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Conservation of HLA class I private epitopes in macaques

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Abstract

Fifty mouse monoclonal antibodies (mAb) specific for HLA class I epitopes were compared for their reactivity against two closely related nonhuman primate species, pigtailed macaques (Macaca nemestrina, Mn) and longtailed macaques (M. fascicularis, Mfl), which diverged from the hominoids 23–40 million years ago. An analysis of Nei's genetic identity (I) and distance (D) based on reactivity of all class I-specific mAb showed, as expected, that the macaques are more closely related to each other (1=0.959) than to man (I=0.782 for Mn and 0.859 for Mfl). However, there were clear differences in genetic similarity with respect to certain epitopes. Macaques were most different from each other and from man in expression of heterologous epitopes recognized by the mouse that are not polymorphic among humans. In contrast, the most polymorphic epitopes unique to single HLA alleles, so-called private epitopes, were present in all the species, and neither macaque species could be distinguished from humans, suggesting that certain class I private epitopes may be highly conserved in evolution.[/p]

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Abbreviations

D:

Nei's index of genetic distance

I:

Nei's index of genetic identity

mAb:

monoclonal antibodies

Mfl:

Macaca fascicularis

MHC:

major histocompatibility complex

Mn:

Macaca nemestrina

PF:

phenotypic frequency

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Authors and Affiliations

  1. Departments of Microbiology and Immunology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA

    Eugene R. Heise

  2. Puget Sound Blood Center, Fred Hutchinson Cancer Research Center, and Department of Medicine, University of Washington, Seattle, Washington, USA

    John A. Hansen

  3. Department of Microbiology, University of Washington, Seattle, Washington, USA

    Edward A. Clark

  4. Regional Primate Research Center SJ-50, University of Washington, 98195, Seattle, WA, USA

    Lakshmi K. Gaur & Edward A. Clark

Authors
  1. Lakshmi K. Gaur
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  2. Eugene R. Heise
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  3. John A. Hansen
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  4. Edward A. Clark
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Gaur, L.K., Heise, E.R., Hansen, J.A. et al. Conservation of HLA class I private epitopes in macaques. Immunogenetics 27, 356–362 (1988). https://doi.org/10.1007/BF00395131

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  • DOI: https://doi.org/10.1007/BF00395131

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