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Observations on growth of virus and the energy-yielding activities of the host cell

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Summary

  1. 1.

    Tissue culture techniques have been applied in many studies on factors influencing the growth of animal viruses.

  2. 2.

    Results with various substances which inhibit influenza virus in tissue cultures are summarized and possible modes of action considered. The effects under consideration are reversible and do not result from death of the tissue or inactivation of the virus.

  3. 3.

    Studies on the mode of action of aromatic diamidines on influenza virus are presented-in some detail.

  4. 4.

    Dinitrophenol, a substance which uncouples phosphorylation from oxidation temporarily interferes with the growth of influenza virus in chorioallantoic membrane tissue without affecting respiration.

  5. 5.

    Growth of influenza virus was found to be dependent on depletable substances in tissue and on glucose in the medium. The latter could be partially replaced by pyruvate.

  6. 6.

    The possible dependence of virus growth on readily available sources of energy and on transfer of energy by phosphorylation is discussed. Interference with synthesis of high energy phosphate by the host cell is considered as an explanation of the local inhibition of viral growth by a variety of substances.

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Bibliography

  1. Cohen, S. S.: Bacteriological Reviews15, 131 (1951).

    Google Scholar 

  2. Luria, S. E.: Chapter 1 in “Viruses 1950” published by California Institute of Technology, Pasadena 4, California.

  3. Rafelsen, M. E. Jr., H. E. Pearson, andR. J. Winzler, Science112, 231 (1950).

    Google Scholar 

  4. Rafelson, M. E. Jr., J. R. Winzler andH. E. Pearson: J. Biol. Chem.193, 205 (1951).

    Google Scholar 

  5. Cohn, Z. A.: Proc. Soc. Exp. Biol. & Med.79, 566 (1952).

    Google Scholar 

  6. Eaton, M. D., F. S. Cheever andC. G. Levenson: J. Immunol66, 463 (1951).

    Google Scholar 

  7. Eaton, M. D., C. G. Levenson andM. E. Perry: J. Immunol68, 1 (1952).

    Google Scholar 

  8. Eaton, M. D., M. E. Perry, C. G. Levenson andI. M. Gocke: J. Immunol68, 321 (1952).

    Google Scholar 

  9. Watson, B. K.: Proc. Soc. Exp. Biol. & Med.79, 222 (1952).

    Google Scholar 

  10. Godh, R. S., Ph. D. Thesis: Graduate School of Arts and Sciences, Division of Medical Sciences, Harvard University.

  11. Bernkopf, H.: Proc. Soc. Exp. Biol.& Med.72, 680 (1949).

    Google Scholar 

  12. Daniels, J., M. D. Eaton andM. E. -Perry: J. Immunol. (1952) in press.

  13. Eaton, M. D., B. Magasanik, M. E. Perry andD. Karibian: Proc. Soc. Exp. Biol. & Med.77, 505 (1951).

    Google Scholar 

  14. Ackermann, W. W.: J. Biol. Chem.189 421 (1951).

    Google Scholar 

  15. Ackermann, W. W.: J. Exp. Med.93, 337 (1951).

    Google Scholar 

  16. Kalter, S. S. andJ. Teppermann: J. Science115, 621 (1952).

    Google Scholar 

  17. Ackermann, W. W.: J. Exp. Med.93, 635 (1951).

    Google Scholar 

  18. Umbarger, H. E. andB. Magasanik: J. Am. Chem. Soc. (1952) in press.

  19. Schoenbach, E. B. andE. M. Greenspan: Medicine27, 327 (1948).

    Google Scholar 

  20. Bernheim, F.: Science98, 223 (1943).

    Google Scholar 

  21. Bernheim, F.: J. Pharm. & Exp. Therap.80, 199–203 (1944).

    Google Scholar 

  22. Blashko, H. andR. Duthie: Biochem. J.39, 347 (1945).

    Google Scholar 

  23. Dickens, F.: Biochem. J.33, 2017 (1939).

    Google Scholar 

  24. Gemmil, C. L.: J. Pharm. & Exp. Therap.95, 173 (1949).

    Google Scholar 

  25. Elson, W. O.: J. Biol. Chem.154, 717 (1944) J. Infect. Dis.76, 193 (1945).

    Google Scholar 

  26. Bichowsky, L.: Proc. Soc. Exp. Biol. & Med.57, 163 (1944).

    Google Scholar 

  27. Dickens, F.: In Sumner and Myrbach “The Enzymes” Vol. II, part 1 p. 624 (1951) Academic Press, New Rork.

    Google Scholar 

  28. Lynen, F.: Ann.546, 120 (1941) Naturwiss.30, 398 (1942).

    Google Scholar 

  29. Johnson, M. J.: Science94, 200 (1941).

    Google Scholar 

  30. Lipmann, F.: personal communication.

  31. Lardy, H. A.: “Respiratory Enzymes” p. 180 (1949) Burgess Publishing Co., Minneapolis 15, Minn.

    Google Scholar 

  32. Weller, T. H. andJ. F. Enders: Proc. Soc. Exp. Biol. & Med.69, 124 (1948).

    Google Scholar 

  33. V. Magnus: Ark. kem., mineral, o geol.24 B, No. 7, 1 (1947).Henle: J. Immunol64, 203 (1950).Bernkopf, H. J.: Immunol65 571 (1950).

    Google Scholar 

  34. Kaplan, M. O.: In Sumner and Myrbach „The Enzymes” Vol. II, part 1 p. 55 (1951) Academic Press, New York.

    Google Scholar 

  35. Loomis, W. F. andF. Lipmann: J. Biol. Chem.173, 807 (1948).

    Google Scholar 

  36. Hotchkiss, R. D.: In “Advances in Enzymology” Vol.4, p. 153 (1946). Interscience Publishers, Inc., New York.

    Google Scholar 

  37. Krahl, M. E. andG. A. H. Clowes: J. Gen. Physiol.20 173 (1936).

    Google Scholar 

  38. Loomis, W. F.: Science,111, 474 (1950).

    Google Scholar 

  39. Loomis, W. F. andF. Lipmann: J. Biol. Chem.179, 503 (1949).

    Google Scholar 

  40. Heagy, F. C.: J. Bact.59, 367 (1950).

    Google Scholar 

  41. Foster, R. A. C.: J. Bact.56, 795 (1948).

    Google Scholar 

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Authors and Affiliations

  1. Department of Bacteriology and Immunology Harvard Medical School, Boston, Mass

    Monroe D. Eaton

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  1. Monroe D. Eaton
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Additional information

This work was supported in part by grants from The Rockefeller Foundation, the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service and the Eugene Higgins Trust.

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Eaton, M.D. Observations on growth of virus and the energy-yielding activities of the host cell. Archiv f Virusforschung 5, 53–72 (1952). https://doi.org/10.1007/BF01245139

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  • DOI: https://doi.org/10.1007/BF01245139

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