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Pharmacological interactions between ranitidine, cimetidine, metiamide and tiotidine at histamine H2-receptor sites in guinea-pig atria

  • Histamine and Kinins
  • Histamine and the Cardiovascular System
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Abstract

Cumulative concentration-response curves to histamine or dimaprit were constructed on guinea-pig isolated right atria and agonist dose-ratios were determined following addition of ranitidine, cimetidine, metiamide or tiotidine alone or a combination of any two of these H2-receptor blocking drugs. The observed histamine or dimaprit dose-ratios for combinations of any two of the H2-antagonists tested were consistent with results predicted from the equation, DR1+2=DR1+DR2−1, for two antagonists competing for the same receptor sites. Therefore we conclude that all four H2-antagonists compete for the same histamine H2-receptor.

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Authors and Affiliations

  1. Department of Pharmacology, Glaxo Group Research Ltd, SG12 0DJ, Ware, Hertfordshire, UK

    J. M. Humphray, M. J. Daly & R. Stables

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  1. J. M. Humphray
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  2. M. J. Daly
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  3. R. Stables
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Humphray, J.M., Daly, M.J. & Stables, R. Pharmacological interactions between ranitidine, cimetidine, metiamide and tiotidine at histamine H2-receptor sites in guinea-pig atria. Agents and Actions 12, 138–141 (1982). https://doi.org/10.1007/BF01965124

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  • DOI: https://doi.org/10.1007/BF01965124

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