Summary
A number of environmental factors are under discussion as possibly implicated in the etiology of RCU. On the basis of data in the literature and our own results, we attempted a critical weighing up of the possible contributions of climate, pollution, stress, nutrition in general and especially oxalate and minerals in the nutrition. It was concluded that there is a need for more in-depth research into the response of the body to challenges from the environment, in particular nutrition.
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Ackermann D, Baumann JM, Siegrist P (1988) Sulfatgehalt von Mineralwasser und Sulfaturie. Fortschr Urol Nephrol 26:254
Adlercreutz H (1990) Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand J Clin Lab Invest 50, Supp 1 201:3
Ahlstrand C, Tiselius HG (1990) Recurrences during a 10-year follow-up after first renal stone episode. Urol Res 18:397
Allison MJ, Cook HM, Milne DB,Gallagher S, Clayman RV (1986) Oxalate degradation by gastrointestinal bacteria from humans. J Nutr 116:455
Anderson DA (1973) Environmental factors in the etiology of urolithiasis. In: Cifuentes Delatte L, Rapado A, Hodgkinson A (eds) Urinary calculi Recent Advances in Aetiology. Stone Structure and Treatment. S Karger, Basel, p 130
Archer HE, Dormer AE, Scowen EF, Watts RWE (1957) Studies in the urinary secretion of oxalate by normal subjects. Clin Sci 16:405
Bär A (1985) Effect of high oral doses of xylitol versus glucose on urinary risk factors of urolithiasis in man. Int J Vit Nutr Res, Suppl 28:91
Barilla DE, Nolz C, Kennedy D, Pak CYC (1978) Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciurias. Am J Med 64:579
Binder HJ (1974) Intestinal oxalate absorption. Gastroenterology 67:441
Blacklock NJ (1969) The pattern of urolithiasis in the Royal Navy. In: Hodgkinson A, Nordin BEC (eds) Renal Stone Research Symposium. Churchill Livingstone, London, p 33
Blaustein MP (1974) The interrelatonship between sodium and calcium fluxes across cell membranes. Rev Physiol Biochem Pharmacol 70:33
Bonakdar S (1992) Immobilisations-Streß bei der Ratte-Wirkungen auf Mineralstoffwechsel und calciotrope Hormone, unter besonderer Beachtung des Einflusses von Schilddrüse und Nebenschilddrüsen. Dissertation Medizin, Universität Erlangen
Boskey AL, Goldberg MR, Posner AS (1978) Calcium-phospholipid-phosphate complexes in mineralizing tissues. Proc Soc Exp Biol Med 157:590
Breslau NA, McGuire JL, Zerwekh JE, Pak CYC (1982) The role of dietary sodium on renal excretion and intestinal absorption of calcium on vitamin D metabolism. J Clin Endocrinol Metab 55:369
Brinkley L, McGuire J, Gregory J, Pak CYC (1981) Bioavailability of oxalate in foods. Urology XVII:534
Broadus AE, Insogna KL, Lang R, Ellison AF, Dreyer BE (1984) Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria. New Engl J Med 311:73
Brockis JG, Levitt AJ, Cruthers SM (1982) The effects of vegetable and animal protein diets on calcium, urate, and oxalate excretion. Brit J Urol 54:590
Brown JC, McIntosh CHS, Pederson RA (1983) The gastrointestinal peptides and nutrition. Can J Physiol Pharmacol 62:282
Buchet JP, Lauwerys R, Roels H et al (1990) Renal effects of cadmium body burden of the general population. Lancet 336:699
Buck AC, Davies RL, Harrison T (1991) The protective role of eicosapentaenoic acid (EPA) in the pathogenesis of urolithiasis. J Urol 146:188
Cifuentes Delatte L, Rapado A, Hodgkinson A (1973) Urinary Calculi Recent Advances in Aetiology, Stone Structure and Treatment. S Karger, Basel
Coe FL, Farcis MJ, Crocket T, Strauss AL, Parks JH, Porat A, Gant CL, Sherwood LM (1982) Effects of low-calcium diet on urine calcium excretion, parathyroid function and serum 1,25-(OH)2D levels in patients with idiopathic hypercalciuria and in normal subjects. Am J Med 72:25
Conyers RA, Bais R, Rofe AM (1990) The relation of clinical catastrophes, endogenous oxalate production, and urolithiasis. Clin Chem 36:1717
Cunningham TJ, Cunningham MM (1938) Dietary magnesium and urinary calculi. New Zeal J Sci Tech 19:529
Duranti E, Sasdelli M (1989) Effects of dietary sodium on lithogenic risk factors. In: Walker VR, Sutton RAL, Cameron ECB, Pak CYC, Robertson WG (eds) Urolithiasis, Plenum Press, New York, p 747
Earnest DL, Williams HE, Admirand WH (1975) A physicochemical basis for treatment of enteric hyperoxaluria. Trans Assoc Am Phys 88:224
Feitelberg S, Epstein S, Ismail F, D'Amanda C (1987) Deranged bone mineral metabolism in chronic alcoholism. Metab 36:322
Fellstroem B, Danielson BG, Karlstroem B, Lithell H, Ljunghall S, Vessby B (1989) Dietary habits in renal stone patients compared with healthy subjects. Brit J Urol 63:575
Fleisch H, Robertson WG, Smith LH, Vahlensieck W (1976) Urolithiasis Research. Plenum Press, New York
Fleisch H (1990) Role of inhibitors and promoters of crystal nucleation, growth and aggregation in the formation of calcium stones. In: Wickham JEA, Buck AC (eds) Renal Tract Stone. Metabolic Basis and Clinical Practice. Churchill Livingstone, New York, p 295
Florin T, Neate G, Gibson GR, Christl SU, Cummings JH (1991) Metabolism of dietary sulphate: absorption and excretion in humans. Gut 32:766
Friberg L (1950) Health hazards in the manufacture of accumulators with special reference to chronic cadmium poisoning. A clinical and experimental study. Acta Med Scand, Suppl 7
Goldfarb S (1988) Dietary factors in the pathogenesis and prophylaxis of calcium nephrolithiasis. Kidney Int 34:544
Goldfarb S (1990) The role of diet in the pathogenesis and therapy of nephrolithiasis. Endocrinol Metab Clin N Am 19:805
Griffith HM, O'Shea B, Kevany JP, McCormick JS (1981) A control study of dietary factors in renal stone formation. Brit J Urol 53:416
Hallson PC, Kasidas GP (1990) Hyperoxaluria in calcium oxalate urolithiasis. In: Wickham JEA, Buck AC (eds) Renal Tract Stone. Metabolic Basis and Clinical Practice. Churchill Livingstone, New York, p 271
Heaney RP, Weaver CM (1989) Oxalate: effect on calcium absorbability. Am J Clin Nutr 50:830
Henrotte JG, Plouin PF, Levy-Leboyer C, Moser G, Sidoroff-Girault N, Franck G, Santarromana M, Pineau M (1985) Blood and urinary magnesium, zinc, calcium, free fatty acids, and catecholamines in type A and type B subjects. J Am Coll Nutr 4:165
Hodgkinson A, Nordin BEC (1969) Renal Stone Research Symposium. Churchill Livingstone, London
Hodgkinson A, Williams A (1972) An improved colorimetric procedure for urinary oxalate. Clin Chim Acta 36:127
Hughes C, Dutton S, Stewart Truswell A (1981) High intakes of ascorbic acid and urinary oxalate. J Hum Nutr 35:274
Irving RA, Noakes TD, Rodgers AL, Swartz L (1986) Crystalluria in marathon runners. I. Standard marathon-males. Urol Res 14:289
Itoh R, Oka I, Echizen H, Yamada K, Suyama Y, Murakami K (1991) The interrelation of urinary calcium and sodium intake in healthy elderly Japanese. Internat J Vit Nutr Res 61:159
Jaeger P, Portmann L, Jacquet AF, Burckhardt P (1984) Drinking water for stone formers: is the calcium content relevant? Eur Urol 10:53
Jaeger P, Portmann L, Jacquet AF, Burckhardt P (1985) Influence of the calcium content of the diet on the incidence of mild hyperoxaluria in idiopathic renal stone formers. Am J Nephrol 5:40
Jaeger P (1989) Mechanism of idiopathic hypercalciuria: A search for a unifying hypothesis. In: Walker VR, Sutton RAL, Cameron ECB, Pak CYC, Robert son WG (eds) Urolithiasis. Plenum Press, New York, p 321
Johannson G, Backmann U, Danielson BG, Ljunghall S, Wikstroem B (1980) Magnesium metabolism in renal stone disease. Invest Urol 18:93
Kasidas GP, Rose GA (1980) Oxalate content of some common foods: determination by an enzymatic method. J Hum Nutr 34:255
Kasper H (1990) Der Einfluß von Ballaststoffen auf die Ausnützung von Nährstoffen und Pharmaka. In: Rottka H (ed) Pflanzenfasern-Ballaststoffe in der menschlichen Ernährung. Thieme Verlag, Stuttgart, p 93
Khan SR, Shevock PN, Hackett RL (1988) Presence of lipids in urinary stones: Results of preliminary studies. Calcif Tissue Int 42:91
Knowles JB, Wood RJ, Rosenberg JH (1988) Response of fractional calcium absorption in women to various coadministered oral glucose doses. Am J Clin Nutr 48:1471
Kohri K, Kodama M, Ihikawa Y, Katayama Y, Takada M, Katoh Y, Kataoka K, Iguchi M, Kurita T (1989) Magnesium-to-calcium ratio in tap water, and its relationship to geological features and the incidence of calcium-containing urinary stones. J Urol 142:1272
Kok DJ, Iestra JA, Doorenbos CJ, Papapoulos SE (1990) The effects of dietary excess in animal protein and in sodium on the composition and the crystallization kinetics of calcium oxalate monohydrate in urines of healthy men. J Clin Endocrinol Metab 71:861
Krishnamra N, Limlongwongse L (1987) The in vivo effect of ethanol on gastrointestinal motility and gastrointestinal handling of calcium in rats. J Nutr Sc Vitaminol 33:89
Kurien TB, Selvam R (1989) Induction of lipid peroxidation in calcium oxalate stone formation. Ind J Exp Biol 27:450
Landes RR, Melnick I, Sierakowski R, Finlayson B (1977) An inquiry into the relation between water hardness and the frequency of urinary stones. In: Seelig MS (ed) Nutritional Imbalances in Infant and Adult Disease: Mineral, Vitamin D, and Cholesterol. Spectrum Publications, New York, p 9
Larsson L, Tiselius HG (1987) Hyperoxaluria. Min Electr Metab 13:242
Lemann J (1985) Urinary calcium excretion and net acid excretion: Effects of dietary protein, carbohydrate and calories. In: Schwille PO, Smith LH, Robertson WG, Vahlensieck W (eds) Urolithiasis and Related Clinical Research. Plenum Press, New York, p 53
Li MK, Blacklock JN, Garside J (1985) Effects of magnesium on calcium oxalate crystallization. J Urol 133:123
Li MK, Kavanagh PJ, Prendiville V, Buxton A, Moss DG, Blacklock NJ (1986) Does sucrose damage kidney? Brit J Urol 58:353
Lietman M, Landis W (1988) Relationship of mineral balance to oxalate degradation during high oxalate feeding. Nutr Rep Int 38:313
Marier JR (1990) Dietary magnesium and drinking water: effects on human health status. In: Sigel H, Sigel A (eds) Metal ions in biological systems, vol. 26. Marcel Dekker, New York, p 85
Marks V (1985) How food affects our hormones. Clin Biochem 18:149
McCarron DA, Rankin LJ, Bennet WM, Krutzik S, McClung MR, Luft FC (1981) Urinary calcium excretion at extremes of sodium intake in normal man. Am J Nephrol 1:84
Meierhofer WJ, Gray RW, Cheung HS, Lemann Jr J (1983) Bone resorption stimulated by elevated 1,25-(OH)2 vitamin D concentrations in healthy men. Kidney Int 24:555
Meikle AW, Stringham JD, Woodward MG, McMurry MP (1990) Effects of a fat-containing meal on sex hormones in men. Metab 39:943
Muldowney FP, Freaney R, Moloney MF (1982) Importance of dietary sodium in the hypercalciuria syndrome. Kidney Int 22:292
Nakada T, Sasagawa J, Furuta H, Katayama T, Shimazaki J (1988) Effect of high-calcium diet on urinary oxalate excretion in urinary stone formers. Eur Urol 15:264
Nath R, Thind SK, Murthy MSR, Talwar HS, Farooqui S (1984) Molecular aspects of idiopathic urolithiasis. Molec Asp Med 7:7
Nguyen NU, Dumoulin G, Wolf PJ, Bourderont D, Bertenlay S (1986) Urinary calcium and oxalate excretion in response to oral glucose load in man. Horm Metab Res 18:869
Nguyen NU, Dumoulin G, Wolf PJ, Betenlay S (1989) Urinary calcium and oxalate excretion during oral fructose or glucose load in man. Horm Metab Res 21:96
Ollenschläger G (1991) Eine Analyse der “Nationalen Verzehrsstudie”. Dtsch Ärztebl 88:2216
Oxley JA, Bruckdorfer KR (1979) The effect of dietary carbohydrates and other dietary constituents in the rat. Proc Nutr Doc 38:85 A
Rao PN, Gordon C, Davies D, Blacklock NJ (1982) Are stone formers maladapted to refined carbohydrates? Brit J Urol 54:575
Rao PN, Gowland E, Kane J, Lythgoe S, Rollason JG, Blacklock NJ, Rigby AS (1987) Urolithiasis and atherosclerosis — is there an association? Urol Res 15:117 (abstract)
Robertson WG, Peacock M, Heyburn PJ, Marshall DH (1978) The role of affluence and diet in the genesis of calcium containing stones. Fortschr Urol Nephrol 11:5
Robertson WG, Heyburn PJ, Peacock M, Hanes FA, Swaminathan R (1979) The effect of high animal protein intake on the risk of calcium stone-formation in the urinary tract. Clin Sci 57:285
Robertson WG, Peacock M, Heyburn PJ, Hanes F, Rutherford A, Clementson E, Swaminathan R, Clark PB (1979) Should recurrent calciumcontaining stone-formers become vegeterians? Brit J Urol 51:427
Robertson WG, Peacock M (1980) The cause of idiopathic calcium stone disease: hypercalciuria or hyperoxaluria. Nephron 26:105
Robertson WG, Peacock M, Ouimet D, Heyburn PJ, Rutherford A (1981) The main risk factor for calcium oxalate stone disease in man: Hypercalciuria or mild hyperoxaluria? In: Smith LH, Robertson WG, Finlayson B (eds) Urolithiasis. Clinical and Basic Research. Plenum Press, New York, p 3
Robertson WG (1985) Dietary factors important in calcium stone formation. In: Schwille PO, Smith LH, Robertson WG, Vahlensieck W (eds) Urolithiasis and Related Clinical Research. Plenum Press, New York, p 61
Robertson WG (1987) Diet and calcium stones. Min Electr Metab 13:228
Robertson WG (1990) Epidemiology of urinary stone disease. Urol Res 18, Suppl S3
Rose AG (1986) Medical investigation and treatment of urinary stones: a search for new ideas. Clin Chim Acta 160:109
Rümenapf G, Schmidtler J, Schwille PO (1990) Intestinal calcium absorption during hyperinsulinemic euglycemic glucose clamp in healthy humans. Calcif Tissue Int 46:73
Salimi LH, Heughebaert JC, Nancollas GH (1985) Crystal growth of calcium phosphates in the presence of magnesium ions. Langmuir 1:119
Scholz D, Schwille PO, Sigel A (1982) Ernährungsgewohnheiten von Patienten mit Urolithiasis. Fortschr Urol Nephrol 17:83
Schumann HJ (1963) Die Häufigkeit der Urolithiasis im Sektionsgut des Pathologischen Instituts St. Georg. Leipzig. Zentralbl Allg Pathol 105:88
Schwille PO, Scholz D, Hagemann G, Sigel A (1974) Metabolic and glucose load studies in uric acid, oxalate, and hyperparathyroid stone formers. Adv Exp Biol Med 41 B:489
Schwille PO (1979) A survey of calcium urolithiasis in normocalcaemic hypercalciuria: Possible role of nutrients and diet-mediated factors. Urol Res 7:149
Schwille PO, Hanisch E, Scholz D (1984) Postprandial hypercalciuria and intestinal oxalate absorption in idiopathic renal stone disease. J Urol 132:650
Schwille PO, Hamper A, Sigel A (1985) Urinary and serum sulfate in idiopathic recurrent calcium urolithiasis. In: Schwille PO, Smith LH, Robertson WG, Vahlensieck W (eds) Urolithiasis and Related Clinical Resarch. Plenum Press, New York, p 339
Schwille PO, Smith LH, Robertson WG, Vahlensieck W (1985) Urolithiasis and Related Clinical Research. Plenum Press, New York
Schwille PO, Rümenapf G, Schreiber B (1988) Urinary sodium in renal calcium lithiasis — an approach to its relationship with urinary calcium, and the possible role of atrial natriuretic peptide (h-ANP). Fortschr Urol Nephrol 26:167
Schwille PO, Manoharan M, Rümenapf G, Wölfel G, Berens H (1989) Oxalate measurement in the picomol range by ion chromatography: Values in fasting plasma and urine of controls and patients with idiopathic calcium urolithiasis. J Clin Chem Clin Biochem 27:87
Schwille PO, Rümenapf G, Köhler R (1989) Blood levels of glucometabolic hormones and urinary saturation with stone forming phases after an oral test meal in male patients with recurrent idiopathic calcium urolithiasis and in healthy controls. J Am Coll Nutr 8:557
Schwille PO, Bornhof C, Schöne H, Töpper K (1990) Mineral metabolism and solution depletion studies in fasting urine and serum of pre-ESWL kidney stone patients — Results of a pilot trial. Urol Res 18:69 (abstract)
Schwille PO, Schöne H, Töpper K (1990) Increased complex binding of serum calcium (Ca) in idiopathic calcium urolithiasis with normo-(NC) or hypercalciuria (HC). Urol Res 18:69 (abstract)
Schwille PO, Töpper K, Schwille K, Herrmann U (1991) Recurrent idiopathic calcium urolithiasis (RCU)-Blood levels of two vitamin D metabolites in males. In: Proceedings of the Eighth International Workshop on Vitamin D, July 5–10, Paris
Scott R, Fitzgerald-Finch OP, Cunningham C, Ottoway JM, Fell GS (1981) The importance of chronic cadmium poisoning in renal stone formation — A five year study. In: Smith LH, Robertson WG, Finlayson B (eds) Urolithiasis. Clinical and Basic Research. Plenum Press, New York, p 353
Sedrani SH, Al-Arabi KM, Abanmy A, Elidrissy A, Lawson DEM (1991) Circulating levels of 25-hydroxyvitamin D in Saudi population in relation to age, sex, and type of house. Eighth Workshop on Vitamin D. July 5–10. Paris (abstract)
Sharma V, Schwille PO (1992) The effect of calcium on oxalate uptake and transport by rat intestine in vitro and in vivo. Scand J Clin Lab Invest (accepted)
Shier NW (1984) The relationship of dietary protein, protein type and magnesium to urinary magnesium excretion in the human. Nutr Rep Int 29:1301
Shuster J, Finlayson B, Schaefer RL, Sierakowski R, Zoltek J, Dzegede S (1985) Primary liquid intake and urinary stone. J Chron Dis 38:907
Silver J, Rubinger D, Friedländer MM, Popovtzer MM (1983) Sodium-dependent idiopathic hypercalciuria in renal-stone formers. Lancet-August 27:484
Smith LH, Robertson WG, Finlayson B (1981) Urolithiasis. Clinical and Basic Research. Plenum Press, New York
Smith CL, Berkseth RO (1989) Lack of a relationship between calcium excretion and sodium excretion in stone formers with high fasting calcium/creatinine ratios. In: Walker VR, Sutton RAL, Cameron ECB, Pak CYC, Robertson WG (eds) Urolithiasis. Plenum Press, New York, p 367
Spiess U (1987) Fasern in der Nahrung von Patienten mit calcium-haltigen Nierensteinen-Eine Pilotstudie mit Kontrollgruppe. Dissertation Medizin, Universität Erlangen
Sutton RAL, Walker VR (1980) Responses to hydrochlorthiazide and azetazolamide in patients with calcium stones. New Engl J Med 302:709
Takasaki E (1972) The magnesium calcium ratio in the concentrated urines of patients with calcium oxalate calculi. Invest Urol 10:147
Takasaki E (1987) Urolithiasis in Japan. Asian Med J 30:90
Thomas jr WC, Malagodi MH, Rennert OM (1981) Amino acids in urine and blood of calculous patients. J Urol 19:115
Walker RM, Linkswiler HM (1972) Calcium retention in the adult human male as affected by protein intake. J Nutr 102:1297
Walker VR, Sutton RAL, Cameron ECB, Pak CYC, Robertson WG (1989) Urolithiasis. Plenum Press, New York
Weiss RE, Gorn A, Dux S, Nimni ME (1981) Influence of high protein diets on cartilage and bone formation in rats. J Nutr 111:804
Whang R, Welt LG (1963) Observations in experimental magnesium depletion. J Clin Invest 42:305
Williams G, Sallis JD (1982) Structural factors influencing the ability of compounds to inhibit hydroxyapatite formation. Calcif Tissue Int 34:169
Wilson DM, Smith LH, Erickson SB, Torres VE, Liedtke RR (1989) Renal oxalate handling in normal subjects and patients with idiopathic renal lithiasis: primary and secondary hyperoxaluria. In: Walker VR, Sutton RAL, Cameron ECB, Pak CYC, Robertson WG (eds) Urolithiasis. Plenum Press, New York, p 53
Wood RJ, Gerhardt A, Rosenberg JH (1987) Effects of glucose and glucose polymers on calcium absorption in healthy subjects. Am J Clin Nutr 46:699
Zarembski PM, Hodgkinson A (1962) The oxalic acid content of English diet. Brit J Nutr 16:627
Zechner O, Schreiber V (1985) Alcohol as an epidemiologic risk factor in urolithiasis. In: Schwille PO, Smith LH, Robertson WG, Vahlensieck W (eds) Urolithiasis and Related Clinical Research. Plenum Press, New York, p 315
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Schwille, P.O., Herrmann, U. Environmental factors in the pathophysiology of recurrent idiopathic calcium urolithiasis (RCU), with emphasis on nutrition. Urol. Res. 20, 72–83 (1992). https://doi.org/10.1007/BF00294342
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DOI: https://doi.org/10.1007/BF00294342