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T-lymphocyte subpopulations in the peripheral blood and bone marrow of patients with aplastic anemia

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Summary

A decrease in the absolute number of total lymphocytes, OKT3+ and OKT4+ lymphocytes, and a normal number of OKT8+ lymphocytes were found in the peripheral blood of patients with aplastic anemia. The OKT4: OKT8 ratio was decreased in patients due to a reduction in the percentage of OKT4+ cells and 3 out of 18 patients had a ratio less than 1. The values of the OKT4:OKT8 ratio were not associated either with the severity of the disease or with treatment with androgens. There was no correlation between the OKT4:OKT8 ratio and the number of transfusions received by patients. On the other hand, studies performed with bone marrow lymphocytes showed that the OKT4:OKT8 ratio for both patients and controls was lower than that of the peripheral blood. Since the ratio of OKT4:OKT8 cells in aplastic and control bone marrow was similar no direct pathogenic role can be assigned to the marrow for the imbalance detected in the peripheral blood.

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Authors and Affiliations

  1. Division of Hematology and Cytology, Department of Clinical Medicine, School of Medicine, 14.100 — Ribeirão Preto, São Paulo, Brazil

    R. P. Falcão, J. C. Voltarelli & C. Bottura

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  1. R. P. Falcão
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  2. J. C. Voltarelli
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  3. C. Bottura
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Falcão, R.P., Voltarelli, J.C. & Bottura, C. T-lymphocyte subpopulations in the peripheral blood and bone marrow of patients with aplastic anemia. Blut 50, 103–107 (1985). https://doi.org/10.1007/BF00321173

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  • DOI: https://doi.org/10.1007/BF00321173

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