Summary
The pharmacokinetics of atenolol with and without the co-administration of chlorthalidone were studied in five hypertensive subjects. Concomitant administration of chlorthalidone appears to have little if any effect on the pharmacokinetics of atenolol during treatment for 7 days. The atenolol elimination half-lives were 6.7±1.1 and 6.3±0.9 h, respectively, with and without chlorthalidone. Two healthy volunteers also received a single 50 mg oral dose of chlorthalidone. Their blood profiles and pharmacokinetics were similar to those observed in hypertensive subjects, but a statistically significant difference (p<0.01) was found between the urinary excretion half-lives of chlorthalidone. This difference may be because chronic administration of the drug caused saturation of red cell binding.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amery A, De Plaen JF, Lijen P, McAinsh J, Reybrouck T (1977) Relationship between blood level of atenolol and pharmacologic effect. Clin Pharmacol Ther 21: 691–699
Brown HC, Carruthers SG, Johnston GD, Kelly JG, McAinsh J, McDevitt DG, Shanks RG (1976) Clinical pharmacologic observations on atenolol, a beta adrenoceptor blocker. Clin Pharmacol Ther 20: 524–534
Collste P, Garle M, Rawlins MD, Sjoqvist F (1976) Interindividual differences in chlorthalidone concentration in plasma and red cells after single and multiple doses. Eur J Clin Pharmacol 9: 319–325
Conway FJ, Fitzgerald JD, McAinsh J, Rowlands DJ, Simpson WT (1976) Human pharmacokinetic and pharmacodynamic studies on atenolol (ICI 66,082) a new cardioselective β-adrenoceptor blocking drug. Br J Clin Pharmacol 3: 267–272
Dieterle W, Wagner J, Faigle JW (1976) Binding of chlorthalidone (Hygroton®) to blood components in man. Eur J Clin Pharmacol 10: 37–42
Ervik M, Gustavii K (1974) Application of the extractive alkylation technique to the gas chromatographic determination of chlorthalidone in plasma in nanogram quantities. Anal Chem 46: 39–42
Fitzgerald JD, Ruffin R, Smedstad KG, Roberts R, McAinsh J (1978) Studies in the pharmacokinetics and pharmacodynamics of atenolol in man. Eur J Clin Pharmacol 13: 81–89
McAinsh J (1977) Clinical pharmacokinetics of atenolol. Postgrad Med J 53: (Suppl 3) 74–78
Reeves PR, McAinsh J, McIntosh DAD, Winrow MJ (1978) Metabolism of atenolol in man. Xenobiotica 8: 313–320
Sassard J, Pozet N, McAinsh J, Legheand J, Zech P (1977) Pharmacokinetics of atenolol in patients with renal impairment. Eur J Clin Pharmacol 12: 175–180
Scales B, Copsey PB (1975) The gas chromatographic determination of atenolol in biological samples. J Pharm Pharmacol 27: 430–433
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Riva, E., Farina, P.L., Sega, R. et al. Pharmacokinetics of atenolol in hypertensive subjects with and without co-administration of chlorthalidone. Eur J Clin Pharmacol 17, 333–337 (1980). https://doi.org/10.1007/BF00558445
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00558445