Abstract
Of a group of 55 thyrotoxic patients given therapeutic radio-iodine (131I), 24 were made euthyroid with carbimazole before131I: the remainder were given131I alone. Carbimazole was discontinued 5 days before131I was administered. By 3 months after131I treatment there was a greater incidence of hypothyroidism in the group given131I alone (42% vs 25%), but a lower incidence of persistent thyrotoxicosis (16% vs 46%), (P>0.05). One year after treatment a similar proportion of each group had persistent thyrotoxicosis (21% vs 23%), but there remained a lower incidence of hypothyroidism in the group pretreated with carbimazole (25% vs 45%). It is suggested that pretreatment with carbimazole reduces the degree of radiation induced thyroid damage.
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Connell, J.M.C., Hilditch, T.E., McCruden, D.C. et al. Effect of pretreatment with carbimazole on early outcome following radio-iodine (131I) therapy. Eur J Nucl Med 9, 464–466 (1984). https://doi.org/10.1007/BF00563170
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DOI: https://doi.org/10.1007/BF00563170