Summary
Peptides were formed in yields of 5%, 17% and 66%, respectively, when aqueous solutions of glycine, isoleucine or phenylalanine were dried and heated for 24 h at 90°C with adenosine 5′-triphosphate, 4-amino-5-imidazolecarboxamide and cyanamide. Glycine and L-phenylalanine produced mixtures of di-, tri- and tetrapeptides, while L-isoleucine gave only the dipeptide in detectable quantities. The dipeptides of L-isoleucine and L-phenylalanine were identified by mass spectrometry and enzymatic degradation.
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Nooner, D.W., Sherwood, E., More, M.A. et al. Cyanamide mediated syntheses under plausible primitive earth conditions. J Mol Evol 10, 211–220 (1977). https://doi.org/10.1007/BF01764596
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DOI: https://doi.org/10.1007/BF01764596