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Noninvasive perfusion imaging of human brain tumors with EPISTAR

  • Neuroradiology
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Abstract

A total of 17 patients with histologically proven diagnoses of low-grade astrocytoma (n = 4), high-grade astrocytoma (n = 8), lymphoma (n = 3), and meningioma (n = 2) were examined by using EPISTAR MR imaging. Meningiomas had the highest EPISTAR tumor/white matter contrast and low-grade astrocytomas and lymphomas the lowest. High-grade astrocytomas demonstrated elevated EPISTAR signal with marked regional heterogeneity. There was agreement between tumor vascularity by SPECT and EPISTAR in the five cases where both were done. Our results show that tumor vascularity can be assessed qualitatively by using EPISTAR without the need for contrast medium injection.

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References

  1. Felix R, Schörner W, Laniado M et al (1985) Brain tumors: MR imaging with gadolinium-DTPA. Radiology 156: 681–688

    Google Scholar 

  2. Schweighofer BW, Klein MV, Wesby G, Hesselink JR (1990) Clinical experience with routine Gd-DTPA administration for MR imaging of the brain. J Comput Assist Tomogr 14: 11–17

    Google Scholar 

  3. DiChiro G, Oldfield E, Wright DC et al (1988) Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies. AJR 150: 189–197

    Google Scholar 

  4. Schwartz RB, Carvalho PA, Alexander P III, Loeffler JS, Folkerth R, Holman BL (1991) Radiation necrosis vs high-grade recurrent glioma: differentiation by using Tc-99mHMPAO. AJNR 12: 1187–1192

    Google Scholar 

  5. Belliveau JW, Rosen BR, Kantor HL et al. (1990) Functional cerebral imaging bt susceptibility-contrast NMR. Magn Reson Med 14: 538–546

    Google Scholar 

  6. Edelman RR, Mattle HP, Atkinson DJ et al. (1990) Cerebral blood flow: assessment with dynamic contrast-enhanced T2*-weighted MR imaging at 1.5 T. Radiology 176: 211–220

    Google Scholar 

  7. Rosen BR, Belliveau JW, Aaronen HJ et al (1991) Susceptibility contrast imaging of cerebral blood volume: human experience. Magn Reson Med 22: 293–299

    Google Scholar 

  8. Maeda M, Itoh S, Kimura H et al. (1993) Tumor vascularity in the brain: evaluation with dynamic susceptibility-contrast MR imaging. Radiology 189: 233–238

    Google Scholar 

  9. Aronen HJ, Gazit IE, Louis DN et al (1994) Cerebral blood volume maps of gliomas. Comparison with tumor grade and histologic findings. Radiology 191: 41–51

    CAS  PubMed  Google Scholar 

  10. Edelman RR, Siewert B, Darby DG et al (1994) Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radiofrequency. Radiology 192: 513–520

    Google Scholar 

  11. Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system, 2nd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

  12. Daumas-Dupont C, Scheithauer B, O'Fallon J, Kelly P (1988) Grading of astrocytomas: a simple and reproducible method. Cancer 62: 2152–2165

    Google Scholar 

  13. Tyler JL, Diksic M, Villemure JG et al (1987) Metabolic and hemodynamic evaluation of gliomas using positron emission tomography. J Nucl Med 28: 1123–1133

    Google Scholar 

  14. LeBihan D, Turner R, Patronas N, Douek P (1990) Intravoxel incoherent motion echo-planar imaging and susceptibility induced, contrast-enhanced EPI: comparison of two approaches to real-time perfusion MR Imaging. Radiology 177(P): 120

    Google Scholar 

  15. Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23: 37–45

    Google Scholar 

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Correspondence to: J. Gaa

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Gaa, J., Warach, S., Wen, P. et al. Noninvasive perfusion imaging of human brain tumors with EPISTAR. Eur. Radiol. 6, 518–522 (1996). https://doi.org/10.1007/BF00182486

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  • DOI: https://doi.org/10.1007/BF00182486

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