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Hydrocephalus due to prenatal infection with the lymphocytic choriomeningitis virus

Hydrozephalus infolge pränataler Infektion durch das LCM-Virus

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Summary

The results are presented of serological examinations in a total of 4235 subjects including blood donors (341 persons), pregnant women (1784), newborns (833), patients with malignant tumours (248), patients with influenza-like diseases (548), patients with abacterial meningitis (295), infants under one year with hydrocephalus (40), infants under two years with other nervous system diseases (110), mothers of seropositive children with hydrocephalus (12) and mothers of seronegative children with hydrocephalus (24). The investigations revealed 16 cases of serologically confirmed prenatal lymphocytic choriomeningitis virus infection. Immunofluorescent antibody to this virus was detected in the children in most cases at high titers and in their mothers at moderate and low titers. In 14 children hydrocephalus was manifest, one child was suffering from infantile cerebral palsy, and one child from congenital right side blepharoptosis. Foci of chorioretinal degeneration were found in 14 patients. During pregnancy six mothers had an influenza-like illness; the other ten mothers denied any disease associated with fever.

Zusammenfassung

Es werden die Ergebnisse serologischer Untersuchungen an insgesamt 4235 Personen dargelegt, darunter Blutspender (341 Personen), Schwangere (1784), Neugeborene (833), Patienten mit malignen Tumoren (248), Patienten mit grippeähnlichen Krankheiten (548), Patienten mit abakterieller Meningitis (295), Kinder unter einem Jahr mit Hydrozephalus (40), Kinder unter zwei Jahren mit anderen Erkrankungen des Nervensystems (110), Mütter von sereopositiven Kindern mit Hydrozephalus (12) und Mütter von seronegativen Kindern mit Hydrozephalus (24). Die Untersuchungen ergaben 16 Fälle von serologisch verifizierter pränataler Infektion durch das LCM-Virus. Ein immunfluoreszierender Antikörper gegen dieses Virus wurde bei den Kindern in den meisten Fällen bei hohen Titern und bei ihren Müttern bei mäßigen und niedrigen Titern festgestellt. Bei 14 Kindern trat Hydrozephalus eindeutig in Erscheinung. Ein Kind litt an zerebralem Kinderlähmungs-Syndrom und ein Kind an angeborener rechtsseitiger Ptosis. Bei 14 Patienten fanden sich Herde chorioretinaler Entartung. Während der Schwangerschaft hatten sechs Mütter grippeähnliche Krankheiten, die restlichen zehn Mütter verneinten jegliche mit Fieber einhergehende Erkrankung.

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  1. Institute of Epidemiology, Microbiology and Hygiene, Ministry of Public Health of the Lithuanian SSR, Gorkio, g-vé 64, 232024, Vilnius, USSR

    M. Sheinbergas

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Sheinbergas, M. Hydrocephalus due to prenatal infection with the lymphocytic choriomeningitis virus. Infection 4, 185–191 (1976). https://doi.org/10.1007/BF01638922

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