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Du comportement thermique de la khelline

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Abstract

The thermal behaviour of khellin has been studied by thermomicroscopy, differential scanning calorimetry, differential thermal analysis and measurement of transparency. The polymorphism of this drug has been established; the commercial form (I) melting at 153.3° and the form (II) melting at 150.3° have been identified, and their enthalpies (7725±166 cal·mole−1, 6668±230 cal·Mol−1) and entropies (18.17±0.41,15.76± 0.54) of fusion evaluated, while the degree of purity of form (I) has been determined.

Résumé

Le comportement thermique de la khelline a été étudié par thermomicroscopie, analyse calorimétrique différentielle, analyse thermique différentielle et par mesure de la transparence. Le polymorphisme de ce principe actif a été décelé à l'aide des différentes méthodes; la forme commerciale (I) fondant à 153.3° et la forme (II) à 150.3° ont été identifiées, leurs enthalpies (7725±166 cal·mole−1, 6668±230 cal·mol−1), leurs entropies (18.17±0.41, 15.76+0.54) de fusion respectives évaluées, le taux de pureté de la forme (I) déterminé.

Zusammenfassung

Das thermische Verhalten von Khellin wurde durch Thermomikroskopie, Differentialkalorimetrie, Differentialthermoanalyse und Transparenzmessung untersucht. Der Polymorphismus dieses Wirkstoffes wurde an Hand der verschiedenen Methoden gezeigt; die handelsübliche Form (I), welche bei 153.3 °C und die Form (II), welche bei 150.3 °C schmilzt, wurden identifiziert, ihre Enthalpien (7725±166 cal·Mol−1, 6668±230 cal·Mol−1) ihre Schmelz-Enthropien (18.17±0.41, 15.76±0.54) ermittelt und der Reinheitsgrad der Form (I) bestimmt.

Резюме

Изучено термическое поведение хеллина, используя термомикр оскопию, дифференциа льный термический анализ, д ифференциальную ска нирующую калориметрию и степень прозрачност и. Впервые показан пол иморфизм этого препарата, для к оторого идентифицир ованы коммерческая форма (I), п лавящаяся при 153.3° и фор ма (II) — при 150.3°С. Для этих двух форм опр еделены значения энт альпии плавления, равные соо тветственно 7725±166 кал·моль−1 и 6668±230 кал· моль−1, а также энтроп ии плавления разными 18.17±0.41 и 15.76±0.54. Определена сте пень чистоты формы (I).

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Authors and Affiliations

  1. Faculté de Pharmacie, Laboratoire de Chimie Générale et Minérale U. E. R. des Sciences Pharmaceutiques, 34000, Montpellier, France

    J. Masse, R. Malaviolle & A. Chauvet

Authors
  1. J. Masse
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  2. R. Malaviolle
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  3. A. Chauvet
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Masse, J., Malaviolle, R. & Chauvet, A. Du comportement thermique de la khelline. Journal of Thermal Analysis 16, 341–354 (1979). https://doi.org/10.1007/BF01910696

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  • DOI: https://doi.org/10.1007/BF01910696

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