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Mutator genes in different species

  • I. Point Mutations
  • 2. Mutator Genes and Mutation Mechanisms
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References

Prokaryotes

  • Ahmed, S. I., Kaplan, R. W.: Unterschiedliche Typenspektren der spontanen und hitzeinduzierten Auxotrophiemutationen bei Serratia marcescens CV/rc3 und Escherichia coli Harvard. Arch. Mikrobiol. 48, 268 (1964).

    Google Scholar 

  • Berg, C.: Auxotroph accumulation in deoxyribonucleic acid polymerase-less strains of Escherichia coli K-12. J. Bacteriol. 106 797 (1971).

    Google Scholar 

  • Böhme, H.: Genetic instability of an UV-sensitive mutant of Proteus mirabilis. Biochem. biophys. Res. Commun. 28, 191 (1967).

    Google Scholar 

  • Boram, W., Abelson, J.: Bacteriophage Mu integration: On the mechanism of Mu-induced mutations. J. molec. Biol. 62, 171 (1971).

    Google Scholar 

  • Bresler, S., Mosevitsky, M., Vyacheslavov, L.: Complete mutagenesis in a bacterial population induced by thymine starvation on solid media. Nature (Lond.) 225, 764 (1970).

    Google Scholar 

  • Cleaver, J. E.: DNA repair and radiation sensitivity in human cells (xeroderma pigmentosum). Int. J. Radiat. Biol. 18, 557 (1970).

    Google Scholar 

  • Coughlin, C. A., Adelberg, E. A.: Bacterial mutation induced by thymine starvation. Nature (Lond.) 178, 531–532 (1956).

    Google Scholar 

  • Coukell, M. B., Yanofsky, C.: Increased frequency of deletions in DNA polymerase mutants of Escherichia coli. Nature (Lond.) 228, 633 (1970).

    Google Scholar 

  • Cox, E. C.: Mutator gene action and the replication of bacteriophage DNA. J. molec. Biol. 50, 129–135 (1970).

    Google Scholar 

  • Cox, E. C., Yanofsky, C.: Mutator gene studies in Escherichia coli. J. Bact. 100, 390–397 (1969).

    Google Scholar 

  • Dawson, G. W. P.: Controlling episomes. Genetics Today 1, 420 (1964).

    Google Scholar 

  • De Lucia, P., Cairns, Y.: Isolation of an E.coli strain with a mutation affecting DNA polymerase. Nature (Lond.) 224, 1164 (1969).

    Google Scholar 

  • Demerec, M.: Frequency of spontaneous mutations in certain stocks of Drosophila melanogaster. Genetics 22, 469 (1937).

    Google Scholar 

  • Demerec, M., Hanson, J.: Mutagenic action of manganous chloride. Cold Spr. Harb. Symp. quant. Biol. 16, 215–227 (1951).

    Google Scholar 

  • Demerec, M., Lahr, E. L., Miyake, T., Galehran, I., Balbinder, E., Baric, S., Hashimoto, K., Glanville, E. V., Gross, J. D.: Bacterial genetics. Carnegie Inst. Wash. Yearbook 370, 390–406 (1957).

    Google Scholar 

  • De Serres, F. J.: Mutability of UV-sensitive strains of Neurospora crassa. Genetics 68, s14 (1971)

  • de Waard, A., Paul, A. V., Lehman, I. R.: The structural gene for deoxyribonucleic acid polymerase in bacteriophage T4 and T5. Proc. nat. Acad. Sci. (Wash.) 54, 1241–1248 (1965).

    Google Scholar 

  • Drake, J. W.: The molecular basis of mutation. San Francisco-London-Cambridge-Amsterdam: Holden-Day 1970.

    Google Scholar 

  • Drake, J. W., Allen, E. F.: Antimutagenic DNA polymerase of bacteriophage T4. Cold Spr. Harb.-Symp. quant. Biol. 33, 339–344 (1968).

    Google Scholar 

  • Drake, J. W., Allen, E. F., Forsberg, S. A., Preparata, R. M., Greening, E. O.: The genetic control of mutation rates in bacteriophage T4. Nature (Lond.) 221, 1128–1132 (1969).

    Google Scholar 

  • Freese, E. B., Freese, E.: On the specificity of DNA polymerase. Proc. nat. Acad. Sci. (Wash.) 57, 650–657 (1967).

    Google Scholar 

  • Gass, K. B., Hill, T. C., Goulian, M., Strauss, B. S., Cozzarelli, N. R.: Altered deoxyribonucleic acid polymerase activity in a methyl methanesulphonate-sensitive mutant of Bacillus subtilis. J. Bact. 108, 364 (1971).

    Google Scholar 

  • Goldstein, A., Smoot, J. S.: A strain of Escherichia coli with an unusually high rate of auxotrophic mutation. J. Bact. 70, 588–595 (1955).

    Google Scholar 

  • Gross, J. D., Karamata, D., Hempstead, P. G.: Temperature-sensitive mutants of B. subtilis defective in DNA synthesis. Cold Spr. Harb. Symp. quant. Biol. 33, 307–312 (1968).

    Google Scholar 

  • Gundersen, W. B.: New type of streptomycin resistance resulting from action of the episome-like mutator factor in Escherichia coli. J. Bact. 86, 510 (1963).

    Google Scholar 

  • Gundersen, W. B., Jyssum, K., Lie, S.: Genetic instability with episome mediated transfer in Escherichia coli. J. Bact. 83, 616 (1962).

    Google Scholar 

  • Haefner, K.: Spontaneous lethal sectoring, a further feather feature of Escherichia coli strains deficient in the function of rec and uvr genes. J. Bact. 96, 652–659 (1968).

    Google Scholar 

  • Hall, Z. W., Lehman, I. R.: An in vitro transversion by a mutationally altered T4-induced DNA polymerase. J. molec. Biol. 36, 321–333 (1968).

    Google Scholar 

  • Hanawalt, P. C., Haynes, R. H.: Repair replication of DNA in bacteria: irrelevance of chemical nature of base defect. Biochem. biophys. Res. Commun. 19, 462–467 (1965).

    Google Scholar 

  • Hausmann, R., Gold, M.: The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. 9. Deoxyribonucleic acid methylase in bacteriophage infected Escherichia coli. J. biol. Chem. 241, 1985–1994 (1966).

    Google Scholar 

  • Hayes, W.: High mutability genes. In: The genetics of Bacteria and their Viruses, 1st ed. Oxford: Blackwell 1964.

    Google Scholar 

  • Hayes, W.: The genetics of Bacteria and their viruses. Oxford: Blackwell 1971.

    Google Scholar 

  • Helling, R. B.: Selection of a mutant of Escherichia coli which has high mutation rates. J. Bact. 96, 975–980 (1968).

    Google Scholar 

  • Hill, R. F.: Ultraviolet-induced lethality and reversion to prototrophy in Escherichia coli strains with normal and reduced dark repair ability. Photochem. Photobiol. 4, 563–568 (1965).

    Google Scholar 

  • Hill, R. F.: Do dark repair mechanisms for UV-induced primary damage affect spontaneous mutations? Mutat. Res. 6, 472–475 (1968).

    Google Scholar 

  • Hill, R. F.: Location of genes controlling excision repair of UV damage and mutator activity in Escherichia coli WP2. Mutat. Res. 9, 341 (1970).

    Google Scholar 

  • Hill, C. W., Foulds, J., Soll, L., Berg, P.: Instability of a missense suppressor resulting from a duplication of genetic materia. J. molec. Biol. 39, 563 (1969).

    Google Scholar 

  • Hobom, G., Braunitzer, G.: Über Mutator-Mutanten des Phagen fd. Hoppe-Seylers Z. physiol. Chem. 348, 804 (1967).

    Google Scholar 

  • Howard-Flanders, P., Boyce, R. P.: DNA repair and genetic recombination: Studies on mutations of Escherichia coli defective in these processes. Radiat. Res. (Suppl.) 6, 156–184 (1966).

    Google Scholar 

  • Johnson, H. G., Bach, M. K.: Apparent suppression of mutation rates in bacteria by spermine. Nature (Lond.) 208, 408–409 (1966a).

    Google Scholar 

  • Johnson, H. G., Bach, M. K.: The antimutagenic action of polyamines: suppression of the mutagenic action of an E.coli mutator gene and of 2-aminpurine. Proc. nat. Acad. Sci. (Wash.) 55, 1453–1456 (1960b).

    Google Scholar 

  • Jyssum, K.: Observations on two types of genetic instability in Escherichia coli. Acta path. microbiol. scand. 48, 113–120 (1960).

    Google Scholar 

  • Jyssum, K.: Mutator factor in Neisseria menengitidis associated with increased sensitivity to ultraviolet light and defective transformation. J. Bact. 96, 165–172 (1968).

    Google Scholar 

  • Jyssum, K., Jyssum, S.: A genetic locus responsible for high mutability in Neisseria meningitidis. Acta path. microbiol. scand. 69, 52 (1967).

    Google Scholar 

  • Kada, T.: Mutator action induced by ultraviolet irradiation and lambdalysogenization in Escherichia coli K 12. Proc. XXI. Int. Congr. Genet. 1, 75 (1968).

    Google Scholar 

  • Kada, T.: Studies on the instability of Escherichia coli K-12. I. Suppression and high spontaneous mutations in a threonine auxotroph. Mutat. Res. 10, 103 (1970).

    Google Scholar 

  • Kato, T., Kondo, S.: Genetic and molecular characteristics of X ray sensitive mutants of Escherichia coli defective in repair synthesis. J. Bact. 104, 871 (1970).

    Google Scholar 

  • Kirchner, C. E.: The effect of the mutator gene on molecular changes and mutation in Salmonella t.m. LT2 and LT7. J. molec. Biol. 2, 331–338 (1960).

    Google Scholar 

  • Kirchner, C. E., Rudden, M. J.: Location of the mutator gene in Salmonella t.m. by cotransduction. J. Bact. 92, 1453–1456 (1966).

    Google Scholar 

  • Koch, A. L., Miller, C.: A mechanism for keeping mutations in check. J. theor. Biol. 8, 71 (1965).

    Google Scholar 

  • Koch, R. E.: The influence of neighbouring base pairs upon base-pair substitution mutation rates. Proc. nat. Acad. Sci. (Wash.) 68, 773 (1971).

    Google Scholar 

  • Kondo, S., Kato, T.: Action spectra for photoreactivation of killing and mutation to prototrophy in UV-sensitive strains of Escherichia coli possessing and lacking photoreactivating enzyme. Photochem. Photobiol. 5, 827–837 (1966).

    Google Scholar 

  • Liberfarb, R. M., Bryson, V.: Isolation characterization and genetic analysis of mutator genes in Escherichia coli B and K-12. J. Bact. 104, 363–375 (1970).

    Google Scholar 

  • Miyake, T.: Mutator factor in Salmonella typhimurium. Genetics 45, 11–14 (1960).

    Google Scholar 

  • Mohn, G.: Korrelation zwischen verminderter Reparaturfähigkeit für UV-Läsionen und hoher Spontanrate eines Mutatorstammes von E.coli K-12. Molec. Gen. Genet. 101, 43–50 (1968).

    Google Scholar 

  • Mohn, G., Kaplan, R. W.: Beeinflussung der spontanen und chemisch induzierten Mutabilität bei E. coli durch Änderung des genetischen Hintergrundes. Molec. Gen. Genet. 99, 191–202 (1967).

    Google Scholar 

  • Okada, Y., Streisinger, G., Owen, J., Newton, J., Tsugita, A., Inouye, M.: Molecular basis of a mutational hot spot in the lysozyme gene of bacteriophage T4. Nature (Lond.) 236 338 (1972).

    Google Scholar 

  • Orgel, A., Orgel, L. E.: Induction of mutations in bacteriophage T4 with divalent manganese. J. molec. Biol. 14, 453–457 (1965).

    Google Scholar 

  • Prozorov, A. A., Barabanshchikov, B. J.: The rate of spontaneous mutagenesis and the specificity of mutations initiating in the strains of Bacillus subtilis with a reduced capacity of genetic recombination. Genetika (Moskau) 4, 80 (1968).

    Google Scholar 

  • Schwartz, N. M.: Genetic instability in Escherichia coli. J. Bact. 89, 712 (1965).

    Google Scholar 

  • Siegel, E. C., Bryson, V.: Selection of resistant strains of Escherichia coli by antibiotics and antibacterial agents: role of normal and mutator strains. Antimicrobial Agents and Chemotherapy 1963, 629–634 (1964).

    Google Scholar 

  • Siegel, E. C., Bryson, V.: Mutator gene of Escherichia coli B. J. Bact. 94, 38–47 (1967).

    Google Scholar 

  • Skaar, P. D.: A binary mutability system in Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 42, 245–249 (1956).

    Google Scholar 

  • Smith-Keary, P. F., Dawson, G. W. P.: Episomic suppression of phenotype in Salmonella. Genet. Res. 5, 269 (1964).

    Google Scholar 

  • Sompolinsky, D., Ben-Yakov, M., Maboud, M., Boldur, I.: Transferable resistance factors with mutator effect in salmonella typhi. Mutat. Res. 4, 119 (1967).

    Google Scholar 

  • Speyer, J. F.: Mutagenic DNA polymerase. Biochem. biophys. Res. Commun. 21, 6–8 (1965).

    Google Scholar 

  • Speyer, J. F.: Base analogues and DNA polymerase mutagenesis. Fed. Proc. 28, 348 (1969).

    Google Scholar 

  • Speyer, J. F., Karam, J. D., Lenny, A. B.: On the role of DNA polymerase in base selection. Cold Spr. Harb. Symp. quant. Biol. 31, 693–697 (1966).

    Google Scholar 

  • Speyer, J., Karam, J., Rosenberg, D., Lenny, A.: Mutagenic polymerase in T4 phage. Cold Spr. Harb. Lab. quant. Biol. Ann. Report 11-12 (1967).

  • Suslova, N. G., Zakharov, I. A.: Study of the rate of spontaneous mutational process in X-ray sensitive mutants of Saccharomyces cerevisiae. Genetika (Moskau) 7, 91 (1971).

    Google Scholar 

  • Swartz, M. N., Nakamura, H., Lehman, I. R.: Activation of a defective DNA polymerase in a temperature sensitive mutant of bacteriophage T4. Virology 47, 338–353 (1971).

    Google Scholar 

  • Taylor, A. L.: Bacteriophage induced mutation in Escherichia coli. Proc. nat. Acad. Sci (Wash.) 50, 1043 (1963).

    Google Scholar 

  • Treffers, H. P., Spinelli, V., Belser, N. O.: A factor (or mutator gene) influencing mutation rates in Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 40, 1064–1071 (1954).

    Google Scholar 

  • Vinkler, G. N., Smyslova, G. I.: Antimutagenic and radioprotective activity of natural polyphenole complex. Citol. et Genet. 1, 5 (1967).

    Google Scholar 

  • Vinkler, G. N., Sticherbakov, V. K.: The discovery of a natural auto-antimutagenic system. Genetika (Moskau) 5, 52 (1967).

    Google Scholar 

  • Von Borstel, R. C., Cain, K. T., Steinberg, C. M.: Inheritance of spontaneous instability in yeast. Genetics 69, 17 (1971).

    Google Scholar 

  • Von Borstel, R. C., Graham, D. E., La Brot, K. L., Resnick, M. A.: Mutator activity of a X-radiation sensitive yeast. Genetics 60, 233 (1968).

    Google Scholar 

  • Warner, H. R., Barnes, J. E.: Deoxyribonucleic acid systhesis in Escherichia coli infected with some deoxyribonucleic acid polymerase-less mutants of bacteriophage T4. Virology 28, 100–107 (1966).

    Google Scholar 

  • Weinberg, R., Latham, A. B.: Apparent mutagenic effect of thymine deficiency for a thyminerequiring strain of Escherichia coli. J. Bact. 72, 570–572 (1956).

    Google Scholar 

  • Witkin, E. M.: Radiation-induced mutations and their repair. Science 152, 1345–1353 (1966).

    Google Scholar 

  • Witkin, E. M.: Mutation proof and mutation-prone modes of survival in derivates of Escherichia coli B differing in sensitivity to ultraviolet light. Brookhaven Symp. Biol. 20, 17–55 (1967).

    Google Scholar 

  • Witkin, E. M.: The role of DNA repair and recombination in mutagenesis. Proc. 12th Int. Congr. Genetics 111, 222–245 (1969).

    Google Scholar 

  • Yanofsky, C., Cox, E. C., Horn, V.: The unusual mutagenic specificity of an E.coli mutator gene. Proc. nat. Acad. Sci. (Wash.) 55, 274–281 (1966).

    Google Scholar 

  • Yoshikawa, M.: Drug sensitivity and mutability to drug resistance associated with the presence of an R factor. Genet. Res. 17, 1 (1971).

    Google Scholar 

  • Zakharov, I. A., Kozhina, T. N., Federova, I. V.: Effects de mutations vers la sensibilité au rayonnement ultraviolet chez la levure. Mutat. Res. 9, 31 (1970).

    Google Scholar 

  • Zamenhof, P. J.: A genetic locus responsible for generalized high mutability in Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 56, 845–852 (1966).

    Google Scholar 

  • Zamenhof, P.: Studies on the possible product of a bacterial mutator gene. Mutat. Res. 9, 549 (1970).

    Google Scholar 

  • Zamenhof, S.: Nucleic acids and mutability. Prog. Nucleic Acid Res. Mol. Biol. 6, 1–38 (1967).

    Google Scholar 

  • Zamenhof, S., Greer, S., De Giovanni, R.: Study of spontaneous gene unstabilization in E.coli. J. Bact. 75, 510 (1958).

    Google Scholar 

  • Zamenhof, S., Heldenmuth, L., Zamenhof, P.: Studies on mechanisms for the maintenance of constant mutability: Mutability and the resistance to mutagens. Proc. nat. Acad. Sci. (Wash.) 55, 50 (1966).

    Google Scholar 

Eukaryotes

  • Brink, R. A.: Very light variegated pericarp in maize. Genetics 39, 724–740 (1954).

    Google Scholar 

  • Brink, R. A.: Genetic repression of R action in maize. In: The role of chromosomes in development, M. Locke (Ed.) pp. 183–230. New York: Academic Press 1964.

    Google Scholar 

  • Davis, B. K.: A meiotic mutant resulting in precocious sister-centromere separation in Drosophila melanogaster. Ph. D. Dissertation, University of Washington, 1970.

  • Green, M. M.: The genetics of a mutator gene in Drosophila melanogaster. Mutat. Res. 10, 353–363 (1970).

    Google Scholar 

  • Hall, J. C.: The failure of two alleles of c(3)G to increase frequencies of X-linked lethals. Drosophila Information Service 47, 62 (1971).

    Google Scholar 

  • Ives, P. T.: The genetic structure of American populations of Drosophila melanogaster. Genetics 30, 167–196 (1945).

    Google Scholar 

  • Ives, P. T.: The importance of mutation rate genes in evolution. Evolution 4, 236–252 (1950).

    Google Scholar 

  • McClintock, B.: Chromosome organization and genetic expression. Cold Spr. Harb. Symp. quant. Biol. 16, 13–47 (1951).

    Google Scholar 

  • Magni, G. E.: Origin and nature of spontaneous mutations in meiotic organisms. J. cell. comp. Physiol. 64, Suppl. 1, 165–172 (1964).

    Google Scholar 

  • Magni, G. E., von Borstel, R. C.: Different rates of spontaneous mutations during mitosis and meiosis in yeast. Genetics 47, 1097–1108 (1962).

    Google Scholar 

  • Mampell, K.: High mutation frequency in Drosophila pseudoobscura race B. Proc. nat. Acad. Sci. (Wash.) 29, 137–144 (1943).

    Google Scholar 

  • Minamori, S., Ito, K.: Extrachromosomal element delta in Drosophila melanogaster. VI. Induction of recurrent lethal mutations in definite regions of second chromosome. Mutat. Res. 13, 361–369 (1971).

    Google Scholar 

  • Neel, J. V.: A study of high mutation rate in Drosophila melanogaster. Genetics 27, 519–536 (1942).

    Google Scholar 

  • Parry, D.: A meiotic mutant which causes a polarized disruption of chromosome pairing in female Drosophila melanogaster. Ph. D. Dissertation, University of Washington 1970.

  • Rhoades, M. M.: The genetic control of mutabilityin maize. Cold Spr. Harb. Symp. quant. Biol. 9, 138–144 (1941).

    Google Scholar 

  • Robbins, L. G.: Nonexchange alignment: A meiotic process revealed by a synthetic meiotic mutant of Drosophila melanogaster. Molec. Gen. Genet. 110, 144–166 (1971).

    Google Scholar 

  • Sandler, L., Lindsley, D. L., Nicoletti, B., Trippa, G.: Mutants affecting meiosis in natural populations of Drosophila melanogaster. Genetics 60, 525–558 (1968).

    Google Scholar 

  • Von Borstel, R. C.: On the origin of spontaneous mutations. Proc. XII. Int. Cong. Genetics 2, 124–125 (1968).

    Google Scholar 

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Authors and Affiliations

  1. Zentrallaboratorium für Mutagenitätsprüfung der DFG, Freiburg i. Br.

    G. Mohn & F. E. Würgler

  2. Zoologisches Institut der Eidgenössischen Technischen Hochschule, Zürich

    G. Mohn & F. E. Würgler

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  1. G. Mohn
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Mohn, G., Würgler, F.E. Mutator genes in different species. Humangenetik 16, 49–58 (1972). https://doi.org/10.1007/BF00393985

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