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Acute effects of alcohol on saccadic eye movements

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Abstract

Four components of 20° horizontal saccadic eye movements, i.e., latency, mean and maximum velocities, and duration were measured in 16 students under the influence of alcohol and also in a control situation. The experimental procedures were standarized and automated as much as possible. Latency (simple eye reaction time) was not influenced by alcohol in blood concentrations of 0.056–0.116%. Mean and maximum eye velocities decreased by about 9% and duration of saccades increased by 11%. The maximum changes occurred 90–120 min after the start of alcohol ingestion. The changes in velocities and durations correlated more closely with feelings of intoxication than with blood alcohol concentrations. There were great intra- and intersubject variations in reactions to alcohol. The close resemblance between the effects of certain psychotropic drugs, alcohol, fatigue, and decreased attention on eye movement control suggest that all these may act upon the same nervous structures in the brain steim.

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References

  • Aschan, G.: Different types of alcohol nystagmus. Acta Otolaryngol. (Stokh) 140, 69–78 (1958)

    Google Scholar 

  • Aschan, G., Bergstedt, M., Goldberg, L., Laurell, L.: Positional nystagmus in man during and after alcohol intoxication. Q. J. Stud. Alc. 17, 381–405 (1956)

    Google Scholar 

  • Bahill, H. T., Stark, L.: Overlapping saccades and glissades are produced by fatigue in the saccadic eye movement system. Exp. Neurol. 48, 95–106 (1975)

    Google Scholar 

  • Baloh, R. W., Konrad, H. R., Sills, A. W., Honrubia, V.: The saccade velocity test. Neurology (Minneap.) 25, 1071–1076 (1975a)

    Google Scholar 

  • Baloh, R. W., Sills, A. W., Kumley, W. E., Honrubia, V.: Quantitative measurement of saccade amplitude, duration and velocity. Neurology (Minneap.) 25, 1065–1070 (1975b)

    Google Scholar 

  • Bender, M. B., Shanzer, S.: Oculomotor pathways defined by electrical stimulation and lesions in the brainstem of monkey. In: The oculomotor system. M. B. Bender, ed., pp. 81–140. New York: Harper and Row 1964

    Google Scholar 

  • Boghen, D., Troost, B. T., Daroff, R. B., Dell'osso, L. F., Birkett, J. E.: Velocity characteristics of normal human saccades. Invest. Ophthalmol. Visual Sci. 13, 619–623 (1974)

    Google Scholar 

  • Crommelinck, M., Roucoux, A.: Characteristics of cat's eye saccades in different states of alertness. Brain Res. 103, 479–480 (1976)

    Google Scholar 

  • Dichgans, J., Nauck, B., Wolpert, E.: The influence of attention, vigilance and stimulus area on optokinetic and vestibular nystagmus and voluntary saccades. In: Oculomotor system and brain functions. V. Zikmund, ed., pp. 280–294. London: Butterworths 1973

    Google Scholar 

  • Franck, M. C., Kuhlo, W.: Die Wirkung des Alkohols auf die raschen Blickzielbewegungen (Saccade) beim Menschen. Arch. Psychiatr. Nervenkr. 213, 238–245 (1970)

    Google Scholar 

  • Franks, H. M., Hensley, W. J., Starmer, G. A., Teo, R. K. C.: The relationship between alcohol dosage and performance decrement in humans. J. Stud. Alc. 37, 284–297 (1976)

    Google Scholar 

  • Guldberg, L.: Behavioral and physiological effects of alcohol on man. Psychosom. Med. 28, 570–595 (1966)

    Google Scholar 

  • Guedry, F. E., Jr., Gilson, R. D., Schroeder, D. J., Collins, W. E.: Some effects of alcohol on various aspects of oculomotor control. Aerosp. Med. 46, 1008–1013 (1975)

    Google Scholar 

  • Hobson, J. A., McCarley, R. W., Freedman, R., Pivik, R. T.: Time course of discharge rate changes by cat pontine brain stem neurons during sleep cycle. J. Neurophysiol. 37, 1297–1309 (1974)

    Google Scholar 

  • Hoyt, W. F., Daroff, R. B.: Supranuclear disorders of ocular control systems in man. In: The control of eye movements. P. Bach-y-Rita, C. C. Collins, eds. New York, London: Academic Press 1971

    Google Scholar 

  • Kleinknecht, R. A., Donaldson, D.: A review of the effects of diazepam on cognitive and psychomotor performance. J. Nerv. Ment. Dis. 161, 399–411 (1975)

    Google Scholar 

  • Kris, C.: Electro-oculography. In: Medical Physics, Vol. III, Glasser, ed., pp. 692–700, Chicago Year Book 1960

  • Lehtinen, I., Lang, H., Keskinen, E.: The effects of ethanol on the human ocular motility. In: Fifth Scandinavian Meeting on Physiology and Behaviour, p. 25. Helsingin yliopiston monistuspalvelu. Helsinki 1977

  • Lehtinen, I., Lang, H., Keskinen, E.: Alcohol-induced changes in human electroencephalogram. Acta Physiol. Scand. 440, 104 (1976)

    Google Scholar 

  • Niemi, P., Keskinen, E., Lang, H., Lehtinen, I.: Reaction process and alcohol. In: Fifth Scandinavian Meeting on Physiology and Behaviour, p. 31. Helsingin yliopiston monistuspalvelu. Helsinki 1977

  • Pivik, R. T., McCarley, R. W., Hobson, J. A.: Eye movement-associated discharge in brain stem neurons during desynchronized sleep. Brain Res. 121, 59–76 (1977)

    Google Scholar 

  • Rashbass, C.: The relationship between saccadic and smooth tracking eye movements. J. Physiol. (Lond.) 159, 326–338 (1961)

    Google Scholar 

  • Schubert, K.: Der Vestibularis in der verkehrsmedizin. In: Handbuch der Verkehrsmedizin, K. Wagner, H. J. Wagner, eds., pp. 553–568. Berlin, Heidelberg, New York: Springer 1968

    Google Scholar 

  • Stern, J. A., Bremer, D. A., McClure, J.: Analysis of eye movements and blinks during reading: Effects of Valium. Psychopharmacologia (Berl.) 40, 171–175 (1974)

    Google Scholar 

  • Wallgren, H., Barry, H. III: Actions of Alcohol (2 Vols). Amsterdam: Elsevier 1970

    Google Scholar 

  • Wilkinson, I. M. S.: The influence of drugs and alcohol upon human eye movement. Proc. R. Soc. Med. 69, 479–480 (1976)

    Google Scholar 

  • Wilkinson, I. M. S., Kime, R., Purnell, M.: Alcohol and human eye movement. Brain 97, 785–792 (1974)

    Google Scholar 

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Lehtinen, I., Lang, A.H., Jäntti, V. et al. Acute effects of alcohol on saccadic eye movements. Psychopharmacology 63, 17–23 (1979). https://doi.org/10.1007/BF00426915

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