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Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat

An ultrastructural study

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Summary

Peripheral nerves of the diabetic insulin-dependent BB-Wistar-rat were studied ultrastructurally. Conspicuous early changes consisted of mitochondrial accumulation of glycogen in the axons and the development of honey-combed Schwann cell-axon networks. The later stages of the diabetic syndrome showed axonal dwindling and disintegration in both myelinated and unmyelinated fibers. The present findings are compared with those of other experimental diabetic models.

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology, University of Toronto and Toronto General Hospital, M5G 1L5, Toronto, Canada

    Anders A. F. Sima

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  1. Anders A. F. Sima
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Supported in part by grants from the Canadian Diabetic Association. The Juvenile Diabetic Foundation (79B377), and the Medical Research Council of Canada (MA-7117)

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Sima, A.A.F. Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat. Acta Neuropathol 51, 223–227 (1980). https://doi.org/10.1007/BF00687389

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  • DOI: https://doi.org/10.1007/BF00687389

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