Summary
We examined changes in the tyrosine hydroxylase (TH)-immunoreactive fibers following 5 min of cerebral ischemia in gerbils using an immunohistochemical method 1, 3 and 30 days after ischemia. Almost all CA-1 pyramidal neurons were lost 3 days after ischemia, whereas noradrenergic fibers were maintained 30 days after ischemia. The present study demonstrated that TH-immunoreactive fibers and cells were resistant to transient ischemia, and that there was no sprouting or hyperactivity in noradrenergic systems after ischemia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Björklund A, Stenevi U (1977) Experimental reinnervation of the rat hippocampus by grafted sympathetic ganglia. I. Axonal regeneration along the hippocampal fimbria. Brain Res 138:259–270
Dehoff RT, Rhines FH (1981) Quantitative microscopy. McGraw-Hill, New York
Gage FH, Björklund A, Stenevi U (1983) Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents. Brain Res 268:27–37
Gage FH, Björklund A, Stenevi U (1984) Reinnervation released a neuronal survival factor in adult rat hippocampus. Nature 308:637–639
Izumiyama K, Kogure K (1988) Effect of dihydroergotoxine mesylate (Hydergine) on delayed neuronal death in the gerbil hippocampus. Acta Neurol Scand 78:214–220
Johansen FF, Jørgensen MB, Diemer NH (1983) Resistance of hippocampal CA-1 interneurons to 20 min of transient cerebral ischemia. Acta Neuropathol (Berl) 61:135–140
Kirino T (1984) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 291:373–377
Kirino T, Tamura A, Sano K (1990) Chronic maintenance of presynaptic terminals in gliotic hippocampus following ischemia. Brain Res 510:17–25
Miyauchi Y, Wielock T, Lindvall O (1989) Noradrenergic metabolism in neocortex and hippocampus following transient forebrain ischemia in rats: relation to development of selective neuronal necrosis. J Neurochem 53:408–415
Tomioka C, Nishioka K (1991) Decrease of presynaptic noradrenergic fiber density in rat hippocampus after transient ischemia. Acta Neurol Scand 85:343–355
Virginia MP, Tong HJ, Pauline MF, Carl GB, Domald JR (1975) Cellular localization of tyrosine hydroxylase by immunohistochemistry. J Histochem Cytochem 23:1–12
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tomioka, C., Nishioka, K. & Kogure, K. Resistance of hippocampal CA-1 noradrenergic fibers to five minutes of transient cerebral ischemia in the gerbil. Acta Neuropathol 84, 554–558 (1992). https://doi.org/10.1007/BF00304475
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00304475