Summary
The in vivo effects of a range of concentrations of praziquantel (10, 25, 50, 100, 200 and 500 mg/kg body weight of mouse) on the tegumental surface of adultSchistosoma mansoni were studied using scanning electron microscopy. Worms were recovered from mice at 1 and 4h post-treatment.
In general, irrespective of the dose level, male worms exhibited more pronounced and extensive surface alterations which included surface bledding, swellings, wrinkling and constrictions and surface lesions, particularly on the spined tubercles.
In male worms, in particular, the number of worms exhibiting damage and the amount of tegumental surface damage depended, mainly, on the concentration of praziquantel, although, at any given dose level, the extent of the damage increased with time post-treatment.
Similar content being viewed by others
References
Andrews P (1976) Pharmacokinetic studies with Droncit in animals using a biological assay. Vet Med Rev 10:145–165
Andrews P (1981) A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action. Arzneim Forsch/Drug Res 31:538–541
Becker B, Mehlhorn H, Andrews P, Eckert J (1980) Light and electron microscopic studies on the effect of praziquantel onSchistosoma mansoni, Dicrocoelium dentriticum andFasciola hepatica (Trematoda) in vitro. Z Parasitenkd 63:113–128
Duvall RH, Dewitt WB (1967) An improved perfusion technique for recovering adult schistosomes from laboratory animals. Am J Trop Med Hyg 16:483–486
Gönnert R, Andrews P (1977) Praziquantel, a new broad-spectrum antischistosomal agent. Z Parasitenkd 52:129–150
Hillman GR, Gibler WB, Anderson JB (1977) Comparative effects of hycanthone inSchistosoma mansoni andSchistosoma japonicum. Am J Trop Med Hyg 26:238–242
Hockley DJ (1973) Ultrastructure of the tegument of Schistosoma. Adv Parasitol 11:233–305
Kohn A, Lopez-Alvarez ML, Katz N (1982) Transmission and scanning electron microscopical studies in the tegument of maleSchistosoma mansoni after oxamniquine treatment. Ann Parasitol Hum Comp 57:285–291
McLaren DJ (1980)Schistosoma mansoni: The parasite surface in relation to host immunity. In: Tropical Medicine Research Studies 1. Research Studies Press: John Wiley Press, Chichester.
Mehlhorn H, Becker B, Andrews P, Thomas H, Frenkel JK (1981) In vivo and in vitro experiments on the effects of praziquanted onSchistosoma mansoni. Arzneim Forsch/Drug Res 31:544–554
Oyerinde JPO (1976) The effects of 1, 7 bis (p-aminophenoxy) heptane on adultSchistosoma mansoni in mice. Nigerian Med J 6:392–397
Patzschke K, Putter J, Wegner LA, Horster FA, Diekmann HW (1979) Serum concentrations and renal excretion in humans after oral administration of praziquantel-results of three determination methods. Eur J Drug Metab Pharmacokinet 4: 149–156
Pellegrino J, Lima-Costa FF, Carlos MA, Mello RT (1977) Experimental chemotherapy of Schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters andCebus monkeys. Z Parasitenkd 52:151–168
Perez H, Terry RJ (1973) The killing of adultSchistosoma mansoni in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. Int J Parasitol 3:499–503
Shaw MK, Erasmus DA (1982)Schistosoma mansoni: effects of praziquantel on the ultrastructure of worms in vivo. Trans R Soc Trop Med Hyg 76:528
Shaw MK, Erasmus DA (1983)Schistosoma mansoni: The effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo. Z Parasitenkd 69:73–90
Smithers SR, Terry RJ (1965) Infection of laboratory hosts with cercariae ofSchistosoma mansoni and the recovery of adult worms. Parasitology 55:695–700
Steiner K, Garbe A, Diekmann HW, Nowak H (1976) The fate of praziquantel in the organism. I. Pharmacokinetics in animals. Eur J Drug Metab Pharmacokinet 2:85–95
Voge M, Bueding E (1980)Schistosoma mansoni: tegumental surface alterations induced by subcurative doses of the schistosomicide amoscanate. Exp Parasitol 50:251–259
Watts SDM, Orpin A, MacCormick C (1979) Lysosomes and tegument pathology in the chemotherapy of schistosomiasis with 1,7-bis (p-aminophenoxy) heptane (153 C51). Parasitology 78:287–294
Webbe G, James C (1977) A comparison of the susceptibility to praziquantel ofSchistosoma haematobium, S. japonicum, S. mansoni, S. intercalatum andS. mattheei in hamsters. Z Parasitenkd 52:169–177
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shaw, M.K., Erasmus, D.A. Schistosoma mansoni: Dose-related tegumental surface changes after in vivo treatment with praziquantel. Z. Parasitenkd. 69, 643–653 (1983). https://doi.org/10.1007/BF00926674
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00926674