Abstract
Apart from the presence or absence of metastases in patients with laryngeal carcinoma, there are changes of reactivity in cervical lymph nodes that are seen histologically as nonspecific reactive lymphadenitis. These changes are morphological manifestations of the regional lymphatic system reactivity in relation to tumor, and their presence may be of prognostic value. To test this hypothesis, 45 patients with laryngeal carcinoma were examined for the evidence of node reactivity. The classification applied by Tsakraklides et al. was used, defining patterns of lymphocyte predominance, germinal center appearance (indicating lymph node stimulation) and whether or not lymphocyte depletion had occurred. The presence of node reactivity was compared with long-term (5-year) survivals in the group of patients studied. By applying statistical analysis it was found that lymph node stimulation was a favorable prognostic factor, while its absence worsened prognosis.
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References
Bennett SH, Futrell JW, Roth JA, Hoye RC, Ketcham AS (1971) Prognostic significance of histologic host response in cancer of the larynx or hypopharynx. Cancer 28: 1255–1265
Berlinger NT, Tsakraklides V, Pollak K, Adams GL, Yang M, Good RA (1976) Prognostic significance of lymph node histology in patients with squamous cell carcinoma of the larynx, pharynx or oral cavity. Laryngoscope 86: 792–803
Black MM, Speer FD (1960) Lymph node reactivity in cancer patients. Surg Gynecol Obstet 110: 477–487
Carr I (1980) The pathologist's role in interpreting metastatic lymph node disease. In: Weiss L, Gilbert HA, Ballon SC (eds) Lymphatic system metastasis. Hall, Boston, p 138
Ferlito A, Polidoro F (1979) Biological and prognostic implications of the morphologic aspects of immune reaction in lymph nodes draining head neck cancers. J Laryngol Otol 93: 153–175
Hassman-Poznańska E, Musiatowicz B, Chodynicki S, Łazarczyk B (1984) Prognostic significance of the morphological findings of cervical lymph nodes in clinical course of laryngeal carcinoma. (in Polish). Otolaryngol Pol 38[Suppl]: 111–113
Hervy T, Jordan J, Kuczkowski J, Kowalska B (1989) Clinical and histological investigations of cervical lymph nodes in patients with laryngeal carcinoma. (in Polish). Otolaryngol Pok 43[Suppl]: 423–427
Madej M (1981) Lymph node reactions in laryngeal carcinoma. (in Polish). Ann Acad Med Stet 27: 253–266
Malicka K (1970) The assessment of defense function of lymph nodes on the basis of microscopical and clinical studies in laryngeal carcinoma. (in Polish). BTN Pr Wydz Nauk Przyr A14: 5–29
Sala O, Ferlito A (1976) Morphological observations of immunobiology of laryngeal cancer. Acta Otolaryngol (Stockh) 81: 353–363
Tsakraklides V, Anastassiades OT, Kersey JH (1973) Prognostic significance of regional lymph node histology in uterine cervical cancer. Cancer 31: 860–868
Zoller M, Goodman ML, Cummings CW (1978) Guidelines for prognosis in head and neck cancer with nodal metastasis. Laryngoscope 88: 135–140
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Stankiewicz, C. Prognostic significance of lymph node reactivity in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 251, 418–422 (1994). https://doi.org/10.1007/BF00181968
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DOI: https://doi.org/10.1007/BF00181968