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Clinical trial of a new beta-receptor blocking agent, tolamolol, in angina pectoris

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Summary

The effect of a new beta-adrenergic blocking agent tolamolol, has been examined in a double-blind cross-over study in 18 patients suffering from angina pectoris. After a run-in period of four weeks, during which the patients received placebo, there were two periods each of four weeks when either tolamolol (100–200 mg three times daily) or placebo was given. The patients underwent a standardized exercise test at the end of each treatment period. Tolamolol caused a significant decrease in anginal attacks and the patients' consumption of nitroglycerin was reduced compared both to the run-in and placebo periods. There was an increase in the capacity for physical work, but it was significant only in comparison with the run-in period. Heart rate and blood pressure were significantly reduced at rest and at work during treatment with tolamolol. There were no side effects of treatment with tolamolol.

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Authors and Affiliations

  1. Departments of Clinical Physiology and Cardiology, Lasarettet, Lund, Sweden

    I. Nordenfelt, L. Olsson & S. Persson

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  1. I. Nordenfelt
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  2. L. Olsson
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  3. S. Persson
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Nordenfelt, I., Olsson, L. & Persson, S. Clinical trial of a new beta-receptor blocking agent, tolamolol, in angina pectoris. Eur J Clin Pharmacol 7, 157–162 (1974). https://doi.org/10.1007/BF00560375

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  • DOI: https://doi.org/10.1007/BF00560375

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