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Influence of exposure mode on vinyl chloride action

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Abstract

Rats were subjected to 4 h continuous or intermittent exposure to vinyl chloride (VC) at different time-weighted average concentrations (15, 50, 150, 500 and 15,000 mg/m3). Hepatic non-protein sulfhydryl content (NPSH) and excretion of thiodiglycolic acid (TdGA) in urine were determined. VC at concentrations from 50 mg/m3 to 15,000 mg/m3 caused a dose-dependent depression of NPSH, but no difference in the magnitude of this depression induced by continuous or intermittent exposure at the same average concentration of VC was noted. At average concentrations of 50 mg/m3 and 150 mg/m3, the urinary excretion of TdGA under continuous exposure did not differ from that under intermittent exposure, whereas at VC concentrations of 500 mg/m3 and 15,000 mg/m3 it was higher following continuous exposure.

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Authors and Affiliations

  1. Department of Toxicity Evaluation, Institute of Occupational Medicine, Teresy 8, 90-950, Łódź, Poland

    Ryszard Andrzej Jedrychowski & Jerzy Andrzej Sokal

  2. Institute of Environmental Research and Bioanalysis, Department of Toxicology, Medical Academy, Narutowicza 120 a, 90-145, Łódź, Poland

    Jadwiga Chmielnicka

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  1. Ryszard Andrzej Jedrychowski
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  2. Jerzy Andrzej Sokal
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  3. Jadwiga Chmielnicka
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Jedrychowski, R.A., Sokal, J.A. & Chmielnicka, J. Influence of exposure mode on vinyl chloride action. Arch Toxicol 55, 195–198 (1984). https://doi.org/10.1007/BF00316128

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  • DOI: https://doi.org/10.1007/BF00316128

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