondrial Encephalomyopathies, biochemical studies in two cases revealing defects in the respiratory chain. Brain 105: 553

    PubMed  Google Scholar 

  5. Yamamoto T, Beppu H, Tsubaki T (1984) Mitochondrial encephalomyopathy: fluctuating symptoms and CT. Neurology 34: 1456

    PubMed  Google Scholar 

  6. Kuriyama M, Umezaki H, Fukuda Y, Osame M, Koike K, Tateishi J, Igata A (1984) Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions. Neurology 34: 72

    PubMed  Google Scholar 

  7. Ishitsu T, Miike T, Kitano A, Haraguchi Y, Ohtani Y, Matsuda I, Shimoji A, Kimura H (1987) Heterogeneous phenotypes of mitochondrial encephalomyopathy in a single kindred. Neurology 37: 1867

    PubMed  Google Scholar 

  8. Sengers RCA, Trijbels JMF, Bakkeren JAJM, Ruitenbeek W, Janssen AJM, Stadhouders AM, terLaak HJ (1983) Dysmyelination and disturbed metobolism of pyruvate: a case report Eur J Pediatr 140: 127

    PubMed  Google Scholar 

  9. Markesbery WR (1979) Lactic acidemia, mitochondrial myopathy and basal ganglia calcification. Neurology 29: 1057

    PubMed  Google Scholar 

  10. Taverni N, Dal Pozzo G, Arnetol G, Zappoli R (1988) Diagnosis and follow up of mitochondrial encephalomyopathy: CT and MR Studies in almost symetrically distribution (arrows). J Comp Ass Tomography 12: 696

    Google Scholar 

  11. Cole AJ, Kuzniecky R, Karpati G, Carpenter S, Andermann E, Andermann F (1988) Familial myopathy with changes resembling inclusions body myositis and periventricular leukocephalopathy Brain 111: 1025

    PubMed  Google Scholar 

  12. Penner MW, Li KC, Gebarski SS, Allen RJ (1987) MR Imaging of pelizaens-Merzbacher disease. J Comp Ass Tomogr 11: 591

    Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, University Hospital Graz, Austria

    M. M. Millner

  2. Radiologische Universitäts-Klinik, Auenbruggerplatz 9, A-8036, Graz, Austria

    K. A. Hausegger, F. Ebner, F. Flückiger & E. Justich

Authors
  1. K. A. Hausegger
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  2. M. M. Millner
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  3. F. Ebner
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  4. F. Flückiger
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  5. E. Justich
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Hausegger, K.A., Millner, M.M., Ebner, F. et al. Mitochondrial encephalomyopathy — two years follow-up by MRI. Pediatr Radiol 21, 231–233 (1991). https://doi.org/10.1007/BF02011058

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  • DOI: https://doi.org/10.1007/BF02011058

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