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Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F

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Abstract

The present work examined some central nervous actions of prostaglandin D2 (PGD2), which is the most prevalent prostaglandin in rodentorain. The effects of PGD2 were compared with those of PGE2 and PGF. The prostaglandins were administered intracerebroventricularly (ICV) to conscious rats using the method of Herman (1970). All three prostaglandins studied produced depressive behavioral effects, causing obvious sedation at doses of 2.0 μg and 20.0 μg ICV. PGD2 and PGE2 significantly reduced spontaneous motor activity at doses of 2.0 μg and 20.0 μg ICV. PGF was less effective; only 20.0 μg significantly inhibited motor activity. At a dose of 20.0 μg ICV all three compounds were shown to block convulsions induced by pentylenetetrazol. PGD2, the most effective prostaglandin in this respect, was still slightly anticonvulsive at a dose of 2.0 μg ICV. PGF hat the weakest anticonvulsive potency. PGE2 and PGF (2.0 μg and 20.0 μg ICV) caused a marked hypertensive effect, whereas PGD2 at the same dose levels only produced a small increase in blood pressure. PGE2 and PGF (2.0 μg and 20.0 μg) also exerted marked pyrogenic actions. The effects of PGD2 on body temperature were variable. When given at a dose of 20.0 μg ICV, it caused slight hyperthermia whereas a lower dose (2.0 μg ICV) induced a moderate fall in body temperature. These findings suggest a relationship between the actions of the different prostaglandins on blood pressure and body temperature.

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A preliminary report was given at the Spring Meeting of the Deutsche Pharmakologische Gesellschaft, March 1983 (Förstermann and Heldt, 1983)

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Förstermann, U., Heldt, R. & Hertting, G. Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F . Psychopharmacology 80, 365–370 (1983). https://doi.org/10.1007/BF00432122

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  • DOI: https://doi.org/10.1007/BF00432122

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