Abstract
The effects of acute and chronic chlorpromazine treatment on psychomotor stimulant self-administration behavior in the Rhesus monkey were determined. Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine, pipradrol, phenmetrazine, d-amphetamine and methylphenidate. The basis of this effect was thought to either be due to an antagonism of the reinforcing effect of these compounds or an antagonism of those actions of the psychomotor stimulants which may function in limiting their self-administration.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Benesova, O., Trinerova, I.: The effects of psychotropic drugs on the cholinergic and adrenergic system. Int. J. Neuropharmacol. 3, 473–478 (1964).
Deneau, G., Inoki, R.: Nicotine self-administration in monkeys. Ann. N.Y. Acad. Sci. 142, 277–279 (1967).
Espelin, D., Done, A.: Amphetamine poisoning. New Eng. J. Med. 278, 1361–1365 (1968).
Maickel, R.: Diverse central effects of chlorpromazine. Int. J. Neuropharmacol. 7, 23–27 (1968).
Pickens, R., Harris, W.: Self-administration of d-amphetamine by rats. Psychopharmacologia (Berl.) 12, 158–163 (1968).
—, Meisch, R., McGuire, L.: Methamphetamine reinforcement in rats. Psychon. Sci. 8, 371–372 (1967).
—, Thompson, T.: Cocaine-reinforced behavior in rats: Effects of reinforcement magnitude and fixed ratio size. J. Pharmacol. exp. Ther. 161, 122–129 (1968).
Reid, A.: Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients. Med. J. Aust. 25, 187–188 (1964).
Stein, L., Ray, O.: Brain stimulation reward “thresholds” self-determined in rats. Psychopharmacologia (Berl.) 1, 251–256 (1960).
Wilson, M. C., Hitomi, M., Schuster, C. R.: Psychomotor stimulant self-administration as a function of dosage per injection in the Rhesus monkey. Psychopharmacologia (Berl.) (submitted for publication).
Woods, J., Schuster, C. R.: Reinforcement properties of morphine, cocaine and SPA as a function of unit dose. Int. J. Addict. 3, 231–237 (1968).
Yanagita, T., Deneau, G., Seevers, M.: Evaluation of pharmacological agents in the monkey by long-term intravenous self or programmed administration. Excerpta Med. Int. Congr. Series 87, 453–457 (1965).
Author information
Authors and Affiliations
Additional information
This study was supported by NIMH Grant No. 5r-10MH-12084 and by NIMH Grant No. MH-18245-01.
Rights and permissions
About this article
Cite this article
Wilson, M.C., Schuster, C.R. The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey. Psychopharmacologia 26, 115–126 (1972). https://doi.org/10.1007/BF00422098
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00422098