Skip to main content
SpringerLink
Log in

Identification of a new mumps virus lineage by nucleotide sequence analysis of the SH gene of ten different strains

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

The SH gene and its flanking sequences have been analysed for 10 strains of mumps virus (MuV) and compared to 5 others. A new lineage has been identified among UK isolates. Changes in the transcription pattern could not be correlated with differences in the sequences of the F-SH and SH-HN intergenic regions of the genome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Afzal MA, Elliott GD, Rima BK, Örvell C (1990) Virus and host cell-dependent variation in transcription of the mumps virus genome. J Gen Virol 71: 615–619

    Google Scholar 

  2. Cane PA, Pringle CR (1991) Respiratory syncytial virus heterogeneity during an epidemic: analysis by limited nucleotide sequencing (SH gene) and restriction mapping (N gene). J Gen Virol 72: 349–357

    Google Scholar 

  3. Elango N (1989) Complete nucleotide sequence of the matrix protein mRNA of mumps virus. Virology 168: 426–428

    Google Scholar 

  4. Elango N, Kövamees J, Varsanyi TM, Norrby E (1989) Mumps virus: cDNA cloning and characterisation of six genes, determination of gene order and intergenic sequences. In: Kolakofsky D, Mahy B (eds) Genetics and pathogenicity of negative strand viruses. Elsevier, Amsterdam, pp 249–253

    Google Scholar 

  5. Elliott GD, Afzal MA, Martin SJ, Rima BK (1989) Nucleotide sequence of the matrix, fusion and putative SH protein genes of mumps virus and their deduced amino acid sequences. Virus Res 12: 61–75

    Google Scholar 

  6. Elliott GD, Yeo RP, Afzal MA, Simpson EJB, Curran JA, Rima BK (1990) Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1(V) and NS2. J Gen Virol 71: 1555–1560

    Google Scholar 

  7. Forsey T, Mawn JA, Yates PI, Bentley ML, Minor PD (1990) Differentiation of vaccine and wild mumps virus using the polymerase chain reaction and dideoxynucleotide sequencing. J Gen Virol 71: 987–990

    Google Scholar 

  8. Hiebert SW, Paterson RG, Lamb RA (1985) Identification and predicted sequence of a previously unrecognized small hydrophobic protein, SH, of the paramyxovirus simian virus 5. J Virol 55: 744–751

    Google Scholar 

  9. Hiebert SW, Richardson CD, Lamb RA (1988) Cell surface expression and orientation of the 44 amino acid SH protein of simian virus 5. J Virol 62: 2347–2357

    Google Scholar 

  10. Higgins DG, Sharp PM (1988) Clustal: a package for performing multiple sequence alignment on a microcomputer. Gene 73: 237–244

    Google Scholar 

  11. Kawano M, Bando H, Ohgimoto S, Kondo K, Tsurudome M, Nishio M, Yasuhiko I (1990) Sequence of the fusion protein gene of Human Parainfluenza type 2 virus and its 3′ intergenic region: lack of small hydrophobic (SH) gene. Virology 178: 289–292

    Google Scholar 

  12. Kövamees J, Rydbeck R, Örvell C, Norrby E (1990) Hemagglutinin-neuraminidase (HN) amino acid alterations in neutralization escape mutants of Kilham mumps virus. Virus Res 17: 119–130

    Google Scholar 

  13. Merz DC, Server AC, Waxham MN, Wolinsky JS (1983) Biosynthesis of mumps virus F glycoprotein: non-fusing strains efficiently cleave the F glycoprotein precursor. J Gen Virol 64: 1457–1467

    Google Scholar 

  14. Tanabayashi K, Takeuchi K, Hishiyama M, Yamada A, Tsurudome M, Sugiura A (1990) Nucleotide sequence of the leader and nucleocapsid protein gene of mumps virus and epitope mapping with the in vitro expressed nucleocapsid protein. Virology 177: 124–130

    Google Scholar 

  15. Takeuchi K, Tanabayashi K, Hishiyama M, Yamada A, Sugiura A (1989) Cloning and sequencing of the fusion protein gene of mumps virus (Miyahara strain). Nucleic Acid Res 17: 5839

    Google Scholar 

  16. Takeuchi K, Tanabayashi K, Hishiyama M, Yamada A, Sugiura A (1991) Variations of nucleotide sequences and transcription of the SH gene among mumps virus strains. Virology 181: 364–366

    Google Scholar 

  17. Taylor MJ, Godfrey E, Baczko K, ter Meulen V, Wild TF, Rima BK (1991) Identification of several different lineages of measles virus. J Gen Virol 72: 83–88

    Google Scholar 

  18. Turner PC, Forsey T, Minor PD (1991) Comparison of the nucleotide sequence of the SH gene and flanking regions of mumps vaccine virus (Urabe strain) grown on different substrates and isolated from vaccines. J Gen Virol 72: 435–437

    Google Scholar 

  19. van Wyke Coelingh KL, Winter CC, Murphy BR (1988) Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza virus isolated from 1957 to 1983. Virology 162: 137–143

    Google Scholar 

  20. Waxham MN, Aronowski J, Server AC, Wolinsky JS, Smith JA, Goodman HM (1988) Sequence determination of the mumps virus HN gene. Virology 164: 318–325

    Google Scholar 

  21. Wolinsky JS, Waxham MN (1990) Mumps virus. In: Fields BN, Knipe DM, et al (eds) Virology. Raven Press, New York, pp 989–1011

    Google Scholar 

  22. Yamada A, Takeuchi K, Tanabayashi K, Hishiyama M, Sugiura A (1989) Sequence variation of the P gene among mumps virus strains. Virology 72: 374–376

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Genetic Engineering, The Queen's University of Belfast, Belfast, UK

    R. P. Yeo & B. K. Rima

  2. Division of Virology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK

    M. A. Afzal & T. Forsey

Authors
  1. R. P. Yeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Afzal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Forsey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. K. Rima
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yeo, R.P., Afzal, M.A., Forsey, T. et al. Identification of a new mumps virus lineage by nucleotide sequence analysis of the SH gene of ten different strains. Archives of Virology 128, 371–377 (1993). https://doi.org/10.1007/BF01309447

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01309447

Keywords

Search

Navigation