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Early effects of experimental arterial subarachnoid haemorrhage on the cerebral circulation part I: Experimental subarachnoid haemorrhage in cat and its pathophysiological effects methods of regional cerebral blood flow measurement and evaluation of microcirculation

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Summary

Studies of pathophysiological changes, regional cerebral blood flow (rCBF) and cerebral microcirculation were performed in cats subjected to arterial subarachnoid haemorrhage (SAH). An original method for SAH imitating aneurysm rupture was developed. The bleeding was induced by puncturing of the internal carotid artery approached tranpresphenoidally and followed by immediate closure of the skull opening. It was found, that arterial subarachnoid bleeding elevates intracranial pressure and results in a transitory fall in cerebral perfusion pressure which is not prevented by elevation of arterial blood pressure (Cushing reflex). A depression in brain electrical activity and respiration rate were present in the course of subarachnoid haemorrhage.

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References

  1. Adams, H. P., Jr., Kassel, N. F., Torner, J. C.,et al., Early management of aneurysmal subarachnoid hemorrhage. A report of the cooperative aneurysm study. J. Neurosurg.54 (1981), 141–145.

    PubMed  Google Scholar 

  2. Akiyama, I., Chigasaki, H., Ischi, S.,et al., Disseminated intravascular coagulation as a risk factor in ruptured intracranial aneurysms. Abstracts of the 7th International Congress of Neurological Surgery, München 1981, Neurochirurgica Suppl., 311.

  3. Ames, A., 3rd, Wright, R. L., Kowada, M.,et al., Cerebral ischaemia II. The no reflow phenomenon. Amer. J. Path.52 (1968), 437–453.

    PubMed  Google Scholar 

  4. Ames, A., 3rd, Incidence and significance of vascular occlusion in focal and diffuse ischemia. Cerebral circulation and metabolism (Langfitt, T. W., McHenry, L. C., Reivich, M.,et al., eds.), pp. 551–554. New York-Heidelberg-Berlin: Springer. 1975.

    Google Scholar 

  5. Asano, T., Sano, K., Pathogenetic role of no-reflow phenomenon in experimental subarachnoid hemorrhage in dogs. J. Neurosurg.46 (1977), 454–466.

    PubMed  Google Scholar 

  6. Baldy-Moulinier, M., Ingvar, D. H., EEG frequency content related to regional blood flow of cerebral cortex in cat. Exp. Brain Res.5 (1968), 55–60.

    Article  PubMed  Google Scholar 

  7. Bergvall, V., Steiner, L., Forster, D. M. C., Early pattern of cerebral circulatory disturbances following subarachnoid haemorrhage. Neuroradiology5 (1973), 24–32.

    PubMed  Google Scholar 

  8. Brodner, R. A., Dohrmann, G. J., Roth, R. H., Rubin, R. A., Correlation of cerebrospinal fluid serotonin and altered spinal cord blood flow in experimental trauma. Surg. Neurol.13 (1980), 337–343.

    PubMed  Google Scholar 

  9. Crompton, M. R., Cerebral infarction following the rupture of cerebral berry aneurysms. Brain87 (1964), 263–279.

    Google Scholar 

  10. Crowell, R. M., Olsson, Y., Observation of the microvasculature in focal cerebral ischemia and infarction. Cerebral Vascular Diseases (McDowell, F. H., Brennan, R. W., eds.), pp. 77–88. New York-London: Grune and Stratton. 1973.

    Google Scholar 

  11. Drake, C. G., Cerebral vascular diseases —an update. 9th Princetown. Conference on Cerebro-Vascular Diseases (Whisnaut, J., Sandock, B. A., eds.). New York: Grune and Stratton. 1979.

    Google Scholar 

  12. Fein, J. M., Brain energetics and circulatory control after subarachnoid hemorrhage. J. Neurosurg.45 (1976), 498–507.

    PubMed  Google Scholar 

  13. Ferguson, G. G., Harper, A. M., Fitch, W., Rowan, J. O., Cerebral blood flow measurements after spontaneous subarachnoid haemorrhage. Europ. Neurol.8 (1972), 15–22.

    PubMed  Google Scholar 

  14. Fischer, E. G., Impaired perfusion following cerebrovascular stasis. A review. Arch. Neurol.29 (1973), 361–366.

    PubMed  Google Scholar 

  15. Fitz-Gerald, J. M., Implications of a theory of erytrocyte motion in narrow capillaries. J. Appl. Physiol.27 (1969), 912–918.

    PubMed  Google Scholar 

  16. Fleischer, A. S., Tindall, G. T., Cerebral vasospasm following aneurysm rupture. A protocol for therapy and prophylaxis. J. Neurosurg.52 (1980), 149–152.

    PubMed  Google Scholar 

  17. Grubb, R. L., Jr., Hernandez-Perez, M. J., Raichle, M. E.,et al., The effects of iodinated contrast agents on autoregulation of cerebral blood flow. Stroke5 (1974), 155–160.

    PubMed  Google Scholar 

  18. Grubb, R. L., Jr., Raichle, M. E., Eichling, J. O., Gado, M. H., Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow, and oxygen utilization in humans. J. Neurosurg.46 (1977), 446–453.

    PubMed  Google Scholar 

  19. Hanau, J., Foncin, J. F., Le Beau, J., On the role of cerebral ischemia in the fatal course of ruptured supratentorial aneurysms. Neurochirurgie15 (1969), 353–368.

    PubMed  Google Scholar 

  20. Hashi, K., Meyer, J. S., Shinmaru, S.,et al., Hemodynamic and metabolic changes in experimental subarachnoid hemorrhage in monkeys. Cerebral blood flow and intracranial pressure. Europ. Neurol.8 (1972), 32–37.

    PubMed  Google Scholar 

  21. Heilbrun, M. P., Olesen, J., Lassen, N. A., Regional cerebral blood flow studies in subarachnoid hemorrhage. J. Neurosurg.37 (1972), 36–44.

    PubMed  Google Scholar 

  22. Hekmatpanah, J., Irreversible damage and cerebral death in increased intracranial pressure. Intracranial pressure (Brock, M., Dietz, H., eds.), pp. 149–154. Berlin-Heidelberg-New York: Springer. 1972.

    Google Scholar 

  23. Hoffmann, O., Mathematische Modelle zur Untersuchung der Liquordynamik. Inaugural-Dissertation. J. L. Universität Giessen, 1980.

  24. Hossmann, K. A., Lechtape-Grüter, H., Blood flow and recovery of the cat brain after complete ischemia for 1 hour. Cerebral blood flow and intracranial pressure. Europ. Neurol.6 (1971/1972), 318–322.

    Google Scholar 

  25. Ishii, R., Regional cerebral blood flow in patients with ruptured intracranial aneurysms. J. Neurosurg.50 (1979), 587–594.

    PubMed  Google Scholar 

  26. Jakubowski, J., McCleary, W. N., Todd, J. H., Smart, R. C., Cerebral blood flow changes in acute experimental haemorrhagic vasospasm. Acta Neurochir. (Wien)34 (1976), 265–268.

    Google Scholar 

  27. Kelly, P. J., Gorton, R. J., Grossman, R. G., Eisenberg, H. M., Cerebral perfusion, vascular spasm, and outcome in patients with ruptured intracranial aneurysms. J. Neurosurg.47 (1977), 44–49.

    PubMed  Google Scholar 

  28. Kety, S. S., Measurement of local circulation within the brain by means of inert diffusible tracers: Examination of the theory, assumptions and possible sources of error. Acta Neurol. Scand., Suppl.14 (1965), 20–23.

    Google Scholar 

  29. Kosnik, E. J., Hunt, W. E., Postoperative hypertension in the management of patients with intracranial arterial aneurysms. J. Neurosurg.45 (1976), 148–154.

    PubMed  Google Scholar 

  30. Landau, W., Freygang, W. H., Jr., Rowland, L. P.,et al., The local circulation of the living brain: values in the unanesthetized and anesthetized cat. Trans. Amer. Neurol., Assoc.80 (1955), 125–129.

    Google Scholar 

  31. Lanfitt, T. W., Kassel, N. F., Non-filling of cerebral vessels during angiography: correlation with intracranial pressure. Acta Neurochir. (Wien)14 (1966), 96–104.

    Article  Google Scholar 

  32. Levitt, P., Wilson, W. P., Wilkins, R. H., The effects of subarachnoid blood on the electrocorticogram of the cat. J. Neurosurg.35 (1971), 185–191.

    PubMed  Google Scholar 

  33. Löfgren, J., Zwetnow, N. N., Kinetics of arterial and venous hemorrhage in the scull cavity. Intracranial pressure (Brock, M., Dietz, H., ed.), pp. 155–159. Berlin-Heidelberg-New York: Springer. 1972.

    Google Scholar 

  34. Martins, A. N., Newby, N., Doyle, T. F.,et al., Effect of subarachnoid injection of blood. J. Neurosurg.44 (1976), 353–358.

    PubMed  Google Scholar 

  35. Methew, N. T., Meyer, J. S., Hartman, A., Diagnosis and treatment of factors complicating subarachnoid hemorrhage. Neuroradiology6 (1974), 237–245.

    Article  PubMed  Google Scholar 

  36. McDowell, D. G., The effects of general anesthetics on cerebral blood flow and cerebral metabolism. Brit. J. Anaesthesia37 (1965), 236–245.

    Google Scholar 

  37. McMurtry, J. G., III, Pool, J. L., Nova, H. R., The use of rheomacrodex in the surgery of intracranial aneurysms. J. Neurosurg.26 (1967), 218–222.

    PubMed  Google Scholar 

  38. Nagai, H., Suzuki, Y., Sugiura, M.,et al., Experimental cerebral vasospasm. Part 1: Factors contributing to early spasm. J. Neurosurg.41 (1974), 285–292.

    PubMed  Google Scholar 

  39. Nornes, H., The role of intracranial pressure in the arrest of hemorrhage in patients with ruptured intracranial aneurysm. J. Neurosurg.39 (1973), 226–234.

    PubMed  Google Scholar 

  40. Nornes, H., Cerebral arterial flow dynamics during aneurysm haemorrhage. Acta Neurochir. (Wien)41 (1978), 39–48.

    Google Scholar 

  41. Nornes, H., Knutzen, H. B., Wikeby, P., Cerebral arterial blood flow and aneurysm surgery. J. Neurosurg.47 (1977), 819–827.

    PubMed  Google Scholar 

  42. Parkes, J. D., James, I. M., Electroencephalographic and cerebral blood flow changes following spontaneous subarachnoid haemorrhage. Brain94 (1971), 69–76.

    PubMed  Google Scholar 

  43. Petruk, K. C., West, G. R., Marriott, M. R.,et al., Cerebral blood flow following induced subarachnoid hemorrhage in the monkey. J. Neurosurg.37 (1972), 316–324.

    PubMed  Google Scholar 

  44. Pia, H. W., Langmaid, C., Zierski, J., (eds.), Cerebral aneurysms. Advances in diagnosis and therapy, p. 434. Berlin-Heidelberg-New York: Springer. 1979.

    Google Scholar 

  45. Pickard, J. D., Matheson, M., Patterson, J., Wyper, D., Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow. J. Neurosurg.53 (1980), 305–308.

    PubMed  Google Scholar 

  46. Potchen, E. J., Davis, D. O., Kilgore, B., Hurley, R., The effect of cerebral arteriography on regional cerebral blood flow measurement. Recent advances in the study of cerebral circulation (Taveras, J. M., Fischgold, H., Dilenge, D., eds.), pp. 103–108. Springfield, Ill.: Ch. C Thomas. 1970.

    Google Scholar 

  47. Pritz, M. B., Giannotta, S. L., Kindt, G. W.,et al., Treatment of patients with neurological deficits associated with cerebral vasospasm by intravascular volume expansion. Neurosurgery3 (1978), 364–368.

    PubMed  Google Scholar 

  48. Reivich, M., Regional cerebral blood flow in physiologic and pathophysiologic states. Progress in Brain Research, Cerebral blood flow, Vol. 35, pp. 1919–1928. Amsterdam: Elsevier. 1972.

    Google Scholar 

  49. Reivich, M., Jehle, J., Sokoloff, L., Kety, S. S., Measurement of regional cerebral blood flow with antipyrine-14C in awake cats. J. Appl. Physiol.27 (1969), 296–300.

    PubMed  Google Scholar 

  50. Rothberg, C., Weir, B., Overton, T., Grace, M., Responses to experimental subarachnoid hemorrhage in the spontaneously breathing primate. J. Neurosurg.52 (1980), 302–308.

    PubMed  Google Scholar 

  51. Sahs, A. L., Nibbelink, D. W., Knowler, L. A., Cooperative aneurysm project: introductory report of a randomized treatment study. Cerebrovascular diseases (McDowell, F. H., Brennan, R. W., eds.), pp. 33–41. New York: Grune-and Stratton. 1973.

    Google Scholar 

  52. Salamon, G., Combalbert, A., Faure, J., Guidicelli, G., Microradiographic study of the arterial circulation of the brain. Cerebral circulation (Luyendijk, W., ed.), pp. 33–41. Amsterdam-London-New York: Elsevier. 1968.

    Google Scholar 

  53. Sandler, A. N., Tator, C. H., Regional spinal cord blood flow in primates. J. Neurosurg.45 (1976), 647–659.

    PubMed  Google Scholar 

  54. Schenck, S. A., On the relationship between ruptured intracranial aneurysm and cerebral infarction. Neurology14 (1961), 691–702.

    Google Scholar 

  55. Simeone, F. A., Trepper, P. J., Brown, D. J., Cerebral blood flow evaluation of prolonged experimental vasospasm. J. Neurosurg.37 (1972), 302–311.

    PubMed  Google Scholar 

  56. Smith, A. L., Wollman, H., Cerebral blood flow and metabolism: effects of anestetic drugs and techniques. Anesthesiology36 (1972), 373–400.

    Google Scholar 

  57. Steiner, L., Löfgren, J., Zwetnow, N., Cerebral blood flow and metabolism in the acute phase of experimental subarachnoid bleed. Zbl. Neurochir.39 (1978), 223–230.

    Google Scholar 

  58. Sundt, T. M., Jr., Management of ischemic complications after subarachnoid hemorrhage. J. Neurosurg.43 (1975), 418–425.

    PubMed  Google Scholar 

  59. Sundt, T. M., Jr., Waltz, A. G., Cerebral ischemia and reactive hyperemia. Circulat. Res.28 (1971), 426–433.

    PubMed  Google Scholar 

  60. Swank, L., Bartsch, W., Influence of aggregated blood cells on cerebrovascular disease. Cerebral circulation and stroke (Zülch, K. J., ed.). Berlin-Heidelberg-New York: Springer.

  61. Symon, L., Disordered cerebro-vascular physiology in aneurysmal subarachnoid haemorrhage. Acta Neurochir. (Wien)41 (1978), 7–22.

    Google Scholar 

  62. Symon, L., Astrup, J., Phenomena associated with focal ischaemia in the central nervous system. Acta Neurochir. (Wien), Suppl.28 (Wien), (1979), 215–217.

    Google Scholar 

  63. Trojanowski, T., Experimental subarachnoid haemorrhage. Part II: Extravasation volume and dynamics of subarachnoid arterial bleeding in cats. Acta Neurochir. (Wien),64 (1982), 103–108.

    Google Scholar 

  64. Voldby, B., Endevoldsen, E. M., Intracranial pressure changes following aneurysm rupture. Part I: Clinical and angiographic correlations. J. Neurosurg.56 (1982), 186–196.

    PubMed  Google Scholar 

  65. Wegner, L. A., Patzschke, K., Zur Bestimmung von14C und3H in Ganzkörper-Schnitten: Methodische Untersuchungen zur Einführung eines neuen Verfahrens. Int. J. Appl. Radiat. Isotopes27 (1976), 573–583.

    Article  Google Scholar 

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  1. T. Trojanowski

    Present address: Department of Neurosurgery, Medical Academy, Lublin, Poland

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  1. Department of Neurosurgery, J. Liebig University, Giessen, Federal Republic of Germany

    T. Trojanowski

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Trojanowski, T. Early effects of experimental arterial subarachnoid haemorrhage on the cerebral circulation part I: Experimental subarachnoid haemorrhage in cat and its pathophysiological effects methods of regional cerebral blood flow measurement and evaluation of microcirculation. Acta neurochir 72, 79–94 (1984). https://doi.org/10.1007/BF01406816

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