Abstract
The types and prevalence of haematological abnormalities occurring in FIV infected cats were determined. In addition, the role of FIV infection per se in influencing haematological values was examined by analysing results between infected and non-infected cats which had been allocated to similar clinical disease groups. FIV-positive cats were grouped as asymptomatic carriers (AC), cats with AIDS-related complex (ARC) or AIDS. FIV-negative cats were placed into matched groups using the same criteria and designated as healthy, ‘ARC’ or ‘AIDS’. Healthy FIV-negative cats also formed the reference ranges for peripheral blood and bone marrow. Anaemia was no more frequent in sick (‘ARC’ and ‘AIDS’) FIV-positive cats than sick (‘ARC’ and ‘AIDS’) FIV-negative cats. However, it was observed more frequently in FIV-positive cats than FIV-negative cats in the absence of concurrent disease, suggesting a direct effect of FIV infection. Bone marrow was affected by FIV infection; as evidenced by anaemic FIV-positive cats having proportionally less Type I reticulocytes than anaemic FIV-negative cats. In addition, FIV-positive cats demonstrated proportionally fewer mature erythroid cells in their marrow. This implied that FIV may cause a decreased life span or maturation arrest of the erythroid cell line. Lymphopenia and eosinopenia were seen more frequently in AC FIV-positive cats than healthy FIV-negative cats, suggesting the direct involvement of FIV. Thus, although FIV infection affected some haematological findings in AC cats, it appeared that haematological abnormalities in sick FIV-positive cats may be due as much to the disease state as to the virus specifically. Apart from the subjective assessment that bone marrow of FIV-positive cats appeared hypercellular, there were no pathognomonic features for FIV infection.
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References
Centers for Disease Control (1992) 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 41:1–19
Cramer DV, Lewis RM (1972) Reticulocyte response in the cat. J Am Vet Med Assoc 160:61–67
Delacrétaz F, Perey L, Schmidt P-M et al. (1987) Histopathology of bone marrow in human immunodeficiency virus infection. Virchows Arch A 411:543–551
Duncan JR, Prasse KW (1986) Leucocytes. In: Veterinary laboratory medicine. Iowa State University Press, Ames, pp 31–60
Fan LC, Dorner JL, Hoffmann WE (1978) Reticulocyte response and maturation in experimental acute blood loss anemia in the cat. J Am Anim Hosp Assoc 14:219–224
Farver TB (1989) Concepts of normality in clinical biochemistry. In: Kaneko JJ (ed) Clinical biochemistry of domestic animals. Academic Press, San Diego, pp 1–20
Fleming EJ, McCaw DL, Smith JA et al. (1991) Clinical, hematologic, and survival data from cats infected with feline immunodeficiency virus: 42 cases (1983–1988). J Am Vet Med Assoc 199:913–916
Giorgi JV, Hultin LE (1990) Lymphocyte subset alterations and immunophenotyping by flow cytometry in HIV disease. Clin Immunol 10:55–61
Harbour DA, Williams PD, Gruffydd-Jones TJ et al. (1988) Isolation of a T-lymphotropic lentivirus from a persistently leucopenic domestic cat. Vet Rec 122:84–86
Hillman RS, Finch CA (1969) The misused reticulocyte. Br J Haematol 17:313
Hopper CD, Sparkes AH, Gruffydd-Jones TJ et al. (1989) Clinical and laboratory findings in cats infected with feline immunodeficiency virus. Vet Rec 125:341–346
Hosie MJ, Robertson C, Jarrett O (1989) Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Vet Rec 128:293–297
Jain NC (1986a) Hematology of the cat. In: Schalm's Veterinary Hematology. Lea & Febiger, Philadelphia, pp 126–139
Jain NC (1986b) Clinical and laboratory evaluation of anemias and polycythemias. In: Schalm's veterinary hematology. Lea & Febiger, Philadelphia, pp 563–576
Jain NC (1986c) Examination of the blood and bone marrow. In: Schalm's veterinary hematology. Lea & Febiger, Philadelphia, pp 1–19
Jain NC (1993) The lymphocytes and plasma cells. In: Essentials of veterinary hematology. Lea & Febiger, Philadelphia, pp 278–294
Mandell CP, Sparger EE, Pedersen NC et al. (1992) Long-term haematological changes in cats experimentally infected with feline immunodeficiency virus (FIV). Comp Haematol Int 2:8–17
Perkocha LA, Rodgers GM (1988) Hematological aspects of human immunodeficiency virus infection: laboratory and clinical considerations. Am J Hematol 129:94–105
Reinacher M, Holznagel E (1991): Post mortem diagnosis of spontaneous FIV infection. Proceedings of the First International Conference of Feline Immunodeficiency Virus Researchers, University of California, Davis, CA, 4-7 Sept, p2
Schneider DR, Picker LJ (1985) Myelodysplasia in the acquired immunodeficiency syndrome. Am J Clin Pathol 84:144–152
Shaw SE, Robertson ID, Robinson WF et al. (1990) Feline immunodeficiency virus: disease associations. Aust Vet Pract 20:194–198
Shelton GH, Abkowitz JL, Linenberger ML et al. (1989) Chronic leukopenia associated with feline immunodeficiency virus infection in a cat. J Am Vet Med Assoc 194:253–255
Shelton GH, Linenberger ML, Grant CK et al. (1990) Hematologic manifestations of feline immunodeficiency virus infection. Blood 76:1104–1109
Sparkes AH, Hopper CD, Millard WG et al. (1993) Feline immunodeficiency virus infection. Clinicopathologic findings in 90 naturally occurring cases. J Vet Int Med 7:85–90
Spivak JL, Bender BS, Quinn TC (1984) Hematologic abnormalities in the acquired immune deficiency syndrome. Am J Med 77:224–228
Thomas JB, Robinson WF (1994) Anaemia in Western Australian cats. Aust Vet Pract 24:210–217
Thomas JB, Robinson WF, Chadwick BJ et al. (1993) Leukogram and biochemical abnormalities in naturally occurring FIV infection. J Am Anim Hosp Assoc 29:272–278
Treacy M, Lai L, Costello C et al. (1987) Peripheral blood and bone marrow abnormalities in patients with HIV related disease. Br J Haematol 65:289–294
Walker C, Canfield PJ, Love DN (1994) Analysis of leucocytes and lymphocyte subsets for different clinical stages of naturally-acquired feline immunodeficiency virus infection. Vet Immunol Immunopathol 44:1–12
Walker C, Canfield PJ, Love DN et al. (1996) A longitudinal study of lymphocyte subsets in a cohort of cats naturally infected with feline immunodeficiency virus. Aust Vet J 73:218–224
Yamamoto JK, Sparger E, Ho EW et al. (1988) Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. Am J Vet Res 49:1246–1258
Yamamoto JK, Hansen H, Ho EW et al. (1989) Epidemiological and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. J Am Vet Med Assoc 194:213–220
Zon LI, Arkin C, Groopman JE (1987) Haematologic manifestations of the human immune deficiency virus (HIV). Brit J Haematol 66:251–256
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Walker, C., Canfield, P. Haematological findings in cats naturally infected with feline immunodeficiency virus. Comparative Haematology International 6, 77–85 (1996). https://doi.org/10.1007/BF00426046
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DOI: https://doi.org/10.1007/BF00426046