Abstract
In acute experiments carried out in 27 baboons under general anesthesia, the regional gastric mucosal and muscle layer blood flow and gastric acid secretion were measured during 4 hr. Baboons were allocated to each of the following six groups: control, gastric acid stimulation with histamine 40 Μg/kg/hr intravenous, inhibition of basal or stimulated acid secretion with either ranitidine 50 mg intravenous or omeprazole 1 Μg/kg/hr. There were no significant cardiovascular alterations during the experiments. Histamine stimulation produced a concomitant rise in acid secretion and increase in blood flow only to the mucosal layer of the parietal-cell-bearing area of the stomach. Neither the underlying muscle layer nor the non-parietal-cell-bearing fundic or antral mucosa took part in this response, suggesting that a mechanism controlling blood flow is present in close proximity to the parietal cells. It was also established that the increase in blood flow occurs in response to parietal cell activity and not as a result of the action of histamine on the vascular system. Suppression of both basal and stimulated acid secretion did not cause a fall of mucosal blood flow below basal levels in any part of the stomach, indicating that drugs that inhibit parietal cell activity can be used in conditions where gastric mucosal ischemia should be avoided.
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Peters RM, Womack NA: Haemodynamics of gastric secretion. Ann Surg 148:537–550, 1958
Leonard AS, Engle JC, Peter ET, Long D, Wangensteen OH: Gastric blood flow and inhibition of histamine-stimulated gastric secretion. JAMA 187:589–591, 1964
Delaney JP, Grim E: Experimentally induced variations in canine gastric blood flow and its distribution. Am J Physiol 208(2):353–358, 1965
Jacobson ED, Linford RH, Grossman MI: Gastric secretion in relation to mucosal blood flow studied by a clearance technic. J Clin Invest 45:1–13, 1966
Jacobson ED, Swan KG, Grossman MI: Blood flow and secretion in the stomach. Gastroenterology 52:414–422, 1967
Perry MA, Haedicke GJ, Bulkley GB, Kvietys PR, Granger DN: Relationship between acid secretion and blood flow in the canine stomach: Role of oxygen consumption. Gastroenterology 85:529–534, 1983
Kaufman GL: Blood flow and gastric secretion. Fed Proc 41:2080–2083, 1982
Editorial: Cardiovascular histamine H2 receptors. Lancet 2:421–422, 1982
Knight SE, McIsaac RL, Rennie CD, Flannery MC, Fielding LP: Studies of gastric mucosal blood flow: Neutral red clearance and dose-response curve analysis.In Gastrointestinal Mucosal Blood Flow. LP Fielding (ed). Edinburgh, Churchill Livingstone, 1980, pp 105–124
Heymann MA, Payne BD, Hoffman JIE, Rudolph AM: Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis 20:55–77, 1977
Von Ritter C, Bauerfeind P, Hunter S, Blum AL, Hinder RA: Microspheres (MS) reduce gastric mucosal blood flow (GMBF). Gastroenterology 90:1682, 1986
Gannon B, Browning J, O'Brien P, Rogers P: Mucosal microvascular architecture of the fundus and body of human stomach. Gastroenterology 86:866–875, 1984
Swan KG, Jacobson ED: Gastric blood flow and secretion in conscious dogs. Am J Physiol 212:891–896, 1967
Cheung LY, Lowry SF: Canine gastric blood flow and oxygen consumption during cimetidine inhibition of acid secretion. Surg Forum 27:370–392, 1976
Soll AH: Potentiating interactions of gastric stimulants on [14C]aminopyrine accumulation by isolated canine parietal cells. Gastroenterology 83:216–223, 1982
Shirazi SS, Mueller TM, Hardy BM: Canine gastric acid secretion and blood flow measurement in hemorrhagic shock. Gastroenterology 73:75–78, 1977
Owen DAA, Harvey CA, Johnston BM, Shaw KD: Histamine-induced increase in gastric blood flow in cats: Comparison of findings with different experimental techniques.In Gastro-intestinal Mucosal Blood Flow. LP Fielding (ed). Edinburgh, Churchill Livingstone, 1980, pp 125–131
McIsaac RL: Mucosal blood flow in gastric physiology.In Gastro-intestinal Mucosal Blood Flow. LP Fielding (ed). Edinburgh, Churchill Livingstone, 1980, pp 147–156
Cheung LY, Sonnenschein LA: Effect of cimetidine on canine gastric mucosal pH and blood flow. Am J Surg 145:24–29, 1983
McIsaac RL, Johnston BJ, Fielding LP, Dudley HAF: Basal and dose-response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers. World J Surg 6:427–432, 1982
Delaney JP, Michel HM, Bond J: Cimetidine and gastric blood flow. Surgery 84:190–193, 1978
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Supported by South African Medical Research Council and Swiss National Foundation grant 3.846.0.83.
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Hinder, R.A., Fimmel, C.J., Rickards, E. et al. Stimulation of gastric acid secretion increases mucosal blood flow in immediate vicinity of parietal cells in baboons. Digest Dis Sci 33, 545–551 (1988). https://doi.org/10.1007/BF01798355
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DOI: https://doi.org/10.1007/BF01798355