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Changes in atrial natriuretic factor and plasma renin activity in dogs infected withTrypanosoma brucei

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Abstract

When beagle dogs were infected withTrypanosoma brucei, a marked reduction in the plasma concentration of atrial natriuretic factor (ANF) occurred in the terminal stage of the disease during weeks 3 and 4. At the same time there was an increase in plasma renin activity (PRA) after infection. Ultrastructural studies of the atria of these dogs demonstrated a reduction in ANF granules. The changes in ANF and PRA occurred in association with severe pancarditis and the development of heart failure. By impairing the ability of the heart and kidneys to regulate blood volume, the alterations in ANF and PRA could be involved in the pathogenesis of heart failure inT. brucei-infected dogs.

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Authors and Affiliations

  1. Kenya Trypanosomiasis Research Institute, Muguga P.O. Box 362, Kikuyu, Kenya

    J. M. Ndung'u

  2. University of Glasgow Veterinary School, Bearsden Road, Bearsden, G61 1 QH, Glasgow, Scotland

    N. G. Wright, F. W. Jennings & Max Murray

Authors
  1. J. M. Ndung'u
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  2. N. G. Wright
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  3. F. W. Jennings
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  4. Max Murray
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Additional information

These investigations received support from the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. The dags were kept at Glasgow University Veterinary School. The senior author (J.M.N.) was on a British Council scholarship

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Ndung'u, J.M., Wright, N.G., Jennings, F.W. et al. Changes in atrial natriuretic factor and plasma renin activity in dogs infected withTrypanosoma brucei . Parasitol Res 78, 553–556 (1992). https://doi.org/10.1007/BF00936451

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  • DOI: https://doi.org/10.1007/BF00936451

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