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Biochemical changes in a 100 km run: Proteins in serum and urine

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Summary

Eleven male subjects took part in a 100 km running competition. Alterations in the total plasma protein and in ten individual plasma protein concentrations in blood and urine were measured prior to the run, immediately after and after 1 day of recovery. Five individual proteins showed a 7–10%, and lysozyme a 40%, increase in the plasma after the run. On the contrary, the haptoglobin concentration fell to 40% of its pre-race level. None of these variations were correlated with the plasma volume change. The present data showed a moderate hemolysis, as evidenced by plasma lysozyme and hemoglobin-haptoglobin binding. The urinary excretion of plasma proteins was slightly increased, especially albumin and α 1-acid-glycoprotein. The renal clearance of plasma proteins revealed that the 100 km run induced a moderate increase of glomerular permeability without any significant change in the tubular reabsorption process.

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Authors and Affiliations

  1. Chimie Physiologique, Institut Supérieur d'Education Physique et de Kinésithérapie, Université Libre de Bruxelles, 28, Avenue Paul Héger, B-1050, Bruxelles, Belgium

    J. R. Poortmans

  2. Abteilung Sport- und Leistungsmedizin, Medizinische UniversitÄtsklinik, D-7800, Freiburg, Federal Republic of Germany

    G. Haralambie

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  1. J. R. Poortmans
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Poortmans, J.R., Haralambie, G. Biochemical changes in a 100 km run: Proteins in serum and urine. Europ. J. Appl. Physiol. 40, 245–254 (1979). https://doi.org/10.1007/BF00421516

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