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A review of psychophysiological research with hyperkinetic children

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Abstract

A number of studies have appeared which focus on the issue of whether hyperactive children are psychophysiologically different from normal children and what impact the stimulant drugs may have on psychophysiological characteristics of these children. The present paper reviews these studies under the type of measures that were employed. In general, the results suggest that hyperactive children are probably not under or overaroused in their resting levels of autonomic functions, although some children may display resting cortical underarousal. However, the findings of studies on the impact of stimulation on autonomic or central functions intimate that some hyperactive children are probably underreactive to environmental stimulation, or are “underarousable.” Indeed, where differences between hyperactive and normal children are found in such evoked-response studies, they are consistently in this direction of “underarousability.” Results for the effects of stimulant drugs suggest that these drugs energize or increase the “arousal” of these children and enhance the impact of stimulation on the nervous system. The implications of these results for current theories of hyperactivity and for future research are discussed.

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References

  • Aman, M. G., & Werry, J. S. The effects of methylphenidate and haloperidol on the heart rate and blood pressure of hyperactive children with special reference to time of action.Psychopharmacologia, 1915,43, 163–168.

    Google Scholar 

  • Arnold, L. E., Wender, P. H., McCloskey, K., & Snyder, S. H. Levoamphetamine and dextroamphetamine: Comparative efficacy in the hyperkinetic syndrome.Archives of General Psychiatry, 1972,27, 816–822.

    Google Scholar 

  • Ballard, J. E., Boileau, R. A., Sleator, E. K., Massey, B. H., & Sprague, R. L. Cardiovascular responses of hyperactive children to methylphenidate.Journal of the American Medical Association, 1916,236, 2870–2874.

    Google Scholar 

  • Barkley, R. A. Predicting the response of hyperkinetic children to stimulant drugs.Journal of Abnormal Child Psychology, 1976,4, 327–348.

    Google Scholar 

  • Barkley, R. A. A review of stimulant drug research with hyperactive children.Journal of Child Psychology and Psychiatry, 1977,18, 137–165.

    Google Scholar 

  • Barkley, R. A., & Cunningham, C. E. The effects of Ritalin on the mother-child interactions of hyperactive children.Archives of General Psychiatry, 1978, in press.

  • Barkley, R. A., & Jackson, T. L., Jr. Hyperkinesis, autonomic nervous system activity, and stimulant drug effects.Journal of Child Psychology and Psychiatry, 1977,18, 247–357.

    Google Scholar 

  • Barkley, R. A., & Ullman, D. G. A comparison of objective measures of activity and distractibility in hyperactive and non-hyperactive children.Journal of Abnormal Child Psychology, 1975,3, 231–244.

    Google Scholar 

  • Boileau, R. A., Ballard, J. E., Sprague, R. L., Sleator, E. K., & Massey, B. H. Effect of methylphenidate on cardiorespiratory responses in hyperactive children.Research Quarterly, 1976,47, 590–596.

    Google Scholar 

  • Boydstun, J. A., Ackerman, P. T., Stevens, D. A., Clements, S. D., Peters, J. E., & Dykman, R. A. Physiologic and motor conditioning and generalization in children with minimal brain dysfunction.Conditioned Reflex, 1968,3, 81–104.

    Google Scholar 

  • Buchsbaum, M., & Wender, P. Average evoked responses in normal and minimally brain dysfunctioned children treated with amphetamine.Archives of General Psychiatry, 1973,29, 764–770.

    Google Scholar 

  • Carpenter, R. L., & Sells, C. J. Measuring effects of psychoactive medication in a child with a learning disability.Journal of Learning Disabilities, 1974,7, 545–550.

    Google Scholar 

  • Cohen, N. J., & Douglas, V. I. Characteristics of the orienting response in hyperactive and normal children.Psychophysiology, 1972,9, 238–245.

    Google Scholar 

  • Cohen, N. J., Douglas, V. I., & Morgenstern, G. The effect of methylphenidate on attentive behavior and autonomic activity in hyperactive children.Psychopharmacologia, 1971,22, 282–294.

    Google Scholar 

  • Conners, C. K. Pharmacotherapy of psychopathology in children. In H. Quay & J. Werry (Eds.),Psychopathological disorders of childhood. New York: Wiley, 1972. (a)

    Google Scholar 

  • Conners, C. K. The effect of pemoline and dextroamphetamine on evoked potentials under two conditions of attention. In C. Conners (Ed.),Clinical use of stimulant drugs in children. Amsterdam: Excerpta Medica, 1972. (b)

    Google Scholar 

  • Conners, C. K. Minimal brain dysfunction and psychopathology in children. In A. Davids (Ed.),Child personality and psychopathology: Current topics (Vol. 2). New York: Wiley, 1975.

    Google Scholar 

  • Conners, C. K., Taylor, E., Meo, G., Kurtz, M. A., & Fournier, M. Magnesium pemoline and dextroamphetamine: A controlled study in children with minimal brain dysfunction.Psychopharmacologia, 1912,26, 321–326.

    Google Scholar 

  • Cruickshank, W., Bentzen, F., Ratzburg, D., & Tannhauser, M.A teaching method for braininjured and hyperactive children. New York: Syracuse University Press, 1961.

    Google Scholar 

  • Cunningham, C. E., & Barkley, R. A. The interactions of normal and hyperactive children with their mothers in free play and structured tasks.Child Development, 1978, in press.

  • Douglas, V. I. Stop, look, and listen: The problem of sustained attention and impulse control in hyperactive and normal children.Canadian Journal of Behavioral SCience, 1972,4, 259–282.

    Google Scholar 

  • Duffy, E.Activation and behavior. New York: Wiley, 1962.

    Google Scholar 

  • Epstein, L. C., Lasagna, L., Conners, C. K., & Rodriguez, A. Correlation of dextroamphetamine excretion and drug response in hyperkinetic children.Journal of Nervous and Mental Disease, 1968,146, 136–146.

    Google Scholar 

  • Firestone, P., & Douglas, V. The effects of reward and punishment on reaction times and autonomic activity in hyperactive and normal children.Journal of Abnormal Child Psychology, 1975,3, 201–215.

    Google Scholar 

  • Fish, B. The “one-child, one-drug” myth of stimulants and hypetkinesis.Archives of General Psychiatry, 1971,25, 193–203.

    Google Scholar 

  • Forehand, R., & Baumeister, A. Effects of variations in auditory-visual stimulation on activity-levels of severe mental retardates.American Journal of Mental Deficiency, 1970,74, 470–474.

    Google Scholar 

  • Friebergs, V., & Douglas, V. I. Concept learning in hyperactive and normal children.Journal of Abnormal Psychology, 1969,74, 388–395.

    Google Scholar 

  • Gardner, W., Cromwell, R., & Foshee, J. Studies in activity level. II. Effects of distal visual stimulation in organics, familials, and hyperactives and hypoactives.American Journal of Mental Deficiency, 1959,63, 1028–1033.

    Google Scholar 

  • Gastaut, H. Combined photic and metrazol activation of the brain.Electroencephalography and Clinical Neurophysiology, 1950,2, 249–258.

    Google Scholar 

  • Greenfleld, N., & Sternbach, R.Handbook of psychophysiology. New York: Holt, Rinehart & Winston, 1972.

    Google Scholar 

  • Grunewald-Zuberbier, E., Grunewald, G., & Rasche, A. Hyperactive behavior and EEC arousal reactions in children.Electroencephalography and Clinical Neurophysiology, 1975,38, 149–159.

    Google Scholar 

  • Haig, J. R., Schroeder, C. S., & Schroeder, S. R. Effects of methylphenidate on hyperactive children's sleep.Psychopharmacologia, 1974,27, 185–188.

    Google Scholar 

  • Hall, R. A., Griffin, R. B., Moyer, D. L., Hopkins, K. H., & Rappoport, M. Evoked potential, stimulus intensity, and drug treatment in hyperkinesis.Psychophysiology, 1976,13, 405–415.

    Google Scholar 

  • Halliday, R., Rosenthal, J. H., Naylor, H., & Callaway, E. Averaged evoked potential predictors of clinical improvement in hyperactive children treated with methylphenidate: An initial study and replication.Psychophysiology, 1976,13, 429–439.

    Google Scholar 

  • Johnson, L., & Landon, M. Eccrine sweat gland activity and skin conductance.Psychophysiology, 1965,1, 322–329.

    Google Scholar 

  • Johnson, L., & Lubin, A. The orienting response during waking and sleeping.Electroencephalography and Clinical Neurophysiology, 1967,22, 11–21.

    Google Scholar 

  • Knights, R. M., & Hinton, G. G. The effects of methylphenidate (Ritalin) on the motor skills and behavior of children with learning problems.Journal of Nervous and Mental Disease, 1969,148, 643–653.

    Google Scholar 

  • Knights, R. M., & Viets, C. A. Effects of pemoline on hyperactive boys.Pharmacology, Biochemistry, and Behavior, 1915,3, 1107–1114.

    Google Scholar 

  • Knopp, W., Arnold, L. E., Andras, R. L., & Smeltzer, D. J. Predicting amphetamine response in hyperkinetic children by electronic pupillography.Pharmakopsychiatry, 1973,6, 158–166.

    Google Scholar 

  • Lacey, J. Somatic response patterning and stress: Some revisions of activation theory. In M. Appley & R. Trumbull (Eds.),Psychological stress: Issues in research. New York: Appleton-Century-Crofts, 1967.

    Google Scholar 

  • Lacey, J., & Lacey, B. Verification and extension of the principle of autonomic response stereotypy.American Journal of Psychology, 1958,71, 50–73.

    Google Scholar 

  • Langhorne, J., Jr., Loney, J., Paternite, C., & Bechtholdt, H. Childhood hyperkinesis: A return to the source.Journal of Consulting and Clinical Psychology, 1976,85, 201–209.

    Google Scholar 

  • Laufer, M. W., Denhoff, E., & Solomons, G. Hyperkinetic impulse disorder in children's behavior problems.Psychosomatic Medicine, 1957,19, 38–49.

    Google Scholar 

  • Lindsley, D. B., & Henry, C. E. The effect of drugs on behavior and the electroencephalogram of children with behavior disorders.Psychosomatic Medicine, 1942,4, 140–149.

    Google Scholar 

  • Montagu, J. D. The hyperkinetic child: A behavioral, electrodermal, and EEG investigation.Developmental Medicine and Child Neurology, 1975,17, 299–305.

    Google Scholar 

  • Montagu, J. D.,& Swarbrick, L. Effect of amphetamines in hyperkinetic children: Stimulant or sedative? A pilot study.Developmental Medicine and Child Neurology, 1975,15, 293–298.

    Google Scholar 

  • Nahas, A. E., & Krynicki, V. Effect of methylphenidate on sleep states and ultradian rhythms in hyperactive children.Journal of Nervous and Mental Disease, 1977,164, 66–69.

    Google Scholar 

  • Ojemann, G., & Van Buren, J. Respiratory, heart rate, and GSR responses from the human diencephalon.Archives of Neurology, 1967,16, 64–78.

    Google Scholar 

  • Paine, R., Werry, J. S., & Quay, H. C. A study of “minimal cerebral dysfunction.”Developmental Medicine and Child Neurology, 1968,10, 505–520.

    Google Scholar 

  • Forges, S. W., Walter, G. F., Korb, R. J., & Sprague, R. L. The influence of methylphenidate on heart rate and behavioral measures of attention in hyperactive children.Child Development, 1915,46, 727–733.

    Google Scholar 

  • Prichep, L. S., Sutton, S., & Hakarem, G. Evoked potentials in hyperkinetic and normal children under certainty and uncertainty: A placebo and methylphenidate study.Psychophysiology, 1976,13, 419–428.

    Google Scholar 

  • Rapoport, J. L., Buchsbaum, M., Zahn, T., Weingartner, H., Ludlow, C., & Mikkelsen, E. Dextroamphetamine: Cognitive and behavioral effects in normal prepubertal boys.Science, 1978,199, 511–514.

    Google Scholar 

  • Rapoport, J. L., Quinn, P. O., Bradbard, G., Riddle, D., & Brooks, E. Imipramine and methylphenidate treatments of hyperactive boys.Archives of General Psychiatry, 1974,30, 789–793.

    Google Scholar 

  • Reardon, D., & Bell, G. Effects of sedative and stimulative music on activity levels of severely retarded boys.American Journal of Mental Deficiency, 1970,75, 156–159.

    Google Scholar 

  • Rie, H. E., Rie, E. D., Stewart, S., & Ambuel, J. P. Effects of methylphenidate on underachieving children.Journal of Consulting and Clinical Psychology, 1976,44, 250–260. (a)

    Google Scholar 

  • Rie, H. E., Rie, E. D., Stewart, S., & Ambuel, J. P. Effects of Ritalin on underachieving children: A replication.American Journal of Orthopsychiatry, 1916,46, 313–322. (b)

    Google Scholar 

  • Rosenthal, J. H. Neurophysiology of minimal cerebral dysfunctions.Academic Therapy, 1913,8, 291–294.

    Google Scholar 

  • Routh, D. K. Hyperactivity in children: Diagnosis, assessment, and treatment. In P. Magrab (Ed.),Psychological management of pediatric problems. Baltimore: University Park Press, 1978.

    Google Scholar 

  • Routh, D. K., & Roberts, R. Minimal brain dysfunction in children: Failure to find evidence for a behavioral syndrome.Psychological Reports, 1912,31, 307–314.

    Google Scholar 

  • Saletu, B., Saletu, M., & Itil, T. M. The relationships between psychopathology and evoked responses before, during, and after psychotropic drug treatment.Biological Psychiatry, 1973,6, 45–71.

    Google Scholar 

  • Saletu, B., Saletu, M., Simeon, J., Viamontes, G., & Itil, T. M. Comparative symptomatology and evoked potential studies with d-amphetamine, thioridazine, and placebo in hyperkinetic children.Biological Psychiatry, 1915,10, 253–275.

    Google Scholar 

  • Satterfield, J. H. Neurophysiologic studies with hyperactive children. In D. Cantwell (Ed.),The hyperactive child: Diagnosis and management. New York: Halsted Press, 1976.

    Google Scholar 

  • Satterfield, J. H., Atoian, G., Brashears, G. C., Burleigh, A. C., & Dawson, M. E. Electrodermal studies in minimal brain dysfunction children. In C. Conners (Ed.),Clinical use of stimulant drugs in children. Amsterdam: Excerpta Medica, 1974.

    Google Scholar 

  • Satterfield, J. H., Cantwell, D. P., Lesser, L. I., & Podosin, R. L. Physiological studies of the hyperkinetic child: I.American Journal of Psychiatry, 1972,128, 1418–1424.

    Google Scholar 

  • Satterfield, J. H., Cantwell, D. P., Saul, R. E., Lesser, L. I., & Podosin, R. L. Response to stimulant drug treatment in hyperactive children: Prediction from EEG and neurololgical findings.Journal of Autism and Childhood Schizophrenia, 1973,3, 36–48.

    Google Scholar 

  • Satterfield, J. H., Cantwell, D. P., Saul, R. E., & Yusin, A. Intelligence, academic achievement, and EEG abnormalities in hyperactive children.American Journal of Psychiatry, 1914,131, 391–395.

    Google Scholar 

  • Satterfield, J. H., & Dawson, M. E. Electrodermal correlates of hyperactivity in children.Psychophysiology, 1971,8, 191–197.

    Google Scholar 

  • Satterfield, J. H., Lesser, L. I., Saul, R. E., & Cantwell, D. P. EEG aspects of the diagnosis and treatment of minimal brain dysfunction.Annals of the New York Academy of Sciences, 1973,205, 274–282.

    Google Scholar 

  • Schain, R. J., & Reynard, C. L. Observations on effects of a central stimulant drug (methylphenidate) in children with hyperactive behavior.Pediatrics, 1975,55, 709–716.

    Google Scholar 

  • Sheer, D. E. Focused arousal and 40 Hz EEG. In R. Knights & D. Bakker (Eds.),The neuropsychology of learning disabilities. Baltimore: University Park Press, 1976.

    Google Scholar 

  • Shetty, T. Alpha rhythms in the hyperkinetic child.Nature, 1971,234, 476.

    Google Scholar 

  • Small, P., Hibi, S., & Feinberg, I. Effects of dextroamphetamine sulfate on EEG sleep patterns of hyperactive children.Archives of General Psychiatry, 1971,25, 369–380.

    Google Scholar 

  • Spring, C., Greenberg, L., Scott, J., & Hopwood, J. Electrodermal activity in hyperactive boys who are methylphenidate responders.Psychophysiology, 1974,11, 436–442.

    Google Scholar 

  • Sroufe, L. A., Sonies, B., West, W., & Wright, F. Anticipatory heart rate deceleration and reaction time in children with and without referral for learning disability.Child Development, 1973,44, 267–273.

    Google Scholar 

  • Sternbach, R. Two independent indices of activation.Electroencephalography and Clinical Neurophysiology, 1960,12, 609–611.

    Google Scholar 

  • Strauss, A., & Lehtinen, L.Psychopathology and education in the brain-injured child. New York: Grune and Stratton, 1947.

    Google Scholar 

  • Ullman, D. G., Barkley, R. A., & Brown, J. W. Behavioral symptoms of hyperkinetic children who responded to methylphenidate treatment.American Journal of Orthopsychiatry, 1918,48, 425–437.

    Google Scholar 

  • Weber, B. A., & Sulzbacher, S. I. Use of CNS stimulant medication in averaged electroencephalic audiometry with children with MBD.Journal of Learning Disabilities, 1915,8, 300–313.

    Google Scholar 

  • Wender, P. H.Minimal brain dysfunction in children. New York: Wiley, 1971.

    Google Scholar 

  • Werry, J. S. Some clinical and laboratory studies of psychotropic drugs in children: An overview. In W. Smith (Ed.),Drugs and cerebral function, Springfield, Illinois: Charles C Thomas, 1970.

    Google Scholar 

  • Whitmer, P. O.EMG biofeedback manipulation of arousal as a test of the over-arousal and under-arousal theories of childhood hyperactivity. Doctoral dissertation, University of Miami, 1977.

  • Zahn, T. P., Abate, F., Little, B. C., & Wender, P. H. Minimal brain dysfunction, stimulant drugs, and autonomic nervous system activity.Archives of General Psychiatry, 1975,32, 381–387.

    Google Scholar 

  • Zentall, S. S. Optimal stimulation as a theoretical basis of hyperactivity.American Journal of Orthopsychiatry, 1915,45, 549–563.

    Google Scholar 

  • Zentall, S. S., & Zentall, T. R. Activity and task performance of hyperactive children as a function of environmental stimulation.Journal of Consulting and Clinical Psychology, 1916,44, 693–697. (a)

    Google Scholar 

  • Zentall, S. S., & Zentall, T. R. Amphetamine's paradoxical effects may be predictable.Journal of Learning Disabilities, 1916,9, 61–62. (b)

    Google Scholar 

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Authors and Affiliations

  1. Medical College of Wisconsin and Milwaukee Children's Hospital, USA

    Russell A. Barkley

  2. Psychology Service, Wood Veterans' Administration Hospital, 53219, Wood, Wisconsin

    James E. Hastings

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  1. James E. Hastings
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The authors would like to thank James Hart, Ph.D., and Herbert Swick, M.D., for their comments on an earlier version of this manuscript.

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Hastings, J.E., Barkley, R.A. A review of psychophysiological research with hyperkinetic children. J Abnorm Child Psychol 6, 413–447 (1978). https://doi.org/10.1007/BF00926054

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