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Synergism and antagonism induced by three carrier solvents with t-retinoic acid and 6-aminonicotinamide using FETAX

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References

  • Bantle JA, Fort DJ, James BL (1989) Identification of development toxicants using the Frog Embryo TeratogenesisAssay-Xenopus (FETAX). Hydrobiologia 188/189:577–585

    Google Scholar 

  • Chamberlain JG (1966) Development of cleft palate induced by 6-aminonicotinamide late in rate gestation. Anat Rec 156:31–40

    PubMed  Google Scholar 

  • Coetzee JF, Ritchie CD (1969) Solute-solvent interactions. Marcel Dekker Inc, New York

    Google Scholar 

  • Courchesne CL, Bantle JA (1985) Analysis of the activity of DMA, RNA, and protein synthesis inhibitorson Xenopus embryo development. Teratogen, Carcinogen Mutagen 5:177–193

    Google Scholar 

  • Dawson DA, Bantle JA (1987a) Coadministration of methlxanthines and inhibitor compounds potentiates teratogenicity inXenopus embryos. Teratology 35:221–227

    PubMed  Google Scholar 

  • Dawson DA, Bantle JA (1987b) Development of a reconstituted water medium and preliminary validation of the Frog Embryo TeratogenesisAssay-Xenopus (FETAX). J Appl Toxicol 7(4):237–244

    PubMed  Google Scholar 

  • Dawson DA, McCormick CA, Bantle JA (1985) Detection of teratogenic substances in acidic mine water samples using Frog Embryo TeratogenesisAssay-Xenopus (FETAX). J of Appl Toxicol 5(4):234–244

    Google Scholar 

  • Dawson DA, Fort DJ, Newell DL, Bantle JA (1989) Developmental toxicity testing with FETAX: evaluation of five compounds. Drug Chem Toxicol, 12(1):67–75

    PubMed  Google Scholar 

  • Demey HE, Daelemans RA, Verpooten GA, De-Broe ME, Van-Campenhout CM (1983) Propylene glycol-induced side effects during intravenous nitroglycerin therapy. Intensive Care Med 14(3):221–226

    Google Scholar 

  • Dumont JN, Schultz TW, Buchanan M, Kao G (1983) Frog Embryo Teratogenesis Assay:Xenopus (FETAX)--A Short-term Assay applicable to complex environmental mixtures. In: Waters, Sandhu, Lewtas, Claxton, Chernoff, and Nesnow (Eds) Short-term Bioassays in the Analysis of Complex Environmental Mixtures III Plenum Publishing: 393–405

  • Fort DJ, James BL, Bantle JA (1989) Evaluation of the developmental toxicity of five compounds with the Frog Embryo Teratogenesis Assay:Xenopus (FETAX) and a metabolic Activation System. J App Toxicol 9(6), 377–388

    Google Scholar 

  • Gichner T, Veleminsky J (1987) The organic solvents acetone, ethanol and dimethylfor-mamide potentiate the mutagenic activity of N-methyl-N'nitro-N-Nitrosoguanidine, but have no effect on the mutagenic potential of N-Methyl-N-nitrosourea. Mutat Res 192(1):31–35

    PubMed  Google Scholar 

  • Kochhar DM (1975) Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid. Teratology 7:289–298

    Google Scholar 

  • Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Bran JT, Curry CJ, Fernhoff PM, Grix AW, Lott IT, Richard JM, Sun SC (1985) Retinoic acid embryopathy. N Engl J Med 313:837–841

    PubMed  Google Scholar 

  • Nemethy G, (1986) Orientation of amino acid side chains: Intraprotein and solvent interactions. Biomembranes, Part O. protons and water: Structure and translocation. Methods Enzymol 127 (part O):183–195

    PubMed  Google Scholar 

  • Sabourin TD, Faulk RT (1987) Comparative evaluation of a short-term test for developmental effects using frog embryos. Branbury Report 26: Develop Toxicol Mechanisms and Risk. Cold Spring Harbor Laboratory: 203–223

  • Schardein JL, Woosley ET, Peltzer MA, Kaup DH (1967) Congential malformations induced by 6-aminonicotinamide. Biol Neonate 1:106–111

    Google Scholar 

  • Steel GR, Torrie JH (1980) Principles and procedures of statistics: A biometrical approach. McGraw-Hill Book Company New York

    Google Scholar 

  • Tallarida RJ, Murray RB (1980) Manual of pharmacologic calculations with computer programs. Springer-Verlag, New York

    Google Scholar 

  • Wilkinson L (1989) Systat: The system for statistics. Systat lnc.:Evanston IL

    Google Scholar 

  • Yalkowsky SH, (1981) Techniques of solubilization of drugs. Marcel Dekker, Inc. New York

    Google Scholar 

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Rayburn, J.R., Fort, D.J., McNew, R. et al. Synergism and antagonism induced by three carrier solvents with t-retinoic acid and 6-aminonicotinamide using FETAX. Bull. Environ. Contam. Toxicol. 46, 625–632 (1991). https://doi.org/10.1007/BF01688209

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  • DOI: https://doi.org/10.1007/BF01688209

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