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Efficacy of steroid hormone in solution for intracranial irrigation during aneurysmal surgery for prevention of the vasospasm syndrome

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Summary

A series of 55 patients with ruptured cerebral aneurysms were treated with moderate removal of subarachnoid clot followed by intracranial irrigation with pH 8.0 Hartmann solution containing 1 mg/ml of methylpredonizolone sodium succinate after the aneurysmal clipping during early (before day 3) operation. Six (11%) of the 55 patients suffered vasospasm syndrome postoperatively. The clinical results are significantly better than a series of 68 patients operated on and treated before day 3 by intracranial irrigation with Hartmann solution (pH 8.0) only. The possible preventive effect of direct intracranial administration of steroid hormone is discussed.

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Authors and Affiliations

  1. Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan

    S. Suzuki, K. Ogane, M. Souma, H. Ohkuma & T. Iwabuchi

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  1. S. Suzuki
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  2. K. Ogane
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  3. M. Souma
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  4. H. Ohkuma
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  5. T. Iwabuchi
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Suzuki, S., Ogane, K., Souma, M. et al. Efficacy of steroid hormone in solution for intracranial irrigation during aneurysmal surgery for prevention of the vasospasm syndrome. Acta neurochir 131, 184–188 (1994). https://doi.org/10.1007/BF01808610

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