Summary
This paper reports a study of the bronchodilator effects of doses of the beta2 agonist fenoterol and the muscarinic blocker ipratropium suitable for administering in combination as a standard dose of two discharges from a single metereddose pressurised aerosol. In 12 middle-aged bronchitics who had already been shown to respond to both types of drug the combination was almost always a little (6% on average) more effective than either drug singly. It is possible that an equal or better effect could have been obtained if fenoterol or perhaps ipratropium had been given alone in an individually determined maximally effective dose.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bäcklund, L., Fagerberg, E.: Ventilatory capacity after bronchodilation with a new beta-sympathomimetic substance. Scand. J. Respir. Dis.49, 284–290 (1968)
McLean, A. E. M.: Chlorofluorocarbons, in the can, in man, and in the atmosphere. Br. J. clin. Pharmacol.4, 663–666 (1977)
Hathirat, S., Renzetti, A. D., Jr., Mitchell, M.: Intrapulmonary gas distribution. Am. Rev. Respir. Dis.102, 750–759 (1970)
Medical Research Council Report, Definition and classification of chronic bronchitis. Lancet1965/vnI 124–126
Poppius, H., Salorinne, Y.: Comparative trial of a new anti-cholinergic bronchodilator, Sch 1000 and salbutamol in chronic bronchitis. Br. med. J.1973/IV, 134–136
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Addis, G.J., Barclay, J. & Chang, E.M. Assessment of a combination of doses of fenoterol and ipratropium suitable for a single metered-dose aerosol. Eur J Clin Pharmacol 16, 97–100 (1979). https://doi.org/10.1007/BF00563114
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00563114