Abstract
The elimination kinetics of inorganic blood sulfate in mice was followed for four hours after a single, oral administration of an antirheumatic drug. Sodium salicylate, aspirin, diflunisal and benorylate, all in a dose of 1.25 mmol/kg, reduced the sulfate level to the less than half that of control. This phenomenon was also demonstrated by phenylbutazone, oxyphenbutazone (both 1 mmol/kg), chloroquine diphosphate (0.6 mmol/kg) and tiaprofenic acid (0.02–0.35 mmol/kg). Niflumic acid (1.08 mmol/kg), piroxicam (0.03 mmol/kg), indomethacin (6·10−3 mmol/kg), diclofenac (5·10−3 mmol/kg), ketoprofen (0.2 mmol/kg), naproxen (0.08 mmol/kg) and ibuprofen (0.24 mmol/kg) possessed no sulfate lowering properties. The potential relevance of the use of sulfate lowering drugs for articular cartilage integrity is discussed in the light of what is already known about this subject.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
H. Greiling and B. Schuler, Zur Wirkungsweise der Salizylsäure, Azetylsalizylsäure und des Salizylamids. Z. Rheumaforsch.22, 47–56 (1963).
M. E. Morris and G. Levy,Serum concentration and renal excretion by normal adults of inorganic sulfate after acetaminophen, ascorbic acid, or sodium sulfate. Clin. Pharmacol. Ther.33, 529–536 (1983).
B. J. de Vries, W. B. van den Berg and L. B. A. van de Putte,Salicylate-induced depletion of endogenous inorganic sulfate. Potential role in the suppression of sulfated glycosaminoglycan synthesis in murine articular cartilage. Arthritis Rheum.28, 922–929 (1985).
K. Schimmelpfennig,Problems connected with in vivo labeling of embryonic glycosaminoglycans with Na 2 35 SO 4 in teratological studies. Naunyn Schmiedebergs Arch. Pharmakol.271, 320–324 (1971).
M. E. Morris, O. Kwon and I. L. Mansfield,Sulfate homeostasis. I. Effect of salicylic acid and its metabolites on inorganic sulfate in rats. J. Pharmacol. Exp. Ther.244, 945–949 (1988).
P. K. Halstead and D. A. Roe,Effect of salicylamide on skeletal glycosaminoglycan sulfation and calcification in fetal rat limbs. Drug Nutr. Interact.1, 75–86 (1981).
P. M. van der Kraan, B. J. de Vries, E. L. Vitters, W. B. van den Berg and L. B. A. van de Putte,Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion. Biochem. Pharmacol.37, 3683–3690 (1988).
B. J. de Vries, W. B. van den Berg, E. Vitters and L. B. A. van de Putte,Effects of NSAIDs on the metabolism of sulfated glycosaminoglycans in healthy and (post) arthritic murine articular cartilage. Drugs35 (Suppl. 1), 24–32 (1988).
B. J. de Vries, W. B. van den Berg, E. Vitters and L. B. A. van de Putte,The effect of salicylate on anatomically intact articular cartilage is influenced by sulfate and serum in the culture medium. J. Rheumatol.13, 686–693 (1986).
M. J. Palmoski and K. D. Brandt,Effects of some nonsteroidal antiinflammatory drugs on proteoglycan metabolism and organization in canine articular cartilage. Arthritis Rheum.23, 1010–1020 (1980).
M. W. Whitehouse and H. Boström,The effect of some antiinflammatory (anti-rheumatic) drugs on the metabolism of connective tissues. Biochem. Pharmacol.11, 1175–1201 (1962).
B. J. de Vries, W. B. van den Berg, E. Vitters and L. B. A. van de Putte,Quantitation of glycosaminoglycan metabolism in anatomically intact articular cartilage of the mouse patella: in vitro and in vivo studies with 35 S-sulfate,3 H-glucosamine, and 3 H-acetate. Rheumatol. Int.6, 273–281 (1986).
B. J. de Vries, E. Vitters, W. B. van den Berg, D. Schram and L. B. A. van de Putte,Determination of small quantities of sulfate (0–12 nmol) in serum, urine, and cartilage of the mouse. Anal. Biochem.163, 408–417 (1987).
G. J. Mulder,Sulfation—Metabolic aspects.Prog. Drug Metab.8, 35–100 (1984).
B. J. de Vries, P. M. van der Kraan and W. B. van den Berg,Antirheumatic drugs which decrease serum sulfate are potentially detrimental to articular cartilage. Arthritis Rheum.31, (Suppl.), S69 (Abstract B55), (1988).
H. Greiling and B. Schuler,Die Beeinflussung des Stoffwechsels der Chondroitinschwefelsäure durch anti rheumatisch wirksame Substanzen. InComunicazione al X Congresso della Lega Internazionale contro il Reumatismo. vol. II, pp. 1368–1369, Roma 1961.
H. Boström, K. Berntsen and M. W. Whitehouse,Biochemical properties of anti-inflammatory drugs—I. Some effects on sulphate— 35 S metabolism in vivo. Biochem. Pharmacol.13, 413–420 (1964).
H. Greiling and G. Dörner,Biochemische Untersuchungen zum Wirkungsmechanismus des Resochins. Z. Rheumaforsch21, 316–324 (1964).
J. J. Hjelle, G. A. Hazelton and C. D. Klaassen,Acetaminophen decreases adenosine 3′-phosphate 5′-phosphosulfate and uridine diphosphoglucuronic acid in rat liver. Drug Metab. Dispos.13, 35–41 (1985).
J. A. Waschek, R. M. Fielding, S. M. Pond, G. M. Rubin, D. J. Effeney and T. N. Tozer,Dose-dependent sulfoconjugation of salicylamide in dogs: Effect of sulfate depletion or administration. J. Pharmacol. Exp. Ther.234, 431–434 (1985).
S. Hendrix-Treacy, S. M. Wallace, K. W. Hindmarsh, G. M. Wyant and A. Danilkewich,The effect of acetaminophen administration on its disposition and body stores of sulphate. Eur. J. Clin. Pharmacol.30, 273–278 (1986).
P. M. van der Kraan, E. L. Vitters, B. J. de Vries, W. B. van den Berg and L. B. A. van de Putte,The effect of chronic paracetamol administration to rats on the glycosaminoglycan content of patellar cartilage. Agents and Actions, in press, (1989).
A. Maroudas and H. Evans,Sulphate diffusion and incorporation into human articular cartilage. Biochim. Biophys. Acta338, 265–279 (1974).
M. W. Whitehouse,Biochemical properties of anti-inflammatory drugs-III. Uncoupling of oxidative phosphorylation in a connective tissue (cartilage) and liver mitochondria by salicylate analogues: relationship of structure to activity. Biochem. Pharmacol.13, 319–336 (1964).
W. B. Jakoby, J. R. Bend and J. Caldwell (eds.)Metabolic basis of detoxication, vol. 3, Academic press, New York 1982.
Z. Gregus, C. Madhu and C. D. Klaassen,Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites. J. Pharmacol. Exp. Ther.244, 91–99 (1988).
K. R. Krijgsheld, E. Scholtens and G. J. Mulder,An evaluation of methods to decrease the availability of inorganic sulphate for sulphate conjugation in the rat in vivo. Biochem. Pharmacol.30, 1973–1979 (1981).
J. D. Sallis, T. J. Martin, M. de Luise and R. A. Melick,Relationship of the parathyroids and calcitonin in maintaining sulphate homeostasis. Horm. Metab. Res.2, 238–241 (1970).
J. Rohner and D. Planche,Mechanism of the analgesic effect of calcitonin, evidence for a twofold effect: morphine-like and cortisone-like. Clin. Rheumatol.4, 218–219 (1985).
S. E. Abdullahi, E. A. Martelli, E. Bramm, L. Franco and G. P. Velo,Effect of calcitonin on different inflammatory models. Agents Actions7, 533–538 (1977).
F. Berglund and W. D. Lotspeich,Renal tubular reabsorption of inorganic sulfate in the dog, as affected by glomerular filtration rate and sodium chloride. Am. J. Physiol.185, 533–538 (1956).
G. Herbai,Effect of adrenalectomy, corticosteroids and some other anti-inflammatory agents, salazopyrin, thyroxine and vitamin A on the exchangeable sulphate pool and on sulphate incorporation in vivo into costal cartilage of the mouse. Acta pharmacol. et toxicol.29, 164–176 (1971).
G. Herbai,Effect of pregnancy, castration, testosterone, ethisterone, oestradiol benzoate and stilboestrol on the exchangeable sulphate pool and on sulphate incorporation in vivo into costal cartilage of the mouse. Acta pharmacol. et toxicol.29, 177–193 (1971).
P. Lundquist, J. Mårtensson, B. Sörbo and S. Öhman,Turbidimetry of inorganic sulfate, ester sulfate and total sulfur in urine. Clin. Chem.26, 1178–1181 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
de Vries, B.J., van der Kraan, P.M. & van den Berg, W.B. Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: Potential consequence for articular cartilage. Agents and Actions 29, 224–231 (1990). https://doi.org/10.1007/BF01966451
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01966451