Abstract
Two cases (first cases from Poland and Eastern Europe) with liver injury due to amoxycillin-clavulanic acid (augmentin) are reported. Pruritus and jaundice were the main symptoms. Liver biopsy revealed mixed hepatocellular-cholestatic liver injury in both cases. In addition, in one case the microgranulomalike aggregate of inflammatory cells was found. Clinical and laboratory abnormalities returned to normal within 13 weeks.
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References
Larrey D, Vial T, Micaleff A, Babany G, Morichau-Bequachant M, Michel H et al (1992) Hepatitis associated with amoxycillin-clavulanic acid combination report of 15 cases. Gut 33:368–371
Lee W M (1993) Review article: drug induced hepatotoxicity. Aliment Pharmacol Ther 7:477–485
Reddy R K, Brillant P, Schiff E R (1989) Amoxicillin-clavulanate potassium-associated cholestasis. Gastroenterology 96:1135–1141
Ryan J, Dudley F (1992) Cholestatic hepatitis asociated with clavulanic acid (letter). Gut 33:1583
Schneider J, Kleinman M, Kupiec J (1989) Cholestatic hepatitis after therapy with amoxicillin/clavulanate potassium. NY State J Med 89:355–356
Silvain C, Fort E, Levillain P, Labat-Labourdette J, Beauchant M (1992) Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid. Dig Dis Sci 37:150–152
Stricker B, Van den Broek J, Keuning J, Eberhardt W, Houben H, Johnson M et al (1989) Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin). Dig Dis Sci 34:1576–1580
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Habior, A., Walewska-Zielecka, B. & Butruk, E. Hepatocellular-cholestatic liver injury due to amoxycillin-clavulanic acid combination. Clin Investig 72, 616–618 (1994). https://doi.org/10.1007/BF00227455
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DOI: https://doi.org/10.1007/BF00227455