Summary
Various types of synaptic formations on pinealocytes and pineal neurons were found in the pineal body of Macaca fuscata. Axo-somatic synapses of the Gray type-II category were detected on the pinealocyte cell body. Gap junctions and ribbon synapses were observed between adjacent pinealocytes. About 70 nerve-cell bodies were detected in one half of the whole pineal body bisected midsagittally. They were localized exclusively deep in the central part. When examined electron-microscopically, they were found to receive ribbon-synapse-like contacts from pinealocytic processes. They also received synaptic contacts of the Gray type-I category on their dendrites, and those of the Gray type-II category on their cell bodies from nerve terminals of unknown origin. All these synapse-forming axon terminals contained small clear vesicles. Thus, the pineal neurons of the monkey, at least in part, are suggested to be derived from the pineal ganglion cells in the lower vertebrates and not from the postganglionic parasympathetic neurons. The functional significance of these observations is discussed in relation to the innervation of the pineal body of the monkey.
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References
David GFX, Herbert J (1973) Experimental evidence for a synaptic connection between habenula and pineal ganglion in the ferret. Brain Res 64:327–343
David GFX, Kumar TCA (1978) Histochemical localization of cholinesterase in the neural tissue of the pineal in the rhesus monkey. Experientia 34:1067–1068
David GFX, Herbert J, Wright GDS (1973) The ultrastructure of the pineal ganglion in the ferret. J Anat 115:79–97
David GFX, Umberkomman B, Kumar K, Kumar TCA (1975) Neuroendocrine significance of the pineal. In: Knigge KM, Scott DE, Kobayashi H, Ishii S (eds) Brain-Endocrine interaction II. The ventricular system 2nd Int Symp. S. Karger, Basel pp 365–375
Herbert J (1971) The role of the pineal in the control by light of the reproductive cycle of the ferret. In: Wolstenholme GEW, Knight J (eds) The pineal gland. Churchill, London, pp 303–327
Huang HT, Lin HS (1984) Synapticy junctions between the adrenergic axon varicosity and the pinealocyte in the rat. J Pineal Res 1:281–291
Huang SK, Taugner R (1984) Gap junctions between guinea-pig pinealocytes. Cell Tissue Res 235:137–141
Hülsemann M (1967) Vergleichende histologische Untersuchungen über das Vorkommen von Gliafasern in der Epiphysis cerebri von Säugetieren. Acta Anat 66:249–278
Jung D, Vollrath L (1982) Structural dissimilarities in different regions of the pineal gland of Pirbright White guinea-pigs. J Neural Transm 54:117–128
Kappers JA (1965) Survey of the innervation of the epiphysis cerebri and the accessory pineal organs of the vertebrates. In: Kappers JA, Shade JP (eds) Structure and function of the epiphysis cerebri. Progr Brain Res 10:87–153
Kappers JA (1979) Short history of pineal discovery and research. Progr Brain Res 52:3–22
Kenny GTC (1961) The “nervi conarii” of the monkey. An experimental study. J Neuropathol Exp Neurol 20:563–570
Kolmer W (1929) Ganglienzellen als konstanter Bestandteil der Zirbel von Affen. Z Ges Neurol Psychiat 121:423–428
Matsushima S, Reiter RJ (1977) Fine structural features of adrenergic nerve fibers and endings in the pineal gland of the rat, ground squirrel and chinchilla. Am J Anat 148:463–478
Matsushima S, Reiter RJ (1978) Electron microscopic observations on neuron-like cells in the ground squirrel pineal gland. J Neuraltransm 42:223–237
Nielsen JT, Möller M (1975) Nervous connections between the brain and the pineal gland in the cat (Felis catus) and the monkey (Cercopilhecus aethiops). Cell Tissue Res 161:293–301
Novotna B, Ulvrova L, Hromada J (1966) Some observations on the pineal body of Macaques. Folia Morphol 14:1–6
Romijn HJ (1973a) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.) I. A light microscopic investigation. Z Zellforsch 139:473–485
Romijn HJ (1973b) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.) II. An electron microscopic investigation of the pinealocytes. Z Zellforsch 141:545–560
Romijn HJ (1973c) Parasympathetic innervation of the rabbit pineal gland. Brain Res 157:25–51
Romijn HJ (1975) Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.) III. An electron microscopic investigation of the innervation. Cell Tissue Res 157:25–51
Sheridan MN, Sladek JR (1975) Histofluorescence and ultrastructural analysis of hamster and monkey pineal. Cell Tissue Res 164:145–152
Taugner R, Schiller A, Rix E (1981) Gap junctions between pinealocytes. Cell Tissue Res 218:303–314
Trueman J, Herbert J (1970) Monoamines and acetyl-cholinesterase in the pineal gland and habenula of the ferret. Z Zellforsch 109:83–100
Ueck M (1979) Innervation of the vertebrate pineal. Progr Brain Res 52:45–88
Vollrath L (1981) The pineal organ. In: Oksche A, Vollrath L (eds) Handbuch der Mikroskopischen Anatomie des Menschen VI/7. Springer, Berlin Heidelberg New York
Wartenberg H (1968) The mammalian pineal organ: electron microscopic studies on the fine structure of pinealocytes, glial cells and on the perivascular compartment. Z Zellforsch 86:74–97
Wood JG (1973) The effect of niamid and reserpine on the nerve endings of the pineal gland. Z Zellforsch 145:151–166
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Ichimura, T., Arikuni, T. & Hashimoto, P.H. Fine-structural study of the pineal body of the monkey (Macaca fuscata) with special reference to synaptic formations. Cell Tissue Res. 244, 569–576 (1986). https://doi.org/10.1007/BF00212535
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DOI: https://doi.org/10.1007/BF00212535