Summary
Carbopol, a polymer of acrylic acid cross-linked with allylsucrose, was found to impart resistance to virus infection in mice which received an intraperitoneal injection of the polycarboxylate 1 or 4 days before either intravenous vaccinia virus challenge or intranasal herpes simplex virus challenge. An interferon-like substance was detected in the blood stream 20–40 hours after the intraperitoneal injection of carbopol. The antiviral activity of this cross-linked polycarboxylate could be due to activation of peritoneal macrophages and/or interferon production.
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de Clercq, E., Luczak, M. Antiviral activity of carbopol, a cross-linked polycarboxylate. Archives of Virology 52, 151–158 (1976). https://doi.org/10.1007/BF01317874
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DOI: https://doi.org/10.1007/BF01317874