Abstract
Daily administration of ethanol in a liquid diet or by intubation were both effective in producing tolerance to the hypothermic effects of ethanol. When p-chlorophenylalanine (p-CPA) was administered in a dose previously demonstrated to maintain extensive brain serotonin (5-HT) depletion, the temperature-lowering effects of ethanol were less pronounced than in corresponding controls. The analysis of the effect of p-CPA on tolerance development took into account both initial body temperature and the degree of hypothermia. This study extends our findings with respect to the inhibitory effect of p-CPA on the development of tolerance to the motor-impairing effects of ethanol, and suggests that 5-HT may have a role in tolerance development to ethanol.
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Frankel, D., Khanna, J. M., LeBlanc, A. E., Kalant, H.: Effect of p-chlorophenylalanine on the acquisition of tolerance to ethanol and pentobarbital. Psychopharmacologia (Berl.) 44, 247–252 (1975)
Frankel, D., Khanna, J. M., Kalant, H., LeBlanc, A. E.: Effect of acute and chronic ethanol administration on serotonin turnover in rat brain. Psychopharmacologia (Berl.) 37, 91–100 (1974)
Freund, G.: Hypothermia after acute ethanol and benzyl alcohol administration. Life Sci. 13, 345–349 (1973)
Gibbins, R. J., Kalant, H., LeBlanc, A. E.: A technique for accurate measurement of moderate degrees of alcohol intoxication in small animals. J. Pharmacol. Exp. Ther. 159, 236–242 (1968)
Koe, B. K.: Tryptophane hydroxylase inhibitors. Fed. Proc. 30, 886–896 (1971)
LeBlanc, A. E., Kalant, H., Gibbins, R. J., Berman, N. D.: Acquisition and loss of tolerance to ethanol by the rat. J. Pharmacol. Exp. Ther. 168, 244–250 (1969)
Pearson, J. A., Wills, L., MacDonald, J. F.: The effect of p-CPA and lesions of the dorsal raphe nucleus on habituation of the flexor withdrawal reflex. Brain Res. 77, 515–520 (1974)
Pohorecky, L. A., Brick, J., Sun, J. Y.: Serotonergic involvement in the effect of ethanol on body temperature in rats. J. Pharm. Pharmacol. 28, 157–159 (1976)
Ritzmann, R. F., Tabakoff, B.: Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence. J. Pharmacol. Exp. Ther. 199, 158–170 (1976)
Sanders-Bush, E., Gallager, D. A., Sulser, F.: On the mechanism of brain 5-hydroxytryptamine depletion by p-chloroamphetamine and related drugs and the specificity of their action. In: Serotonin: new vistas. Histochemistry and pharmacology, E. Costa, G. L. Gessa, and M. Sandler, eds., pp. 185–194. Advances in biochemical psychopharmacology, vol. 10. New York: Raven Press 1974
Tenen, S. S.: The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat. Psychopharmacologia (Berl.) 10, 204–219 (1967)
Tilson, H. A., Rech, R. H.: The effects of p-chlorophenylalanine on morphine analgesia, tolerance and dependence development in two strains of rats. Psychopharmacologia (Berl.) 35, 45–60 (1974)
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Frankel, D., Khanna, J.M., Kalant, H. et al. Effect of p-chlorophenylalanine on the acquisition of tolerance to the hypothermic effects of ethanol. Psychopharmacology 57, 239–242 (1978). https://doi.org/10.1007/BF00426744
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DOI: https://doi.org/10.1007/BF00426744