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Spectrophotometric determination of ethionamide and thionicotinamide with osmic acid

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Spectrophotometric Determination of Ethionamide and Thionicotinamide with Osmic Acid

A new selective spectrophotometric method of determining micro-amounts of ethionamide and thionicotinamide is described based on the reaction of these compounds with osmic acid.

The stoichiometry of the complex was found to be 1∶1. The application range of the method is from 0.25 to 40μg/ml for ethionamide and from 0.25 to 30μg/ml for thionicotinamide. Ethionamide can be determined in pharmaceutical dragees containing other components. Thionicotinamide and ethionamide can both be determined in mixtures containing a large excess of nicotinic and isonicotinic acids and vitamine PP.

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Authors and Affiliations

  1. Department of Chemistry, Bialystok Technical University, Bialystok, Poland

    Halina Sikorska-Tomicka

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  1. Halina Sikorska-Tomicka
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Sikorska-Tomicka, H. Spectrophotometric determination of ethionamide and thionicotinamide with osmic acid. Mikrochim Acta 87, 151–157 (1985). https://doi.org/10.1007/BF01196996

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  • DOI: https://doi.org/10.1007/BF01196996

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