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Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

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Abstract

We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the ɛ4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

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Authors and Affiliations

  1. Department of Epidemiology & Biostatistics and the Netherlands Institute for Health Sciences, Erasmus University Medical School, PO Box 1738, NL-3000, Rotterdam, DR Rotterdam, The Netherlands

    Juliana Bronzova, Cornelia M. van Duijn & Albert Hofman

  2. The Laboratory of Molecular Pathology, University Hospital of Obstetrics and Gynaecology, Medical University, Sofia, Bulgaria

    Juliana Bronzova

  3. TNO, Institute of Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands

    Louis M. Havekes & Peter de Knijff

  4. The Neurogenetics Laboratory, Flemish Institute of Biotechnology, Born Bunge Foundation, Department of Biochemistry, University of Antwerp, Antwerpen, Belgium

    Christine Van Broeckhoven

Authors
  1. Juliana Bronzova
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  2. Cornelia M. van Duijn
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  3. Louis M. Havekes
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  4. Peter de Knijff
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  5. Christine Van Broeckhoven
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  6. Albert Hofman
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Corresponding author

Correspondence to Cornelia M. van Duijn.

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Bronzova, J., van Duijn, C.M., Havekes, L.M. et al. Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. J Neurol 243, 465–468 (1996). https://doi.org/10.1007/BF00900501

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  • DOI: https://doi.org/10.1007/BF00900501

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