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Reactions of aromatic and heteroaromatic compounds carrying electron-acceptor substituents. 26. Acylaminomethylation of 2-acylthiophenes, 2-thiophenecarboxylic acid, and its esters

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The reaction of 2-thiophene aldehyde, 2-acetylthiophene, 2-thiophene carboxylic acid, and its methyl ester with N-(hydroxymethyl)chloroacetamide in concentrated sulfuric acid yields a mixture of 4- and 5-(N-chloroacetylamino) methyl derivatives, the former being preferred.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, 117913, Moscow

    Ya. L. Gol'dfarb, A. P. Yakubov & L. I. Belen'kii

Authors
  1. Ya. L. Gol'dfarb
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  2. A. P. Yakubov
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  3. L. I. Belen'kii
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Additional information

For Communication 25, see [1].

Deceased.

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 793–797, June, 1986.

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Gol'dfarb, Y.L., Yakubov, A.P. & Belen'kii, L.I. Reactions of aromatic and heteroaromatic compounds carrying electron-acceptor substituents. 26. Acylaminomethylation of 2-acylthiophenes, 2-thiophenecarboxylic acid, and its esters. Chem Heterocycl Compd 22, 625–629 (1986). https://doi.org/10.1007/BF00575243

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  • DOI: https://doi.org/10.1007/BF00575243

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