Summary
The distribution of HLA class II antigens in the Asian Indian patients with rheumatoid arthritis (RA) was studied in the present investigation. The results demonstrated that DR4 was significantly increased in both northern (χ2=36.9, P<0.00001) as well as southern Indian (χ2=17.3, P<0.0001) patients. HLA haplotype analysis revealed the presence of B17-DR4 among southern Indians. Amongst northern Indians, four DR4 haplotypes occurred significantly: A1,B17,DR4; A19,B7, DR4; A30,B13,DR4; and A33,B44,DR4. An analysis of TA10 and DQ'Wa' specificities revealed that all the DR4-DQw3 positive northern Indian RA patients were DQw8 positive association observed between DR4-DQw7 and RA in some western Caucasian populations was not present in this series. A group of three DR4 positive RA patients were found to be DQw3 negative and DQ'Wa' or DQw4 positive. These results indicated that susceptibility to RA may be controlled by genes in the DR locus independent of any DQ associations.
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Tiwari JL, Terasaki PI (1985) Rheumatoid arthritis. In: Tiwari JL, Terasaki PI (eds) HLA and disease associations. UCLA Tissue Typing Laboratory, Los Angeles, Calif, pp 49–64
Mehra NK, Vaidya MC, Taneja V, Agarwal A, Malaviya AN (1982) HLA-DR antigens in rheumatoid arthritis in North India. Tissue Antigens 20:300–302
Malaviya AN, Mehra NK, Dasgupta B, Khan KM, Rao URK, Agarwal A, Tiwari SC (1983) Clinical and immunogenetic studies in rheumatoid arthritis in India. Rheumatol Int 3:105–108
Woodrow JC, Nichol FE, Zaphiropoulos G (1981) DR antigens and rheumatoid arthritis: a study of two populations. BMJ 283:1287–1288
Willkens RF, Hansen JA, Malmgren JA, Nisperos B, Mickelson EM, Watson MA (1982) HLA antigen in Yakima Indians with rheumatoid arthritis. Arthritis Rheum 25:1435–1439
Schiff B, Mizrachi Y, Orgad S, Yaron M, Gazit E (1982) Association of HLA-AW31 and HLA0DR1 with adult rheumatoid arthritis. Ann Rheum Dis 41:403–404
Papasteriades CA, Kappou ID, Skopouli FN, Barla MN, Fostiropoulos GA, Moutsopoulos HM (1985) Lack of HLA-antigen association in Greek rheumatoid arthritis patients. Rheumatol Int 5:201–203
Brautbar C, Naparstek Y, Yaron M, Amar A, Ehrenfeld M, Eliakim M, Bentwich Z, Cohen T, Korman Sh, Albert ED (1986) Immunogenetics of rheumatoid arthritis in Israel. Tissue Antigens 28:8–14
Christiansen FT, Kelly H, Dawkins RL (y1984) Rheumatoid arthritis. In: Albert ED, Baur MP, Mayr WR (eds) Histocompatibility testing 1984. Springer, Berlin Heidelberg New York, pp 378–383
Stastny P (1980) Joint report. In: Terasaki PI (ed) Histocompatibility testing 1980. Munksgaard, Copenhagen, pp 681–686
Yakura H, Wakisaka A, Aizawa M, Itakura K, Tagawa Y, Sugiura S (1976) HLA-D antigen of Japanese origin (LDWa) and its association with Vogt-Koyanagi-Hirada syndrome. Tissue Antigens 8:35–42
Bodmer JG, Marsh SGE, Albert E (1990) Nomenclature for factors of the HLA system, 1989. Immunol Today 11:3–9
Tait BD, Park MS, Barbetti A, Langley J, Terasaki PI, Aizawa M (1987) Antigen Society 28 Report (DOw3). In: Dupont BO (ed) Immunobiology of HLA, vol 1. Springer, Berlin Heidelberg New York, pp 269–273
Nepom BS, Palmer J, Kim SJ, Hansen JA, Holbeck SL, Nepom GT (1986) Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med 164:345–350
Singhal DP, D'Souza M, Reid B, Bensen WG, Kassam YB, Adachi JD (1987) HLA-DQ beta chain polymorphism in HLA-DR4 haplotypes associated with rheumatoid arthritis. Lancet II:1118–1120
Marsh SGE, Bodmer JG (1991) HLA class II nucleotide sequences, 1991. Hum Immunol 31:207–227
Sansom DM, Bidwell JL, Maddison PJ, Campion G, Klouda PT, Bradley BA (1987) HLA-DQ and DQB restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis. Hum Immunol 19:269–278
Lanchbury JSS, Sakkas LI, Marsh SGE, Bodmer JG, Welsh KI, Panayi GS (1989) HLA-DQB3-1 allele is a determinant of susceptibility to DR4 associated rheumatoid arthritis. Hum Immunol 26:59–71
Stephens HAF, Sakkas LI, Vaughan RW, Teitson I, Welsh KI, Panayi GS (1989) HLA DQw7 is a disease severity marker in patients with rheumatoid arthritis. Immunogenetics 30:119–122
McCusker CT, Reid B, Green D, Gladman DD, Buchanan WW, Singal DP (1991) HLA-D region antigens in patients with rheumatoid arthritis. Arthritis Rheum 34:192–199
Wallin J, Carlsson B, Strom H, Moller E (1988) A HLA-DR4 associated DR-DQ haplotype associated with rheumatoid arthritis. Arthritis Rheum 31:72–79
Ilonen J, Reijonen H, Arvilommi H, Jokinen I, Mottonen T, Hannonen P (1990) HLA-DR antigens and HLA-DQ B chain polymorphism in susceptibility to rheumatoid arthritis. Ann Rheum Dis 49:494–496
Festenstein H, Awad J, Hitman G, Cutbush G, Groves AV, Cassell P, Ollier W, Sachs JA (1986) New HLA DNA polymorphisms associated with autoimmune diseases. Nature 322:64–67
Perdriger A, Fauchet R, Chales G, Semana G, Ouillivic F, Lore P, Meadeb J, Pawlotsky Y (1990) RFLP study of the DR4-DQw7 haplotype in rheumatoid arthritis. Tissue Antigens 35:187–188
Nepom GT, Byers P, Seyfried C, Healey LA, Wilske KR, Stage D, Nepom BS (1989) HLA genes associated with rheumatoid arthritis: identification of susceptibility alleles using specific oligonucleotides probes. Arthritis Rheum 32:15–21
Wordsworth P (1991) PCR-SSO typing in HLA disease association studies. Eur J Immunogenet 18:139–146
Arnett FG, Edworthy SM, Bloch DA, McShone DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG (1988) The American Rheumatism Association 1987 revised criteria for classification of rheumatoid arthritis. Arthritis Rheum 31:315–324
Pitchappan RM, Manickasundari M, Kakkanaiah VN, Mahendran UN, Brahamjothi Bai V, ChandraMohan R, Subash Chander M, Rajasekhar R (1986) HLA antigen in Sourashtrans of Madurai. In: Aizawa M (ed) HLA in Asia Oceania 1986. Hokkaido University Press, Japan, pp 539–542
Baur MP (1977) Errata-corrige on some misprintings in the paper by Piazza ‘Haplotypes and linkage disequilibrium from the three locus phenotypes’. Tissue Antigens 9:181–186
Ohta N, Nishimura YK, Tanimoto K, Horiuchi Y, Abe C, Shiokawa Y, Abe T, Katagiri M, Yoshiki T, Sasazuki T (1982) Association between HLA and Japanese patients with rheumatoid arthritis. Hum Immunol 5:123–132
Ollier W, Venables PJW, Mumford PA, Maini RN, Awad J, Jaraquemada D, D'Amaro J, Festenstein H (1984) HLA antigen associations with extra-articular rheumatoid arthritis. Tissue Antigens 24:279–291
Olsen NJ, Callahan LF, Stastny P, Brooks RH, Nence EP, Kaye JJ, Pincus T (1988) Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis. Am J Med 84:257–264
Mody GM, Hammond MG, Naidoo PD (1989) HLA associations with rheumatoid arthritis in African Blacks. J Rheumatol 16:1326–1328
Oudshoorn M, Martell RW, Arendse B, Toit ED du (1991) Unusual HLA-DR, DQ haplotypes found in South African families of Black, Asian Indian and mixed ancestral origin. Hum Immunol 31:14–19
Cutbush SD, Ollier W, Awad J, Currey HLF, Festenstein H (1986) New HLA-DNA polymorphism associated with rheumatoid arthritis. Dis Markers 4:173–183
Fraser PA, Stern S, Larsen MG, Marcus-Bagley D, Awdeh Z, Glass DN, Alper CA (1990) HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies. Tissue Antigens 35:56–59
Gao X, Ball EJ, Dombrausky L, Olsen NJ, Pincus TP, Khan MA, Wolfe F, Stastny P (1988) Class II human leucocyte antigen genes and T cell receptor polymorphisms in patients with rheumatoid arthritis. Am J Med 85:14–16
Lee Nelson J, Hansen JA (1990) Autoimmune diseases and HLA. Crit Rev Immunol 10:307–328
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Taneja, V., Mehra, N.K., Chandershekaran, A.N. et al. HLA-DR4-DQw8, but not DR4-DQw7 haplotypes occur in Indian patients with rheumatoid arthritis. Rheumatol Int 11, 251–255 (1992). https://doi.org/10.1007/BF00301502
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DOI: https://doi.org/10.1007/BF00301502