Abstract
Multiple regression analysis and discriminant function analyses were applied to the question of prediction of therapeutic success or failure to clozapine therapy, using a non-biological predictor pool of 46 items. This effort was not successful, accounting for less than 25% of outcome variance under optimal conditions. However, it does appear that while clozapine efficacy in treatment-resistant schizophrenic patients in general is superior to such neuroleptics as chlorpromazine or haloperidol, the “paranoid” subgroup appears to benifit most.
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References
Kane J, Honigfeld G et al. (1988) Clozapine for the treatment-resistant schizophrenic. Arch Gen Psychiatry 45:789–796
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Honigfeld, G., Patin, J. Predictors of response to clozapine therapy. Psychopharmacology 99 (Suppl 1), S64–S67 (1989). https://doi.org/10.1007/BF00442562
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DOI: https://doi.org/10.1007/BF00442562